ADAM10 regulates transcription factor expression required for plasma cell function

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Chaimowitz, Natalia S ^a   Kang, Dae Joong ^a   Dean, Lee M ^a   Conrad, Daniel H ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM10 ENDOPEPTIDASE; IMMUNOGLOBULIN G1; MESSENGER RNA; PROTEIN BCL 6; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CELL COUNT; CELL FUNCTION; CELL ISOLATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME DEFICIENCY; EXTRAFOLLICULAR B CELL; GENE; GENE REARRANGEMENT; GENETIC RECOMBINATION; GERMINAL CENTER; IRF4 GENE; MOUSE; NONHUMAN; PLASMA CELL; PRDM1 GENE; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION REGULATION; XBP1 GENE;

ADAM PROTEINS; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIBODY FORMATION; BACTERIAL PROTEINS; CELL COUNT; CELL SEPARATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GERMINAL CENTER; IMMUNOGLOBULIN G; IMMUNOLOGIC MEMORY; INTEGRASES; LUMINESCENT PROTEINS; MEMBRANE PROTEINS; MICE; PLASMA CELLS; TRANSCRIPTION FACTORS;

MUS;

EID: 84864534874     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042694     Document Type: Article

References (45)

1. Smith KGC, Hewitson TD, Nossal GJV, Tarlinton DM, (1996) The phenotype and fate of the antibody-forming cells of the splenic foci. Eur J Immunol 26: 444-448.
2. Erickson LD, Durell BG, Vogel LA, O'Connor BP, Cascalho M, et al. (2002) Short-circuiting long-lived humoral immunity by the heightened engagement of CD40. J Clin Invest 109: 613-620.
3. Cozine CL, Wolniak KL, Waldschmidt TJ, (2005) The primary germinal center response in mice. Curr Opin Immunol 17: 298-302 doi:10.1016/j.coi.2005.04.007.
4. Shapiro-Shelef M, Lin K-I, McHeyzer-Williams LJ, Liao J, McHeyzer-Williams MG, et al. (2003) Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 19: 607-620.
5. Shaffer AL, Lin K-I, Kuo TC, Yu X, Hurt EM, et al. (2002) Blimp-1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program. Immunity 17: 51-62.
6. Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, et al. (2001) Plasma cell differentiation requires the transcription factor XBP-1. Nature 412: 300-307 doi:10.1038/35085509.
7. Klein U, Casola S, Cattoretti G, Shen Q, Lia M, et al. (2006) Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat Immunol 7: 773-782 doi:10.1038/ni1357.
8. Alinikula J, Nera K-P, Junttila S, Lassila O, (2011) Alternate pathways for Bcl6-mediated regulation of B cell to plasma cell differentiation. Eur J Immunol doi:10.1002/eji.201141553.
9. Diehl SA, Schmidlin H, Nagasawa M, van Haren SD, Kwakkenbos MJ, et al. (2008) STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation. J Immunol 180: 4805-4815.
10. Cattoretti G, Shaknovich R, Smith PM, Jäck H-M, Murty VV, et al. (2006) Stages of germinal center transit are defined by B cell transcription factor coexpression and relative abundance. 177: 6930-6939.
11. Oracki SA, Walker JA, Hibbs ML, Corcoran LM, Tarlinton DM, (2010) Plasma cell development and survival. Immunol Rev 237: 140-159 doi:10.1111/j.1600-065X.2010.00940.x.
12. Cattoretti G, Chang CC, Cechova K, Zhang J, Ye BH, et al. (1995) BCL-6 protein is expressed in germinal-center B cells. Blood 86: 45-53.
13. Blobel CP, (2005) ADAMs: key components in EGFR signalling and development. Nat Rev Mol Cell Biol 6: 32-43 doi:10.1038/nrm1548.
14. Crawford HC, Dempsey PJ, Brown G, Adam L, Moss ML, (2009) ADAM10 as a therapeutic target for cancer and inflammation. Curr Pharm Des 15: 2288-2299.
15. Tousseyn T, Thathiah A, Jorissen E, Raemaekers T, Konietzko U, et al. (2008) ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the-Secretase. Journal of Biological Chemistry 284: 11738-11747 doi:10.1074/jbc.M805894200.
16. Gibb DR, Saleem SJ, Chaimowitz NS, Mathews JA, Conrad DH, (2011) The emergence of ADAM10 as a regulator of lymphocyte development and autoimmunity. Mol Immunol doi:10.1016/j.molimm.2010.12.005.
17. Gibb DR, Shikh el MEM, Kang D-J, Rowe WJ, Sayed el RM, et al. (2010) ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo. Journal of Experimental Medicine 207: 623-635 doi:10.1084/jem.20091990.
18. Tian L, Wu X, Chi C, Han M, Xu T, et al. (2008) ADAM10 is essential for proteolytic activation of Notch during thymocyte development. Int Immunol 20: 1181-1187 doi:10.1093/intimm/dxn076.
19. Chaimowitz NS, Martin RK, Cichy J, Gibb DR, Patil P, et al. (2011) A Disintegrin and Metalloproteinase 10 Regulates Antibody Production and Maintenance of Lymphoid Architecture. J Immunol doi:10.4049/jimmunol.1102172.
20. Casola S, Cattoretti G, Uyttersprot N, Koralov SB, Seagal J, et al. (2006) Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Proc Natl Acad Sci USA 103: 7396-7401 doi:10.1073/pnas.0602353103.
