NMDA receptor-antagonistic properties of hyperforin, a constituent of St. John's wort

Journal of Pharmacological Sciences

Volumn 102, Issue 1, 2006, Pages 47-54

  Kumar, Vikas ^a   Mdzinarishvili, Alexander ^a   Kiewert, Cornelia ^a   Abbruscato, Thomas ^a   Bickel, Ulrich ^a   Van Der Schyf, Cornelis J ^a   Klein, Jochen ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Edema; Fura 2; Hippocampal slice; Middle cerebral artery occlusion; Water intoxication

Indexed keywords

CHOLINE; HYPERFORIN; HYPERICUM PERFORATUM EXTRACT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHOSPHOLIPID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN EDEMA; BRAIN WATER; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FEMALE; HIPPOCAMPUS; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; RAT; WATER INTOXICATION;

EID: 33748986155     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FP0060378     Document Type: Article

References (44)

1. Linde K, Ramirez G, Mulrow CD, Pauls A, Weidenhammer W, Melchart D. St. John's wort for depression - an overview and meta-analysis of randomised clinical trials. Br Med J. 1996;313:253-258.
2. Kumar V, Singh PN, Muruganandam AV, Bhattacharya SK. Hypericum perforatum: nature's mood stabilizer. Indian J Exp Biol. 2000;38:1077-1085.
3. DiCarlo G, Borrelli F, Ernst E, Izzo AA. St. John's wort: prozac from the plant kingdom. Trends Pharmacol Sci. 2001;22:292-297.
4. Kumar V, Jaiswal AK, Singh PN, Bhattacharya SK. Anxiolytic activity of Indian Hypericum perforatum Linn: an experimental study. Indian J Exp Biol. 2000;38:36-41.
5. Zanoli P. Role of hyperforin in the pharmacological activities of St. John's Wort. CNS Drug Rev. 2004;10:203-218.
6. Butterweck V. Mechanism of action of St. John's wort in depression: what is known? CNS Drugs. 2003;17:539-562.
7. Müller WE. Current St John's wort research from mode of action to clinical efficacy. Pharmacol. Res. 2003;47:101-109.
8. Kiewert C, Buchholzer ML, Hartmann J, Chatterjee SS, Klein J. Stimulation of hippocampal acetylcholine release by hyperforin, a constituent of St. John's wort. Neurosci Lett. 2004;364:195-198.
9. Kaehler ST, Sinner C, Chatterjee SS, Philippu A. Hyperforin enhances the extracellular concentrations of catecholamines, serotonin and glutamate in the rat locus coeruleus. Neurosci Lett. 1999;262:199-202.
10. Treiber K, Singer A, Henke B, Müller WE. Hyperforin activates nonselective cation channels (NSCCs). Br J Pharmacol. 2005;145:75-83.
11. Chatterjee SS, Filippov V, Lishko P, Maximyuk O, Nöldner M, Krishtal O. Hyperforin attenuates various ionic conductance mechanisms in the isolated hippocampal neurons of rat. Life Sci. 1999;65:2395-2405.
12. 2+ current in cerebellar Purkinje neurons. Pflugers Arch, Eur J Physiol. 2000;440:427-434.
13. Chatterjee SS, Erdelmeier C, Klessing K. Stable hyperforin salts: method for producing them and their use in the treatment of Alzheimer's disease. Int Pat. 1999;PCT Wo 99/41220.
14. Kiewert C, Hartmann J, Stoll J, Thekkumkara TJ, van der Schyf CJ, Klein J. NGP1-01 is a brain-permeable dual blocker of neuronal voltage- and ligand-operated calcium channels. Neurochem Res. 2006;31:395-399.
15. 2 activation and phospholipid breakdown in rat hippocampus. Naunyn Schmiedebergs Arch Pharmacol. 1999;360:609-615.
16. Klein J, Weichel O, Hilgert M, Rupp J, Chatterjee SS, Nawrath H. Excitotoxic hippocampal membrane breakdown and its inhibition by bilobalide: role of chloride fluxes. Pharmacopsychiatry. 2003;36 Suppl 1:S78-S83.
17. Mdzinarishvili A, Geldenhuys WJ, Abbruscato TJ, Bickel U, Klein J, Van der Schyf CJ. NGP1-01, a lipophilic polycyclic cage amine, is neuroprotective in focal ischemia. Neurosci Lett. 2005;383:49-53.
18. Elliott KC, Jaspar H. Measurement of experimentally induced brain swelling and shrinkage. Am J Physiol. 1949;157:122-129.
