Uliginosin B presents antinociceptive effect mediated by dopaminergic and opioid systems in mice

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 39, Issue 1, 2012, Pages 80-87

  Stolz, Eveline Dischkaln ^a   Viana, Alice Fialho ^a   Hasse, Diego Rafael ^a   von Poser, Gilsane Lino ^a   do Rego, Jean Claude ^b   Rates, Stela M K ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSITÉ DE ROUEN   (France)

Author keywords

Antinociceptive; Hypericum; Phloroglucinol; Uliginosin B

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; CODEINE; DIPYRONE; DOPAMINE RECEPTOR; HALOPERIDOL; MORPHINE; NALOXONE; OPIATE RECEPTOR; PARACETAMOL; PHLOROGLUCINOL DERIVATIVE; SULPIRIDE; ULIGINOSIN B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME INHIBITION; HOT PLATE TEST; MALE; MOTOR COORDINATION; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; WRITHING TEST;

ANALGESICS; ANIMALS; BENZAZEPINES; BRAIN; DOPAMINE ANTAGONISTS; DRUG INTERACTIONS; MALE; MICE; MICE, INBRED STRAINS; NALOXONE; NARCOTIC ANTAGONISTS; PAIN MEASUREMENT; PHLOROGLUCINOL; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE; RECEPTORS, OPIOID; ROTAROD PERFORMANCE TEST; SULPIRIDE;

EID: 84864509476     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2012.05.012     Document Type: Article

References (70)

