Management of cardiovascular disease risk factors in individuals with chronic spinal cord injury: An evidence-based review

Journal of Neurotrauma

Volumn 29, Issue 11, 2012, Pages 1999-2012

  Cragg, Jacquelyn J ^a   Stone, James A ^b   Krassioukov, Andrei V ^a,c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c GF STRONG REHABILITATION CENTRE   (Canada)

Author keywords

cardiovascular disease; clinical review; management; risk factors; spinal cord injury

Indexed keywords

ANTIHYPERTENSIVE AGENT; CAPTOPRIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NIFEDIPINE; PRAZOSIN; TRIACYLGLYCEROL;

AMERICAN SPINAL INJURY ASSOCIATION IMPAIRMENT SCALE; ANTIHYPERTENSIVE THERAPY; AUTONOMIC DYSREFLEXIA; BICYCLE ERGOMETRY; BLOOD PRESSURE FLUCTUATION; BRAIN HEMORRHAGE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CHRONIC DISEASE; CHRONIC INFLAMMATION; CLINICAL PRACTICE; DEATH; DYSLIPIDEMIA; ELECTROSTIMULATION; EVIDENCE BASED PRACTICE; GLYCEMIC CONTROL; HEALTH CARE PERSONNEL; HEALTH CARE QUALITY; HEART INFARCTION; HIGH RISK PATIENT; HIGH RISK POPULATION; HUMAN; HYPERTENSION; HYPERTENSIVE CRISIS; IMMOBILIZATION; LOW DRUG DOSE; ORTHOSIS; ORTHOSTATIC HYPOTENSION; PRIMARY PREVENTION; RANDOMIZED CONTROLLED TRIAL (TOPIC); RATING SCALE; RESISTANCE TRAINING; REVIEW; SPINAL CORD INJURY; TRAFFIC ACCIDENT; TREADMILL EXERCISE; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL;

CARDIOVASCULAR DISEASES; CHRONIC DISEASE; EVIDENCE-BASED MEDICINE; HUMANS; PRACTICE GUIDELINES AS TOPIC; RISK FACTORS; SPINAL CORD INJURIES;

EID: 84864622971     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2012.2313     Document Type: Review

References (113)

1. ADAPTE Collaboration. http://www.adapte.org/www/rubrique/ guideline-adaptation.php Alan, N., Ramer, L.M., Inskip, J.A., Golbidi, S., Ramer, M.S., Laher, I. Krassioukov, A.V. (2010). Recurrent autonomic dysreflexia exacerbates vascular dysfunction after spinal cord injury. Spine J. 10, 1108-1117.
2. Anson, C.A. Shepherd, C. (1996). Incidence of secondary complications in spinal cord injury. Int. J. Rehabil. Res. 19, 55-66.
3. Bauman, W.A. Spungen, A.M. (2008). Coronary heart disease in individuals with spinal cord injury: Assessment of risk factors. Spinal Cord 46, 466-476.
4. Bauman, W.A. Spungen, A.M. (1994). Disorders of carbohydrate and lipid metabolism in veterans with paraplegia or quadriplegia: A model of premature aging. Metabolism 43, 749-756.
5. Bauman, W.A., Spungen, A.M., Adkins, R.H. Kemp, B.J. (1999). Metabolic and endocrine changes in persons aging with spinal cord injury. Assist. Technol. 11, 88-96.
6. Bauman, W.A., Spungen, A.M., Zhong, Y.G., Rothstein, J.L., Petry, C. Gordon, S.K. (1992). Depressed serum high density lipoprotein cholesterol levels in veterans with spinal cord injury. Paraplegia 30, 697-703.
7. Brenes, G., Dearwater, S., Shapera, R., LaPorte, R.E. Collins, E. (1986). High density lipoprotein cholesterol concentrations in physically active and sedentary spinal cord injured patients. Arch. Phys. Med. Rehabil. 67, 445-450.
