Homology modeling and docking analyses of M. leprae Mur ligases reveals the common binding residues for structure based drug designing to eradicate leprosy

Journal of Molecular Modeling

Volumn 18, Issue 6, 2012, Pages 2659-2672

  Shanmugam, Anusuya ^a   Natarajan, Jeyakumar ^b  

^a Vinayaka Missions University   (India)

^b BHARATHIAR UNIVERSITY   (India)

Author keywords

Docking; Homology modeling; Multi drug therapy; Multi target inhibitor; Mur ligase; Peptidoglycan

Indexed keywords

BACTERIAL ENZYME; LIGASE; MURC LIGASE; MURD LIGASE; MURE LIGASE; MURF LIGASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; CATALYSIS; ENZYME BINDING; ENZYME STRUCTURE; MOLECULAR DOCKING; MYCOBACTERIUM LEPRAE; PRIORITY JOURNAL; STRUCTURAL HOMOLOGY;

ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CONSERVED SEQUENCE; DRUG DESIGN; GLUTAMIC ACID; GLYCINE; HISTIDINE; HUMANS; HYDROGEN BONDING; LEPROSY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM LEPRAE; PEPTIDE SYNTHASES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; STRUCTURAL HOMOLOGY, PROTEIN; THERMODYNAMICS;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM LEPRAE;

EID: 84864663415     PISSN: 16102940     EISSN: 09485023     Source Type: Journal    
DOI: 10.1007/s00894-011-1285-z     Document Type: Article

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