1. Abdel-Salam O. Anti-inflammatory, antinociceptive, and gastric effects of Hypericum perforatum in rats. ScientificWorldJournal 2005, 5:586-595.
2. Altier N., Stewart J. Intra-VTA infusions of the substance P analogue, DiMe-C7, and intra-accumbens infusions of amphetamine induce analgesia in the formalin test for tonic pain. Brain Res 1993, 628:279-285.
3. Altier N., Stewart J. Opioid receptors in the ventral tegmental area contribute to stress-induced analgesia in the formalin test for tonic pain. Brain Res 1996, 718:203-206.
4. Altier N., Stewart J. Dopamine receptor antagonists in the nucleus accumbens attenuate analgesia induced by ventral tegmental area substance P or morphine and by nucleus accumbens amphetamine. J Pharmacol Exp Ther 1998, 285:208-215.
5. Ambrose L., Unterwald E., Van Bockstaele E. Ultrastructural evidence for co-localization of dopamine D2 and mu-opioid receptors in the rat dorsolateral striatum. Anat Rec A Discov Mol Cell Evol Biol 2004, 279A:583-591.
6. Ambrose L., Gallagher S., Unterwald E., Van Bockstaele E. Dopamine-D1 and delta-opioid receptors co-exist in rat striatal neurons. Neurosci Lett 2006, 399:191-196.
7. Bankowski Z., Howard-Jones N. Intarnational guiding principles for biomedical research involving animals 1985, Council for International Organization of Medical Sciences (CIOMS), Avaiable in: http://www.cioms.ch/publications/guidelines/1985_texts_of_guidelines.htm.
8. Brasil C.N. Lei procedimentos para o uso científico de animais. Lei n. 11794, Diário Oficial da União (DOU): 8 de outubro de 2008 2008.
9. Capasso R., Borrelli F., Capasso F., Mascolo N., Izzo A. Inhibitory effect of the antidepressant St. John's wort (Hypericum perforatum) on rat bladder contractility in vitro. Urology 2004, 64:168-172.
10. Cargill G., Salin B., Lubin S., Kohler F., Coste T., Rautureau J. Effects of phloroglucinol on rectosigmoid motricity stimulated by a test meal - a study in subjects with irritable bowel syndrome. Presse Med 1992, 21:19-23.
11. Cervo L., Mennini T., Rozio M., Ekalle-Soppo C., Canetta A., Burbassi S., et al. Potential antidepressant properties of IDN 5491 (hyperforin-trimethoxybenzoate), a semisynthetic ester of hyperforin. Eur Neuropsychopharmacol 2005, 15:211-218.
12. Chassany O., Bonaz B., Des Varannes S., Bueno L., Cargill G., Coffin B., et al. Acute exacerbation of pain in irritable bowel syndrome: efficacy of phloroglucinol/trimethylphloroglucinol - a randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther 2007, 25:1115-1123.
13. Chatterjee S., Filippov V., Lishko P., Maximyuk O., Noldner M., Krishtal O. Hyperforin attenuates various ionic conductance mechanisms in the isolated hippocampal neurons of rat. Life Sci 1999, 65:2395-2405.
14. Densmore V.S., Kalous A., Keast J.R., Osborne P.B. Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin. Pain 2010, 151:184-193.
15. Directive E.C.C. Law 609 1986, vol. 609/EEC.
16. Ducrotte P., Dapoigny M., Bonaz B., Siproudhis L. Symptomatic efficacy of beidellitic montmorillonite in irritable bowel syndrome: a randomized, controlled trial. Aliment Pharmacol Ther 2005, 21:435-444.
17. Eckert G., Keller J., Jourdan C., Karas M., Volmer D., Schubert-Zsilavecz M., et al. Hyperforin modifies neuronal membrane properties in vivo. Neurosci Lett 2004, 367:139-143.
18. Ferraz A.B.F., Schripsema J., Pohlmann A.R., von Poser G.L. Uliginosin B from Hypericum myrianthum Cham. & Schltdl. Biochem Syst Ecol 2002, 30:989-991.
19. Fisunov A., Lozovaya N., Tsintsadze T., Chatterjee S., Noldner M., Krishtal O. Hyperforin modulates gating of P-type Ca2+ current in cerebellar purkinje neurons. Pflugers Arch 2000, 440:427-434.
20. Galeotti N., Vivoli E., Bilia A., Bergonzi M., Bartolini A., Ghelardini C. A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of St John's wort in mice. J Pain 2010, 11:149-159.
21. Gobbi M., Moia M., Pirona L., Morizzoni P., Mennini T. In vitro binding studies with two Hypericum perforatum extracts-hyperforin, hypericin and biapigenin-on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters. Pharmacopsychiatry 2001, 34(Suppl. 1):S45-S48.
22. Gray A., Spencer P., Sewell R. The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds. Br J Pharmacol 1998, 124:669-674.
23. Guay D.R. Is tapentadol an advance on tramadol?. Consult Pharm 2009, 24:833-840.