8. Cariga, P., Ahmed, S., Mathias, C.J. Gardner, B.P. (2002). The prevalence and association of neck (coat-hanger) pain and orthostatic (postural) hypotension in human spinal cord injury. Spinal Cord 40, 77-82.
9. CDA 2008 Clinical Practice Guidelines (2008). Definition, Classification and Diagnosis of Diabetes and Other Dysglycemic Categories. Can. J. Diabetes 32, (Suppl. 1) S10-S13.
10. Chelvarajah, R., Knight, S.L., Craggs, M.D. Middleton, F.R. (2009). Orthostatic hypotension following spinal cord injury: impact on the use of standing apparatus. NeuroRehabilitation 24, 237-242.
11. Chilibeck, P.D., Bell, G., Jeon, J., Weiss, C.B., Murdoch, G., MacLean, I., Ryan, E. Burnham, R. (1999). Functional electrical stimulation exercise increases GLUT-1 and GLUT-4 in paralyzed skeletal muscle. Metabolism 48, 1409-1413.
12. Cholesterol Treatment Trialists' (CTT) Collaboration, Baigent, C., Blackwell, L., Emberson, J., Holland, L.E., Reith, C., Bhala, N., Peto, R., Barnes, E.H., Keech, A., Simes, J. Collins, R. (2010). Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 376, 1670-681.
13. Claydon, V.E., Steeves, J.D. Krassioukov, A. (2006). Orthostatic hypotension following spinal cord injury: understanding clinical pathophysiology. Spinal Cord 44, 341-351.
14. Consortium for Spinal Cord Medicine. (2001). Acute Management of Autonomic Dysreflexia: Individuals with Spinal Cord Injury Presenting to Health-Care Facilities. Clinical Practice Guidelines. Paralyzed Veterans of America: Washington, DC
15. Cowan, R.E. Nash, M.S. (2010). Cardiovascular disease, SCI and exercise: unique risks and focused countermeasures. Disabil. Rehabil. 32, 2228-2236.
16. Cragg, J. Krassioukov, A. (2012). Autonomic dysreflexia. CMAJ 184, 66.
17. Curt, A., Nitsche, B., Rodic, B., Schurch, B. Dietz, V. (1997). Assessment of autonomic dysreflexia in patients with spinal cord injury. J. Neurol. Neurosurg. Psychiatry. 62, 473-477.
18. D'Agostino, R.B., Vasan, R.S., Pencina, M.J., Wolf, P.A., Cobain, M., Massaro, J.M. Kannel, W.B. (2008). General cardiovascular risk profile for use in primary care: The Framingham Heart Study. Circulation 117, 743-753.
19. Davies, A.L., Hayes, K.C. Dekaban, G.A. (2007). Clinical correlates of elevated serum concentrations of cytokines and autoantibodies in patients with spinal cord injury. Arch. Phys. Med. Rehabil. 88, 1384-1393.
20. De Backer, G., Ambrosioni, E., Borch-Johnsen, K., Brotons, C., Cifkova, R., Dallongeville, J., Ebrahim, S., Faergeman, O., Graham, I., Mancia, G., Manger Cats, V., Orth-Gomer, K., Perk, J., Pyorala, K., Rodicio, J.L., Sans, S., Sansoy, V., Sechtem, U., Silber, S., Thomsen, T., Wood, D. Third Joint Task Force of European and Other Societies on Cardiovascular Disease Prevention in Clinical Practice. 2003). European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force of European and Other Societies on Cardiovascular Disease Prevention in Clinical Practice. Eur. Heart J. 24, 1601-1610.
21. De Groot, P.C., Hjeltnes, N., Heijboer, A.C., Stal, W. Birkeland, K. (2003). Effect of training intensity on physical capacity, lipid profile and insulin sensitivity in early rehabilitation of spinal cord injured individuals. Spinal Cord 41, 673-679.