21. Todd DJ, McHeyzer-Williams LJ, Kowal C, Lee A-H, Volpe BT, et al. (2009) XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development. Journal of Experimental Medicine 206: 2151-2159 doi:10.1084/jem.20090738.
22. Overall CM, Blobel CP, (2007) In search of partners: linking extracellular proteases to substrates. Nat Rev Mol Cell Biol 8: 245-257 doi:10.1038/nrm2120.
23. Ozaki K, Spolski R, Ettinger R, Kim H-P, Wang G, et al. (2004) Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol 173: 5361-5371.
24. Calame KL, Lin K-I, Tunyaplin C, (2003) Regulatory mechanisms that determine the development and function of plasma cells. Annu Rev Immunol 21: 205-230 doi:10.1146/annurev.immunol.21.120601.141138.
25. Shaffer AL, Shapiro-Shelef M, Iwakoshi NN, Lee A-H, Qian S-B, et al. (2004) XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity 21: 81-93 doi:10.1016/j.immuni.2004.06.010.
26. Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, et al. (2009) Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325: 1006-1010 doi:10.1126/science.1175870.
27. Soro PG, Morales-A P, Martínez-M JA, Morales-A S, Copín SG, et al. (1999) Differential involvement of the transcription factor Blimp-1 in T cell-independent and-dependent B cell differentiation to plasma cells. J Immunol 163: 611-617.
28. Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM, (1997) Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276: 589-592.
29. Pone EJ, Zhang J, Mai T, White CA, Li G, et al. (2012) BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway. Nat Comms 3: 767 doi:10.1038/ncomms1769.
30. Pasare C, Medzhitov R, (2005) Control of B-cell responses by Toll-like receptors. Nature 438: 364-368 doi:10.1038/nature04267.
31. Tanigaki K, Han H, Yamamoto N, Tashiro K, Ikegawa M, et al. (2002) Notch{pipe}[ndash]{pipe}RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol 3: 443-450 doi:doi:10.1038/ni793.
32. Saito T, Chiba S, Ichikawa M, Kunisato A, Asai T, et al. (2003) Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity 18: 675-685.
33. Sakurai N, Maeda M, Lee S-U, Ishikawa Y, Li M, et al. (2011) The LRF transcription factor regulates mature B cell development and the germinal center response in mice. J Clin Invest doi:10.1172/JCI45682.
34. Hampel F, Ehrenberg S, Hojer C, Draeseke A, Marschall-Schröter G, et al. (2011) CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling. Blood doi:10.1182/blood-2010-12-325944.
35. Santos MA, Sarmento LM, Rebelo M, Doce AA, Maillard I, et al. (2007) Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells. Proc Natl Acad Sci USA 104: 15454-15459 doi:10.1073/pnas.0702891104.
36. Thomas M, Calamito M, Srivastava B, Maillard I, Pear WS, et al. (2007) Notch activity synergizes with B-cell-receptor and CD40 signaling to enhance B-cell activation. Blood 109: 3342-3350 doi:10.1182/blood-2006-09-046698.
37. Matthews V, Schuster B, Schütze S, Bussmeyer I, Ludwig A, et al. (2003) Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). J Biol Chem 278: 38829-38839 doi:10.1074/jbc.M210584200.
38. Nurieva RI, Chung Y, Martinez GJ, Yang XO, Tanaka S, et al. (2009) Bcl6 mediates the development of T follicular helper cells. Science 325: 1001-1005 doi:10.1126/science.1176676.
39. Tsuyama N, Danjoh I, Otsuyama K-I, Obata M, Tahara H, et al. (2005) IL-6-induced Bcl6 variant 2 supports IL-6-dependent myeloma cell proliferation and survival through STAT3. Biochem Biophys Res Commun 337: 201-208 doi:10.1016/j.bbrc.2005.09.036.
40. Wu Y, Shikh el MEM, Sayed el RM, Best AM, Szakal AK, et al. (2009) IL-6 produced by immune complex-activated follicular dendritic cells promotes germinal center reactions, IgG responses and somatic hypermutation. Int Immunol 21: 745-756 doi:10.1093/intimm/dxp041.
41. Arima T, Enokida H, Kubo H, Kagara I, Matsuda R, et al. (2007) Nuclear translocation of ADAM-10 contributes to the pathogenesis and progression of human prostate cancer. Cancer Science 98: 1720-1726 doi:10.1111/j.1349-7006.2007.00601.x.
42. Hobeika E, Thiemann S, Storch B, Jumaa H, Nielsen PJ, et al. (2006) Testing gene function early in the B cell lineage in mb1-cre mice. Proc Natl Acad Sci USA 103: 13789-13794 doi:10.1073/pnas.0605944103.
43. Vu F, Dianzani U, Ware CF, Mak T, Gommerman JL, (2008) ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reaction. J Immunol 180: 2284-2293.
44. Aiba Y, Kometani K, Hamadate M, Moriyama S, Sakaue-Sawano A, et al. (2010) Preferential localization of IgG memory B cells adjacent to contracted germinal centers. Proc Natl Acad Sci USA 107: 12192-12197 doi:10.1073/pnas.1005443107.
45. Caven TH, Shelburne A, Sato J, Chan-Li Y, Becker S, et al. (2005) IL-21 dependent IgE production in human and mouse in vitro culture systems is cell density and cell division dependent and is augmented by IL-10. Cell Immunol 238: 123-134 doi:10.1016/j.cellimm.2006.03.001.