24. Haas J., Viana A., Heckler A., von Poser G., Rates S. The antinociceptive effect of a benzopyran (HP1) isolated from Hypericum polyanthemum in mice hot-plate test is blocked by naloxone. Planta Med 2010, 76:1419-1423.
25. Haas J., Stolz E., Betti A., Stein A., Schripsema J., von Poser G., et al. The anti-Immobility effect of hyperoside on the forced swimming test in rats is mediated by the D2-like receptors activation. Planta Med 2011, 77:334-339.
26. Jafri W., Yakoob J., Hussain S., Jafri N., Islam M. Phloroglucinol in irritable bowel syndrome. J Pak Med Assoc 2006, 56(1):5-8.
27. Jayasuriya H., Clark A., Mc Chesney J. New antimicrobial filicinic acid-derivatives from Hypericum drummondii. J Nat Prod 1991, 54:1314-1320.
28. Kamei J., Saitoh A. Involvement of dopamine D2 receptor-mediated functions in the modulation of morphine-induced antinociception in diabetic mouse. Neuropharmacology 1996, 35:273-278.
29. King M., Bradshaw S., Chang A., Pintar J., Pasternak G. Potentiation of opioid analgesia in dopamine(2) receptor knock-out mice: evidence for a tonically active anti-opioid system. J Neurosci 2001, 21:7788-7792.
30. Kumar V., Mdzinarishvili A., Kiewert C., Abbruscato T., Bickel U., van der Schyf C., et al. NMDA receptor-antagonistic properties of hyperforin, a constituent of St. John's wort. J Pharmacol Sci 2006, 102:47-54.
31. Lahlou S. Involvement of spinal dopamine receptors in mediation of the hypotensive and bradycardic effects of systemic quinpirole in anaesthetised rats. Eur J Pharmacol 1998, 353:227-237.
32. Le Bars D., Gozariu M., Cadden S. Animal models of nociception. Pharmacol Rev 2001, 53:597-652.
33. Leal K., Yoneda J., Lindgren E., Pinheiro C., Correa A., Franca H. Conformational analysis of phloroglucinols from Hypericum brasiliense by using X-ray diffraction and molecular modeling. J Braz Chem Soc 2010, 21:837-841.
34. Linde K., Berner M., Kriston L. St John's wort for major depression. Cochrane Database Syst Rev 2008, 4:CD000448.
35. Lowry O., Rosebrough N., Farr A., Randall R. Protein measurement with folin phenol reagent. Current contents 1977, 7-7.
36. Magnusson J., Fisher K. The involvement of dopamine in nociception: the role of D-1 and D-2 receptors in the dorsolateral striatum. Brain Res 2000, 855:260-266.
37. Mennini T., Gobbi M. The antidepressant mechanism of Hypericum perforatum. Life Sci 2004, 75:1021-1027.
38. Meyer P., Morgan M., Kozell L., Ingram S. Contribution of dopamine receptors to periaqueductal gray-mediated antinociception. Psychopharmacology 2009, 204:531-540.
39. Millan M. Descending control of pain. Prog Neurobiol 2002, 66:355-474.
40. Muller W., Singer A., Wonnemann M. Hyperforin - antidepressant activity by a novel mechanism of action. Pharmacopsychiatry 2001, 34:S98-S102.
41. Munro G. Dopamine D(1) and D(2) receptor agonism enhances antinociception mediated by the serotonin and noradrenaline reuptake inhibitor duloxetine in the rat formalin test. Eur J Pharmacol 2007, 575:66-74.
42. Müller W.E. Current St John's wort research from mode of action to clinical efficacy. Pharmacol Res 2003, 47:101-109.
43. Nor C., Albring D., Ferraz A., Schripsema J., Pires V., Sonnet P., et al. Phloroglucinol derivatives from four Hypericum species belonging to the Trigynobrathys section. Biochem Syst Ecol 2004, 32:517-519.
44. Nor C., Bernardi A., Haas J., Schripsema J., Rech S., von Poser G. Phenolic constituents of Hypericum flowers. Nat Prod Commun 2008, 3:237-240.
45. Nunes J., Pinhatti A., von Poser G., Rech S. Promotive effects of long-term fertilization on growth of tissue culture-derived Hypericum polyanthemum plants during acclimatization. Ind Crops Prod 2009, 30:329-332.
46. Pedersen L., Nielsen A., Blackburn-Munro G. Anti-nociception is selectively enhanced by parallel inhibition of multiple subtypes of monoamine transporters in rat models of persistent and neuropathic pain. Psychopharmacology 2005, 182:551-561.
47. Pelissier T., Laurido C., Hernandez A., Constandil L., Eschalier A. Biphasic effect of apomorphine on rat nociception and effect of dopamine D2 receptor antagonists. Eur J Pharmacol 2006, 546:40-47.
48. Pellissier G., Demenge P. Hypotensive and bradycardic effects elicited by spinal dopamine receptor stimulation - effects of D1-receptor and D2-receptor agonists and antagonists. J Cardiovasc Pharmacol 1991, 18:548-555.