22. DeVivo, M.J., Krause, J.S. Lammertse, D.P. (1999). Recent trends in mortality and causes of death among persons with spinal cord injury. Arch. Phys. Med. Rehabil. 80, 1411-1419.
23. Dolinak, D. Balraj, E. (2007). Autonomic dysreflexia and sudden death in people with traumatic spinal cord injury. Am. J. Forensic Med. Pathol. 28, 95-98.
24. Downs, S.H. Black, N. (1998). The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J. Epidemiol. Community Health 52, 377-384.
25. Ekland, M.B., Krassioukov, A.V., McBride, K.E. Elliott, S.L. (2008). Incidence of autonomic dysreflexia and silent autonomic dysreflexia in men with spinal cord injury undergoing sperm retrieval: implications for clinical practice. J. Spinal Cord Med. 31, 33-39.
26. Elliott, S. Krassioukov, A. (2006). Malignant autonomic dysreflexia in spinal cord injured men. Spinal Cord 44, 386-392.
27. El-Sayed, M.S. Younesian, A. (2005). Lipid profiles are influenced by arm cranking exercise and training in individuals with spinal cord injury. Spinal Cord 43, 299-305.
28. Eltorai, I., Kim, R., Vulpe, M., Kasravi, H. Ho, W. (1992). Fatal cerebral hemorrhage due to autonomic dysreflexia in a tetraplegic patient: Case report and review. Paraplegia 30, 355-360.
29. ESC/EAS Guidelines for the management of dyslipidaemias. (2011). Atherosclerosis 217 (Suppl. 1), 1-44.
30. Executive Summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation.treatment of high cholesterol in adults Adult treatment panel III 2001 JAMA 285 2486-2497.
31. Faghri, P.D. Yount, J. (2002). Electrically induced and voluntary activation of physiologic muscle pump: A comparison between spinal cord-injured and able-bodied individuals. Clin. Rehabil. 16, 878-885.
32. Fervers, B., Burgers, J.S., Voellinger, R., Brouwers, M., Browman, G.P., Graham, I.D., Harrison, M.B., Latreille, J., Mlika-Cabane, N., Paquet, L., Zitzelsberger, L., Burnand, B. ADAPTE Collaboration. (2011). Guideline adaptation: An approach to enhance efficiency in guideline development and improve utilisation. BMJ Qual. Saf. 20, 228-236.
33. Foley, N.C., Bhogal, S.K., Teasell, R.W., Bureau, Y. Speechley, M.R. (2006). Estimates of quality and reliability with the physiotherapy evidence-based atabase scale to assess the methodology of randomized controlled trials of pharmacological and nonpharmacological interventions. Phys. Ther. 86, 817-824.
34. Frisbie, J.H. Steele, D.J. (1997). Postural hypotension and abnormalities of salt and water metabolism in myelopathy patients. Spinal Cord 35, 303-307.
35. Frost, F., Roach, M.J., Kushner, I. Schreiber, P. (2005). Inflammatory C-reactive protein and cytokine levels in asymptomatic people with chronic spinal cord injury. Arch. Phys. Med. Rehabil. 86, 312-317.
36. Garshick, E., Kelley, A., Cohen, S.A., Garrison, A., Tun, C.G., Gagnon, D Brown, R. (2005). A prospective assessment of mortality in chronic spinal cord injury. Spinal Cord 43, 408-416.
37. Genest, J., McPherson, R., Frohlich, J., Anderson, T., Campbell, N., Carpentier, A., Couture, P., Dufour, R., Fodor, G., Francis, G.A., Grover, S., Gupta, M., Hegele, R.A., Lau, D.C., Leiter, L., Lewis, G.F., Lonn, E., Mancini, G.B., Ng, D., Pearson, G.J., Sniderman, A., Stone, J.A. (2009). 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult-2009 recommendations. Can. J. Cardiol. 25, 567-579.
