High-fat diets impair spatial learning of mice in the Y-maze paradigm: Ameliorative potential of α-lipoic acid

Journal of Medicinal Food

Volumn 15, Issue 8, 2012, Pages 713-717

  Cui, Yonghua ^a,b   Shu, Yuxin ^b   Zhu, Yuanyuan ^b   Shi, Yonghui ^a   Le, Guowei ^a  

^a JIANGNAN UNIVERSITY   (China)

^b MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

Author keywords

a lipoic acid; high fat diets; hippocampus; oxidative stress; Y maze

Indexed keywords

CATALASE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; THIOCTIC ACID;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FOOD INTAKE; HIPPOCAMPUS; IMPAIRED SPATIAL LEARNING; LEARNING DISORDER; LIPID DIET; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RECOGNITION;

ANIMALS; ANTIOXIDANTS; DIET, HIGH-FAT; DIETARY FATS; HIPPOCAMPUS; HUMANS; MALE; MAZE LEARNING; MEMORY; MICE; OXIDATIVE STRESS; THIOCTIC ACID;

ANIMALIA; MUS;

EID: 84864634038     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2011.1970     Document Type: Article

References (30)

1. Wilson RS, Bennett DA: Cognitive activity and risk of Alzheimer's disease. Psychol Sci 2003;12:87-91.
2. Greenwood CE, Winocur G: Cognitive impairment in rats fed high-fat diets: A specific effect of saturated fatty-acid intake. Behav Neurosci 1996;110:451-459.
3. Greenwood CE, Winocur G: High-fat diets, insulin resistance and declining cognitive function. Neurobiol Aging 2005;26:42-45.
4. Greenwood CE, Winocur G: Learning and memory impairment in rats fed a high saturated fat diet. Behav Neural Biol 1990;53: 74-87.
5. Winocur G, Greenwood CE: The effects of high fat diets and environmental influences on cognitive performance in rats. Behav Brain Res 1999;101:153-161.
6. Luchsinger JA, Tang MX, Shea S, Mayeux R: Caloric intake and the risk of Alzheimer disease. Arch Neurol 2002;59:1258-1263.
7. Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N: Dietary fats and the risk of incident Alzheimer disease. Arch Neurol 2003;60:194-200.
8. Kalmijn S, Feskens EJ, Launer LJ, Kromhout D: Polyunsaturated fatty acids, antioxidants, and cognitive function in very old men. Am J Epidemiol 1997;14:533-541.
9. Morris MC, Evans DA, Bienias JL, Tangney CC, Wilson RS: Dietary fat intake and 6-year cognitive change in an older biracial community population. Neurology 2004;62:1573-1579.
10. Pistell PJ, Morrison CD, Gupta S, et al.: Cognitive impairment following high fat diet consumption is associated with brain inflammation. J Neuroimmunol 2010;219:25-32.
11. Valladolid-Acebes I, Stucchi P, Cano V, et al.: High-fat diets impair spatial learning in the radial-arm maze in mice. Neurobiol Learn Mem 2011;95:80-85.
12. Winocur G, Greenwood CE: Studies of the effects of high fat diets on cognitive function in a rat model. Neurobiol Aging 2005;26:46-49.
13. Howland JG, Wang YT: Synaptic plasticity in learning and memory: Stress effects in the hippocampus. Prog Brain Res 2008;169:145-158.
14. Kanoski SE, Meisel RL, Mullins AJ, Davidson TL: The effects of energy rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. Behav Brain Res 2007;182:57-66.
15. Morrison CD, Pistell PJ, Ingram DK, et al.: High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: Implications for decreased Nrf2 signaling. J Neurochem 2010;114:1581-1589.
16. Farr SA, Yamada KA, Butterfield DA, Abdul HM, Xu L, Miller NE: Obesity and hypertriglyceridemia produce cognitive impairment. Endocrinology 2008;149:2628-2636.
17. Khawaja X, Xu J, Liang JJ, Barrett JE: Proteomic analysis of protein changes developing in rat hippocampus after chronic antidepressant treatment: Implications for depressive disorders and future therapies. J Neurosci Res 2004;75:451-460.
18. Lindqvist A, Mohapel P, Bouter B, Frielingsdorf H, Pizzo D, Brundin P: High-fat diet impairs hippocampal neurogenesis in male rats. Eur J Neurol 2006;13:1385-1388.
19. Xiao Y, Cui J, Shi Y, Le GW: Lipoic acid increases the expression of genes involved in bone formation in mice fed a highfat diet. Nutr Res 2011;31:309-317.
20. Yang RL, Li W, Shi YH, Le GW: Lipoic acid prevents high-fat diet-induced dyslipidemia and oxidative stress: A microarray analysis. Nutrition 2008;24:582-588.
21. Yang RL, Le GW, Li A, Zheng J, Shi Y: Effect of antioxidant capacity on blood lipid metabolism and lipoprotein lipase activity of rats fed a high-fat diet. Nutrition 2006;22:1185-1191.
22. Suzuki YJ, Tsuchiya M, Packer L: Lipoate prevents glucoseinduced protein modifications. Free Radic Res Commun 1992;17: 211-217.
23. Cui J, Xiao Y, Shi Y, Le GW, Miao X: Comparative proteome analysis of splenic lymphocytes in long-term high-fat diet and dietary supplement with lipoic acid mice. Cell Immunol 2010; 264:156-162.
24. Wu C, Zhu L, Yang Y, et al.: Effects of lipoic acid on oxidative stress blood glucose and blood lipid of mice fed with high-fat diet. Acta Nutr Sin 2010;3:489-494.
25. Dellu F, Contarino A, Simon H, et al.: Genetic differences in response to novelty and spatial memory using a two-trial recognition task in mice. Neurobiol Learn Mem 2000;73:31-48.
26. Akwa Y, Ladurelle N, Covey DF, Baulieu EE: The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: Distinct mechanisms? Proc Natl Acad Sci USA 2001; 98:14033-14037.
27. Hu R, Gong X, Duan Y, et al.: Neurotoxicological effects and the impairment of spatial recognition memory in mice. Biomaterials 2010;31:8043-8050.
28. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193: 265-275.
29. Stranahan AM, Norman ED, Lee K, et al.: Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus 2008;18:1085-1088.
30. Davies KJ: Oxidative stress: The paradox of aerobic life. Biochem Soc Symp 1995;61:1-31.