The severity of brain damage determines bone marrow stromal cell therapy efficacy in a traumatic brain injury model

Journal of Trauma and Acute Care Surgery

Volumn 72, Issue 5, 2012, Pages 1203-1212

  Bonilla, Celia ^a   Zurita, Mercedes ^a   Otero, Laura ^a   Aguayo, Concepción ^a   Rico, Miguel A ^a   Vaquero, Jesús ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

Author keywords

Bone marrow stromal cells; Cell therapy; Traumatic brain injury

Indexed keywords

NESTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW STROMAL CELL TRANSPLANTATION; BONE MARROW TRANSPLANTATION; BRAIN DAMAGE; BRAIN FUNCTION; CELL ISOLATION; CONTROLLED STUDY; DISEASE SEVERITY; EXPERIMENTAL MODEL; FEMALE; FLOW CYTOMETRY; FOLLOW UP; IMMUNOHISTOCHEMISTRY; INJURY SEVERITY; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCORING SYSTEM; SEIZURE; STROMA CELL; THERAPY EFFECT; TRAUMATIC BRAIN INJURY;

ANIMALS; BONE MARROW TRANSPLANTATION; BRAIN; BRAIN INJURIES; DISEASE MODELS, ANIMAL; FEMALE; FOLLOW-UP STUDIES; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; STROMAL CELLS; TISSUE THERAPY; TRAUMA SEVERITY INDICES; TREATMENT OUTCOME;

EID: 84864544404     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e318248bdcf     Document Type: Article

References (47)

1. Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: A brief overview. J Head Trauma Rehabil. 2006;21:375-378.
2. Hawthorne G, Gruen RL, Kaye AH. Traumatic brain injury and longterm quality of life: Findings from an Australian study. J Neurotrauma. 2009;26:1623-1633.
3. Lu D, Li Y, Wang L, Chen J, Mahmood A, Chopp M. Intraarterial administration of marrow stromal cells in a rat model of traumatic brain injury. J Neurotrauma. 2001;18:813-819.
4. Lu D, Mahmood A, Wang L, Li Y, Lu M, Chopp M. Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome. Neuroreport. 2001;12:559-563.
5. Lu J, Moochhala S, Moore XL, et al. Adult bone marrow cells differentiate into neural phenotypes and improve functional recovery in rats following traumatic brain injury. Neurosci Lett. 2006;398:12-17.
6. Mahmood A, Lu D, Wang L, Li Y, Lu M, Chopp M. Treatment of traumatic brain injury in female rats with intravenous administration of bone marrow stromal cells. Neurosurgery. 2001;49:1196-1203; discussion 1203-1204.
7. Mahmood A, Lu D, Lu M, Chopp M. Treatment of traumatic brain injury in adult rats with intravenous administration of human bone marrow stromal cells. Neurosurgery. 2003;53:697-702.
8. Mahmood A, Lu D, Chopp M. Intravenous administration of marrow stromal cells (MSCs) increases the expression of growth factors in rat brain after traumatic brain injury. J Neurotrauma. 2004;21:33-39.
9. Mahmood A, Lu D, Qu C, Goussev A, Chopp M. Treatment of traumatic brain injury with a combination therapy of marrow stromal cells and atorvastatin in rats. Neurosurgery. 2007;60:546-553.
10. Bonilla C, Zurita M, Otero L, Aguayo C, Vaquero J. Delayed intralesional transplantation of bone marrow stromal cells increases endogenous neurogenesis and promotes functional recovery after severe traumatic brain injury. Brain Inj. 2009;23:760-769.
11. Allen AR. Surgery of experimental lesion of spinal cord equivalent to crush injury of fracture dislocation of spinal column. JAMA. 1911;57: 878-880.
12. Zurita M, Vaquero J. Bone marrow stromal cells can achieve cure of chronic paraplegic rats: Functional and morphological outcome one year after transplantation. Neurosci Lett. 2006;402:51-56.
13. Chen J, Sanberg PR, Li Y, et al. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke. 2001;32:2682-2688.
14. Otero L, Zurita M, Aguayo C, Bonilla C, Rodríguez A, Vaquero J. Video-Tracking-Box linked to Smart software as a tool for evaluation of motor activity and orientation in brain-injured rats. J Neurosci Methods. 2010;188:53-57.
15. Houchens DP. Therapy of Human Tumors in Athymic (Nude) Mice. Proceeding of the symposium on the use of athymic nude mice in cancer research. New York: Gustav Fischer; 1978:266-280.
16. Morales C, Zurita M, Vaquero J. Antitumoral effect of irinotecan (CPT-11) on an experimental model of maligna neuroectodermal tumor. J Neurooncol. 2002;56:219-226.
17. Tagliaferri F, Compagnone C, Korsic M, Servadei F, Kraus J. A systematic review of brain injury epidemiology in Europe. Acta Neurochir (Wien). 2006;148:255-268.
18. Thurman D, Guerrero J. Trends in hospitalization associated with traumatic brain injury. JAMA. 1999;282:954-957.
19. Beauchamp K, Mutlak H, Smith WR, Shohami E, Stahel PF. Pharmacology of traumatic brain injury: Where is the "golden bullet"? Mol Med. 2008;14:731-740.
20. Narayan RK, Michel ME, Ansell B, et al. Clinical trials in head injury. J Neurotrauma. 2002;19:503-557.
21. Royo NC, Shimizu S, Schouten JW, Stover JF, McIntosh TK. Pharmacology of traumatic brain injury. Curr Opin Pharmacol. 2003;3:27-32.
22. Morganti-Kossmann MC, Yan E, Bye N. Animal models of traumatic brain injury: is there an optimal model to reproduce human brain injury in the laboratory? Injury. 2010;41:S10-S13.
23. Schwarzbach E, Bonislawski DP, Xiong G, Cohen AS. Mechanisms underlying the inability to induce area CA1 LTP in the mouse after traumatic brain injury. Hippocampus. 2006;16:541-550.
24. Tsenter J, Beni-Adani L, Assaf Y, Alexandrovich AG, Trembovler V, Shohami E. Dynamic changes in the recovery after traumatic brain injury in mice: effect of injury severity on T2-weighted MRI abnormalities, and motor and cognitive functions. J Neurotrauma. 2008;25:324-333.
25. Schwarzbold ML, Rial D, De Bem T, et al. Effects of traumatic brain injury of different severities on emotional, cognitive, and oxidative stress-related parameters in mice. J Neurotrauma. 2010;27:1883-1893.
26. Jones NC, Cardamone L, Williams JP, Salzberg MR, Myers D, O'Brien TJ. Experimental traumatic brain injury induces a pervasive hyperanxious phenotype in rats. J Neurotrauma. 2008;25:1367-1374.
27. Pandey DK, Yadav SK, Mahesh R, Rajkumar R. Depression-like and anxiety-like behavioural aftermaths of impact accelerated traumatic brain injury in rats: a model of comorbid depression and anxiety? Behav Brain Res. 2009;205:436-442.
28. Cernak I. Animal models of head injury. NeuroRx. 2005;2:410-422.
29. Reilly PL. Brain injury: the pathophysiology of the first hours. "Talk and Die revisited." J Clin Neurosci. 2001;8:398-403.
30. DeKosky ST, Kochanek PM, Clark RS, Ciallella JR, Dixon CE. Secondary injury after head trauma: Subacute and long-term mechanisms. Semin Clin Neuropsychiatry. 1998;3:176-185.
31. Flierl MA, Stahel PF, Beauchamp KM, Morgan SJ, Smith WR, Shohami E. Mouse closed head injury model induced by a weight-drop device. Nat Protoc. 2009;4:1328-1337.
32. Mahmood A, Lu D, Wang L, Chopp M. Intracerebral transplantation of marrow stromal cells cultured with neurotrophic factors promotes functional recovery in adult rats subjected to traumatic brain injury. J Neurotrauma. 2002;19:1609-1617.
33. Qu C, Mahmood A, Lu D, Goussev A, Xiong Y, Chopp M. Treatment of traumatic brain injury in mice with marrow stromal cells. Brain Res. 2008;1208:234-239.
34. Fujimoto ST, Longhi L, Saatman KE, Conte V, Stocchetti N, McIntosh TK. Motor and cognitive function evaluation following experimental traumatic brain injury. Neurosci Biobehav Rev. 2004;28:365-378.
35. Chong ZZ, Li F, Maiese K. Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol. 2005;75:207-246.
36. Darwish RS, Amiridze N, Aarabi B. Nitrotyrosine as an oxidative stress marker: evidence for involvement in neurologic outcome in human traumatic brain injury. J Trauma. 2007;63:439-442.
37. Werner C, Engelhard K. Pathophysiology of traumatic brain injury. Br J Anaesth. 2007;99:4-9.
38. Xiong Y, Mahmood A, Chopp M. Emerging treatments for traumatic brain injury. Expert Opin Emerg Drugs. 2009;14:67-84.
39. Chen X, Katakowski M, Li Y, et al. Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: growth factor production. J Neurosci Res. 2002;69:687-691.
40. Chopp M, Li Y. Treatment of neural injury with marrow stromal cells. Lancet Neurol. 2002;1:92-100.
41. Yoshimura S, Teramoto T, Whalen MJ, et al. FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice. J Clin Invest. 2003;112:1202-1210.
42. Chen J, Chopp M. Neurorestorative treatment of stroke: cell and pharmacological approaches. NeuroRx. 2006;3:466-473.
43. Vaquero J, Zurita M. Bone marrow stromal cells for spinal cord repair: a challenge for contemporary neurobiology. Histol Histopathol. 2009; 24:107-116.
44. Vaquero J, Zurita M. Functional recovery after severe CNS trauma: current perspectives for cell therapy with bone marrow stromal cells. Prog Neurobiol. 2011;93:341-349.
45. Zurita M, Otero L, Aguayo C, et al. Cell therapy for spinal cord repair: optimization of biologic scaffolds for survival and neural differentiation of human bone marrow stromal cells. Cytotherapy. 2010;12:522-537.
46. Cox CS Jr, Baumgartner JE, Harting MT, et al. Autologous bone marrow mononuclear cell therapy for severe traumatic brain injury in children. Neurosurgery. 2011;68:588-600.
47. Zhang ZX, Guan LX, Zhang K, Zhang Q, Dai LJ. A combined procedure to deliver autologous mesenchymal stromal cells to patients with traumatic brain injury. Cytotherapy. 2008;10:134-139.