38. Gibson, A.E., Buchholz, A.C., Martin Ginis, K.A. SHAPESCI Research Group. (2008). C-Reactive protein in adults with chronic spinal cord injury: increased chronic inflammation in tetraplegia vs. paraplegia. Spinal Cord 46, 616-621.
39. Ginis, K.A., Hicks, A.L., Latimer, A.E., Warburton, D.E., Bourne, C., Ditor, D.S., Goodwin, D.L., Hayes, K.C., McCartney, N., McIlraith, A., Pomerleau, P., Smith, K., Stone, J.A. Wolfe, D.L. (2011). The development of evidence-informed physical activity guidelines for adults with spinal cord injury. Spinal Cord 49, 1088-1096.
40. Groah, S.L., Nash, M.S., Ward, E.A., Libin, A., Mendez, A.J., Burns, P., Elrod, M. Hamm, L.F. (2011). Cardiometabolic risk in community-dwelling persons with chronic spinal cord injury. J Cardiopulm. Rehabil. Prev. 31, 73-80.
41. Heldenberg, D., Rubinstein, A., Levtov, O., Werbin, B. Tamir, I. (1981). Serum lipids and lipoprotein concentrations in young quadriplegic patients. Atherosclerosis 39, 163-167.
42. Hjeltnes, N., Galuska, D., Bjornholm, M., Aksnes, A.K., Lannem, A., Zierath, J.R. Wallberg-Henriksson, H. (1998). Exerciseinduced overexpression of key regulatory proteins involved in glucose uptake and metabolism in tetraplegic persons: molecular mechanism for improved glucose homeostasis. FASEB J. 12, 1701-1712.
43. Ho, C.P. Krassioukov, A.V. (2010). Autonomic dysreflexia and myocardial ischemia. Spinal Cord 48, 714-715.
44. Hollis, B., Lafavor, J., Mauder, V., Mokshagundam, S. Olive, J. (2009). Inflammation and insulin sensitivity in spinal cord injured subjects. Med. Sci. Sports Exerc. 41, 73.
45. Hooker, S.P. Wells, C.L. (1989). Effects of low- and moderate- intensity training in spinal cord-injured persons. Med. Sci. Sports Exerc. 21, 18-22.
46. Hopman, M.T., Groothuis, J.T., Flendrie, M., Gerrits, K.H. Houtman, S. (2002). Increased vascular resistance in paralyzed legs after spinal cord injury is reversible by training. J. Appl. Physiol. 93, 1966-1972.
47. Houtman, S., Colier, W.N., Oeseburg, B. Hopman, M.T. (2000). Systemic circulation and cerebral oxygenation during head-up tilt in spinal cord injured individuals. Spinal Cord 38, 158-163.
48. Imai, K., Kadowaki, T. Aizawa, Y. (2004). Standardized indices of mortality among persons with spinal cord injury: Accelerated aging process. Ind. Health 42, 213-218.
49. Jeon, J.Y., Weiss, C.B., Steadward, R.D., Ryan, E., Burnham, R.S., Bell, G., Chilibeck, P. Wheeler, G.D. (2002). Improved glucose tolerance and insulin sensitivity after electrical stimulation- assisted cycling in people with spinal cord injury. Spinal Cord 40, 110-117.
50. Karlsson, A.K., Attvall, S., Jansson, P.A., Sullivan, L. Lonnroth, P. (1995). Influence of the sympathetic nervous system on insulin sensitivity and adipose tissue metabolism: A study in spinal cord-injured subjects. Metabolism 44, 52-58.
51. Karlsson, A.K. (1999). Autonomic dysreflexia. Spinal Cord 37, 383-391.
52. Kirshblum, S.C., House, J.G. O'Connor, K.C. (2002). Silent autonomic dysreflexia during a routine bowel program in persons with traumatic spinal cord injury: A preliminary study. Arch. Phys. Med. Rehabil. 83, 1774-1776.