49. Plummer J., Cmielewski P., Gourlay G., Owen H., Cousins M. Assessment of antinociceptive drug effects in the presence of impaired motor-performance. J Pharmacol Methods 1991, 26:79-87.
50. Ripoll N., Hascoet M., Bourin M. The four-plates test: anxiolytic or analgesic paradigm?. Prog Neuropsychopharmacol Biol Psychiatry 2006, 30:873-880.
51. Rocha L., Marston A., Potterat O., Kaplan M., Evans H., Hostettmann K. Antibacterial phloroglucinols and flavonoids from Hypericum brasiliense. Phytochemistry 1995, 40:1447-1452.
52. Rocha L., Marston A., Potterat O., Kaplan M., Hostettmann K. More phloroglucinols from Hypericum brasiliense. Phytochemistry 1996, 42:185-188.
53. Saddiqe Z., Naeem I., Maimoona A. A review of the antibacterial activity of Hypericum perforatum L. J Ethnopharmacol 2010, 131:511-521.
54. Sardella A., Lodi G., Demarosi F., Tarozzi M., Canegallo L., Carrassi A. Hypericum perforatum extract in burning mouth syndrome: a randomized placebo-controlled study. J Oral Pathol Med 2008, 37:395-401.
55. Singer A., Wonnemann M., Muller W. Hyperforin, a major antidepressant constituent of St. John's wort, inhibits serotonin uptake by elevating free intracellular Na+. J Pharmacol Exp Ther 1999, 290:1363-1368.
56. Soderman A., Unterwald E. Cocaine-induced mu opioid receptor occupancy within the striatum is mediated by dopamine D2 receptors. Brain Res 2009, 1296:63-71.
57. Spetea M., Bohotin C., Asim M., Stubegger K., Schmidhammer H. In vitro and in vivo pharmacological profile of the 5-benzyl analogue of 14-methoxymetopon, a novel mu opioid analgesic with reduced propensity to alter motor function. Eur J Pharm Sci 2010, 41:125-135.
58. Stein A.C., Viana A.F., Müller L.G., Nunes J.M., Stolz E.D., Do Rego J.C., et al. Uliginosin B, a phloroglucinol derivative from Hypericum polyanthemum: a promising new molecular pattern for the development of antidepressant drugs. Behav Brain Res 2012, 228(1):66-73.
59. Tu P., Gibon J., Bouron A. The TRPC6 channel activator hyperforin induces the release of zinc and calcium from mitochondria. J Neurochem 2010, 112:204-213.
60. Viana A., do Rego J., von Poser G., Ferraz A., Heckler A., Costentin J., et al. The antidepressant-like effect of Hypericum caprifoliatum Cham & Schlecht (Guttiferae) on forced swimming test results from an inhibition of neuronal monoamine uptake. Neuropharmacology 2005, 49:1042-1052.
61. Viana A., do Rego J., Munari L., Dourmap N., Heckler A., Dalla Costa T., et al. Hypericum caprifoliatum (Guttiferae) Cham. & Schltdl.: a species native to South Brazil with antidepressant-like activity. Fundam Clin Pharmacol 2006, 20:507-514.
62. Viana A.F., Heckler A.P., Fenner R., Rates S.M. Antinociceptive activity of Hypericum caprifoliatum and Hypericum polyanthemum (Guttiferae). Braz J Med Biol Res 2003, 36:631-634.
63. Voller J., Donek A., Cendelń J., Korelusová I., Vozeh F. The effect of D1-like receptor blockade on motor functions and spatial learning in B6CBA mice. Prague Med Rep 2008, 109:32-39.
64. Weilfugazza J., Godefroy F. Further evidence for the involviment of the diencephalo-dopaminergic system in pain modulation - a neurochemical study on the effect of morphine in the arthritic rat. Int J Tissue React 1991, 13:305-310.
65. Weizman T., Pick C., Backer M., Rigai T., Bloch M., Schreiber S. The antinociceptive effect of amisulpride in mice is mediated through opioid mechanisms. Eur J Pharmacol 2003, 478:155-159.
66. Wonnemann M., Singer A., Muller W. Inhibition of synaptosomal uptake of H-3-L-glutamate and H-3-GABA by hyperforin, a major constituent of St. John's wort: the role of amiloride sensitive sodium conductive pathways. Neuropsychopharmacology 2000, 23:188-197.
67. Wood P.B. Role of central dopamine in pain and analgesia. Expert Rev Neurother 2008, 8:781-797.
68. Yasuda T., Miki S., Yoshinaga N., Senba E. Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy. Pain 2005, 115:161-170.
69. Zanoli P., Rivasi M., Zavatti M., Brusiani F., Baraldi M. New insight in the neuropharmacological activity of Humulus lupulus L. J Ethnopharmacol 2005, 102:102-106.
70. Zarrindast M., Nassiri-Rad S., Pazouki M. Effects of dopaminergic agents on antinociception in formalin test. Gen Pharm Vasc Syst 1999, 32:517-522.