53. Krassioukov, A., Eng, J.J.,Warburton, D.E., Teasell, R. Spinal Cord Injury Rehabilitation Evidence Research Team. (2009a). A systematic review of the management of orthostatic hypotension after spinal cord injury. Arch. Phys. Med. Rehabil. 90, 876-885.
54. Krassioukov, A.,Warburton, D.E., Teasell, R., Eng, J.J. Spinal Cord Injury Rehabilitation Evidence Research Team. (2009b). A systematic review of the management of autonomic dysreflexia after spinal cord injury. Arch. Phys. Med. Rehabil. 90, 682-695.
55. Krum, H., Howes, L.G., Brown, D.J., Ungar, G., Moore, P., McNeil, J.J. Louis, W.J. (1992). Risk factors for cardiovascular disease in chronic spinal cord injury patients. Paraplegia 30, 381-388.
56. Lee, M.Y., Myers, J., Hayes, A., Madan, S., Froelicher, V.F., Perkash, I. Kiratli, B.J. (2005). C-reactive protein, metabolic syndrome. insulin resistance in individuals with spinal cord injury. J. Spinal Cord Med. 28, 20-25.
57. Liang, H., Mojtahedi, M.C., Chen, D. Braunschweig, C.L. (2008). Elevated C-reactive protein associated with decreased high-density lipoprotein cholesterol in men with spinal cord injury. Arch. Phys. Med. Rehabil. 89, 36-41.
58. Lieberman, J.A., Hammond, F.M., Barringer, T.A., Goff, D.C. Jr., Norton, H.J., Bockenek, W.L. Scelza, W.M. (2011a). Adherence with the National Cholesterol Education Program guidelines in men with chronic spinal cord injury. J. Spinal Cord Med. 34, 28-34.
59. Lieberman, J.A., Hammond, F.M., Barringer, T.A., Norton, H.J., Goff, D.C. Jr., Bockenek, W.L. Scelza, W.M. (2011b). Comparison of coronary artery calcification scores and National Cholesterol Education program guidelines for coronary heart disease risk assessment and treatment paradigms in individuals with chronic traumatic spinal cord injury. J. Spinal Cord Med. 34, 233-240.
60. Lindan, R., Joiner, E., Freehafer, A.A. Hazel, C. (1980). Incidence and clinical features of autonomic dysreflexia in patients with spinal cord injury. Paraplegia 18, 285-292.
61. Mackay, J. Mensah, G. (eds.) (2004). The Atlas of Heart Disease and Stroke. World Health Organization: Geneva. Mahoney, E.T., Bickel, C.S., Elder, C., Black, C., Slade, J.M., Apple, D. Jr. Dudley, G.A. (2005). Changes in skeletal muscle size and glucose tolerance with electrically stimulated resistance training in subjects with chronic spinal cord injury. Arch. Phys. Med. Rehabil. 86, 1502-1504.
62. Mathias, C.J. Frankel, H.L. (1983). Clinical manifestations of malfunctioning sympathetic mechanisms in tetraplegia. J. Auton. Nerv. Syst. 7, 303-312.
63. Mathias, C.J. (1995). Orthostatic hypotension: Causes, mechanisms. influencing factors. Neurology 45, S6-S11.
64. Middleton, J.W., Leong, G. Mann, L. (2008a). Management of spinal cord injury in general practice-part 1. Aust. Fam. Physician 37, 229-233.
65. Middleton, J.W., Leong, G. Mann, L. (2008b). Management of spinal cord injury in general practice-part 2. Aust. Fam. Physician 37, 331-332, 335-338.
66. Mohr, T., Dela, F., Handberg, A., Biering-Sorensen, F., Galbo, H. Kjaer, M. (2001). Insulin action and long-term electrically induced training in individuals with spinal cord injuries. Med. Sci. Sports Exerc. 33, 1247-1252.
67. Moseley, A.M., Herbert, R.D., Sherrington, C. Maher, C.G. (2002). Evidence for physiotherapy practice: A survey of the Physiotherapy Evidence Database (PEDro). Aust. J. Physiother. 48, 43-49.
68. Mukand, J., Karlin, L., Barrs, K. Lublin, P. (2001). Midodrine for the management of orthostatic hypotension in patients with spinal cord injury: A case report. Arch. Phys. Med. Rehabil. 82, 694-696.
69. Munakata, M., Kameyama, J., Kanazawa, M., Nunokawa, T., Moriai, N. Yoshinaga, K. (1997). Circadian blood pressure rhythm in patients with higher and lower spinal cord injury: Simultaneous evaluation of autonomic nervous activity and physical activity. J. Hypertens. 15, 1745-1749.
70. Myers, J., Lee, M. Kiratli, J. (2007). Cardiovascular disease in spinal cord injury: An overview of prevalence, risk, evaluation. management. Am. J. Phys. Med. Rehabil. 86, 142-152.
71. Nash, M.S. (2005). Exercise as a health-promoting activity following spinal cord injury. J. Neurol. Phys. Ther. 29, 87-103, 106.
72. Nash, M.S., Jacobs, P.L., Mendez, A.J. Goldberg, R.B. (2001 Circuit resistance training improves the atherogenic lipid profiles of persons with chronic paraplegia. J. Spinal Cord Med. 24, 2-9.
73. Nash, M.S., Lewis, J.E., Dyson-Hudson, T.A., Szlachcic, Y., Yee, F., Mendez, A.J., Spungen, A.M. Bauman, W.A. (2011). Safety, tolerance. efficacy of extended-release niacin monotherapy for treating dyslipidemia risks in persons with chronic tetraplegia: A randomized multicenter controlled trial. Arch. Phys. Med. Rehabil. 92, 399-410.
74. Nieshoff, E.C., Birk, T.J., Birk, C.A., Hinderer, S.R. Yavuzer, G. (2004). Double-blinded, placebo-controlled trial of midodrine for exercise performance enhancement in tetraplegia: A pilot study. J. Spinal Cord Med. 27, 219-225.
75. Ozgurtas, T., Alaca, R., Gulec, M. Kutluay, T. (2003). Do spinal cord injuries adversely affect serum lipoprotein profiles? Mil. Med. 168, 545-547.
76. Pan, S.L., Wang, Y.H., Lin, H.L., Chang, C.W., Wu, T.Y. Hsieh, E.T. (2005). Intracerebral hemorrhage secondary to autonomic dysreflexia in a young person with incomplete C8 tetraplegia: A case report. Arch. Phys. Med. Rehabil. 86, 591-593.
77. Phillips, S.M., Stewart, B.G., Mahoney, D.J., Hicks, A.L., McCartney, N., Tang, J.E., Wilkinson, S.B., Armstrong, D. Tarnopolsky, M.A. (2004). Body-weight-support treadmill training improves blood glucose regulation in persons with incomplete spinal cord injury. J. Appl. Physiol. 97, 716-724.
78. Pine, Z.M., Miller, S.D. Alonso, J.A. (1991). Atrial fibrillation associated with autonomic dysreflexia. Am. J. Phys. Med. Rehabil. 70, 271-273.
79. Raymond, J., Davis, G.M. van der Plas, M. (2002). Cardiovascular responses during submaximal electrical stimulationinduced leg cycling in individuals with paraplegia. Clin. Physiol. Funct. Imaging 22, 92-98.
80. Ridker, P.M., Danielson, E., Fonseca, F.A., Genest, J., Gotto, A.M. Jr., Kastelein, J.J., Koenig, W., Libby, P., Lorenzatti, A.J., MacFadyen, J.G., Nordestgaard, B.G., Shepherd, J., Willerson, J.T., Glynn, R.J. JUPITER Study Group. (2008). Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N. Engl. J. Med. 359, 2195-2207.
81. Ridker, P.M., Hennekens, C.H., Buring, J.E. Rifai, N. (2000). C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N. Engl. J. Med. 342, 836-843.
82. Ridker, P.M., Rifai, N., Pfeffer, M.A., Sacks, F. Braunwald, E. (1999). Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators. Circulation 100, 230-235.
83. Ridker, P.M., Wilson, P.W. Grundy, S.M. (2004). Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk? irculation 109, 2818-2825.
84. Rindfleisch, J.A. Muller, D. (2005). Diagnosis and management of rheumatoid arthritis. Am. Fam. Physician 72, 1037-1047.
85. Ross, R. (1999). Atherosclerosis is an inflammatory disease. Am. Heart J. 138, S419-S420.
86. Sackett, D.L., Strauss, S.E., Richardson, W.S., Rosenberg, W. Haynes, R.B. (2000). Evidence-Based Medicine: How to Practice and Teach EBM. Churchill Livingstone: Edinburgh
87. Schmid, A., Halle, M., Stutzle, C., Konig, D., Baumstark, M.W., Storch, M.J., Schmidt-Trucksass, A., Lehmann, M., Berg, A. Keul, J. (2000). Lipoproteins and free plasma catecholamines in spinal cord injured men with different injury levels. Clin. Physiol. 20, 304-310.
88. SCI Action Canada. www.sciactioncanada.ca/. SCIRE Team. (2006). SCIRE: Spinal Cord Injury Rehabilitation Evidence. http://www.scireproject.com/home. Shaughnessy, A.F., Slawson, D.C. Bennett, J.H. (1994). Becoming an information master: A guidebook to the medical information jungle. J. Fam. Pract. 39, 489-499.
89. Slawson, D.C. Shaughnessy, A.F. (2000). Becoming an information master: using POEMs to change practice with confidence. Patient-Oriented Evidence that Matters. J. Fam. Pract. 49, 63-67.
90. Slawson, D.C., Shaughnessy, A.F.Bennett, J.H. (1994). Becoming a medical information master: Feeling good about not knowing everything. J. Fam. Pract. 38, 505-513.
91. Solomonow, M., Reisin, E., Aguilar, E., Baratta, R.V., Best, R. D'Ambrosia, R. (1997). Reciprocating gait orthosis powered with electrical muscle stimulation (RGO II). Part II: Medical evaluation of 70 paraplegic patients. Orthopedics 20, 411-418.
92. Steins, S.A., Johnson, M.C. Lyman, P.J. (1995). Cardiac rehabilitation in patients with spinal cord injuries. Phys. Med. Rehabil. Clin. North Am. 6, 236-296.
93. Stewart, B.G., Tarnopolsky, M.A., Hicks, A.L., McCartney, N., Mahoney, D.J., Staron, R.S. Phillips, S.M. (2004). Treadmill training-induced adaptations in muscle phenotype in persons with incomplete spinal cord injury. Muscle Nerve 30, 61-68.
94. Stone, J.A. (2011). Framing cardiovascular disease event risk prediction. Can. J. Cardiol. 27, 171-173.
95. Teasell, R.W., Arnold, J.M., Krassioukov, A. Delaney, G.A. (2000). Cardiovascular consequences of loss of supraspinal control of the sympathetic nervous system after spinal cord injury. Arch. Phys. Med. Rehabil. 81, 506-516.
96. Ten Harkel, A.D., van Lieshout, J.J. Wieling, W. (1994). Effects of leg muscle pumping and tensing on orthostatic arterial pressure: A study in normal subjects and patients with autonomic failure. Clin. Sci. (Lond.) 87, 553-558.
97. The ConsensusCommittee of theAmerican Autonomic Society and the American Academy of Neurology. (1996). Consensus statement on the definition of orthostatic ypotension, pure autonomic failure. ultiple system atrophy. Neurology 146, 1470.
98. Valles, M., Benito, J., Portell, E. Vidal, J. (2005). Cerebral hemorrhage due to autonomic dysreflexia in a spinal cord injury patient. Spinal Cord 43, 738-740.
99. van den Berg, M.E., Castellote, J.M., Mahillo-Fernandez, I. de Pedro-Cuesta, J. (2010). Incidence of spinal cord injury worldwide: A systematic review. Neuroepidemiology 34, 184- 192; discussion 192.
100. Vaziri, N.D. (2003). Nitric oxide in microgravity-induced orthostatic intolerance: Relevance to spinal cord injury. J. Spinal Cord Med. 26, 5-11.
101. Verwoert, G.C., Mattace-Raso, F.U., Hofman, A., Heeringa, J., Stricker, B.H., Breteler, M.M. Witteman, J.C. (2008). Orthostatic hypotension and risk of cardiovascular disease in elderly people: The Rotterdam study. J. Am. Geriatr. Soc. 56, 1816-1820.
102. Wahman, K., Nash, M.S., Lewis, J.E., Seiger, A. Levi, R. (2011). Cardiovascular disease risk and the need for prevention after paraplegia determined by conventional multifactorial risk models: The Stockholm spinal cord injury study. J. Rehabil. Med. 43, 237-242.
103. Wallin, B.G. Stjernberg, L. (1984). Sympathetic activity in man after spinal cord injury. Outflow to skin below the lesion. Brain 107, 183-198.
104. Wang, T.D., Wang, Y.H., Huang, T.S., Su, T.C., Pan, S.L. Chen, S.Y. (2007). Circulating levels of markers of inflammation and endothelial activation are increased n men with chronic spinal cord injury. J. Formos. Med. Assoc. 106, 919-928.
105. Wecht, J.M., De Meersman, R.E., Weir, J.P., Spungen, A.M. Bauman, W.A. (2003). Cardiac autonomic responses to progressive head-up tilt in individuals with paraplegia. Clin. Auton. Res. 13, 433-438.
106. Wecht, J.M., Radulovic, M., Lafountaine, M.F., Rosado-Rivera, D., Zhang, R.L. Bauman, W.A. (2009). Orthostatic responses to nitric oxide synthase inhibition in persons with tetraplegia. Arch. Phys. Med. Rehabil. 90, 1428-1434.
107. West, C.R., Mills, P. Krassioukov, A.V. (2012). Influence of the neurological level of spinal cord injury on cardiovascular outcomes in humans: A meta-analysis. Spinal Cord 50, 484-492.
108. Whiteneck, G.G., Charlifue, S.W., Frankel, H.L., Fraser, M.H., Gardner, B.P., Gerhart, K.A., Krishnan, K.R., Menter, R.R., Nuseibeh, I. Short, D.J. (1992). Mortality, morbidity psychosocial outcomes of persons spinal cord injured more than 20 years ago. Paraplegia 30, 617-630.
109. Yarkony, G.M., Katz, R.T. Wu, Y.C. (1986). Seizures secondary to autonomic dysreflexia. Arch. Phys. Med. Rehabil. 67, 834-835.
110. Yekutiel, M., Brooks, M.E., Ohry, A., Yarom, J. Carel, R. (1989). The prevalence of hypertension, ischaemic heart disease and diabetes in traumatic spinal cord injured patients and amputees. Paraplegia 27, 58-62.
111. Yoo, K.Y., Jeong, C.W., Kim, W.M., Lee, H.K., Kim, S.J., Jeong, S.T., Lee, J.K. Lee, J. (2010). Fatal cerebral hemorrhage associated with autonomic hyperreflexia during surgery in the prone position in a quadriplegic patient: A case report. Minerva Anestesiol. 76, 554-558.
112. Yusuf, S., Hawken, S., Ounpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., Lisheng, L. INTERHEART Study Investigators. (2004). Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Casecontrol study. Lancet 364, 937-952.
113. Zlotolow, S.P., Levy, E. Bauman, W.A. (1992). The serum lipoprotein profile in veterans with paraplegia: The relationship to nutritional factors and body mass index. J. Am. Paraplegia Soc. 15, 158-162