19. Sydserff SG, Green AR, Cross AJ. The effect of oedema and tissue swelling on the measurement of neuroprotection; a study using chlormethiazole and permanent middle cerebral artery occlusion in rats. Neurodegeneration. 1996;5:81-85.
20. Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, et al. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nature Med. 2000;6:159-163.
21. Amiry-Moghaddam M, Xue R, Haug FM, Neely JD, Bhardwaj A, Agre P, et al. Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia. FASEB J. 2004;18:542-544.
22. Rudolf R, Mongillo M, Rizzuto R, Pozzan T. Looking forward to seeing calcium. Nature Rev Mol Cell Biol. 2003;4:579-586.
23. Klein J. Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids. J Neural Transm. 2000;107:1027-1063.
24. + and water during the first two hours of in vitro incubation of hippocampal slices. Neuroscience. 1997;79:1013-1022.
25. LoPachin RM, Gaughan CL, Lehning EJ, Weber ML, Taylor CP. Effects of ion channel blockade on the distribution of Na, K, Ca and other elements in oxygen-glucose deprived CA1 hippocampal neurons. Neuroscience. 2001;103:971-983.
26. MacGregor DG, Avshalumov MV, Rice ME. Brain edema induced by in vitro ischemia: causal factors and neuroprotection. J Neurochem. 2003;85:1402-1411.
27. Hunt EJ, Lester CE, Lester EA, Tackett RL. Effect of St. John's wort on free radical production. Life Sci. 2001;69:181-190.
28. Gozlan H, Ben-Ari Y. NMDA receptor redox sites: are they targets for selective neuronal protection? Trends Pharmacol Sci. 1995;16:368-374.
29. Lee J-M, Zipfel GJ, Choi DW. The changing landscape of ischemic brain injury mechanisms. Nature. 1999;399 Suppl:A7-A14.
30. Krishtal O, Lozovaya N, Fisunov A, Tsintsadze T, Pankratov Y, Kopanitsa M, et al. Modulation of ion channels in rat neurons by the constituents of Hypericum perforatum. Pharmacopsychiatry. 2001;34 Suppl 1:S74-S82.
31. Lipton P. Ischemic cell death in brain neurons. Physiol Rev. 1999;79:1431-1568.
32. Kemp JA, McKernan RM. NMDA receptor pathways as drug targets. Nature Neurosci. 2002;Suppl 5:1039-1042.
33. Arundine M, Tymianski M. Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury. Cell Mol Life Sci. 2004;61:657-668.
34. Jang MH, Lee TH, Shin MC, Bahn GH, Kim JW, Shin DH, et al. Protective effect of Hypericum perforatum Linn (St. John's wort) against hydrogen peroxide-induced apoptosis on human neuroblastoma cells. Neurosci Lett. 2002;329:177-180.
35. Benedi J, Arroyo R, Romero C, Martin-Aragon S, Villar AM. Antioxidant properties and protective effects of a standardized extract of Hypericum perforatum on hydrogen peroxide-induced oxidative damage in PC12 cells. Life Sci. 2004;75:1263-1276.
36. LaFerla FM. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nature Rev Neurosci. 2002;3:862-872.
37. Keller JH, Karas M, Müller WE, Volmer DA, Eckert GP, Tawab MA, et al. Determination of hyperforin in mouse brain by high-performance liquid chromatography/tandem mass spectrometry. Anal Chem. 2003;75:6084-6088.
38. Eckert GP, Keller J-H, Jourdan C, Karas M, Volmer DA, Schubert-Zsilavecz M, et al. Hyperforin modifies neuronal membrane properties in vivo. Neurosci Lett. 2004;367:139-143.
39. Silva BA, Dias AC, Ferreres F, Malva JO, Oliveira CR. Neuroprotective effect of H. perforatum extracts on beta-amyloid-induced neurotoxicity. Neurotox Res. 2004;6:119-130.
40. De Vry J, Maurel S, Schreiber R, de Beun R, Jentzsch KR. Comparison of hypericum extracts with imipramine and fluoxetine in animal models of depression and alcoholism. Eur Neuropsychopharmacol. 1999;9:461-468.
41. Perfumi M, Ciccocioppo R, Angeletti S, Cucculelli M, Massi M. Effects of Hypericum perforatum extract on alcohol intake in Marchigian Sardinian alcohol-preferring rats. Alcohol Alcohol. 1999;34:690-698.
42. Rezvani AH, Overstreet DH, Yang Y, Clark E Jr. Attenuation of alcohol intake by extract of Hypericum perforatum (St. John's Wort) in two different strains of alcohol-preferring rats. Alcohol Alcohol. 1999;34:699-705.
43. Wright CW, Gott M, Grayson B, Hanna M, Smith AG, Sunter A, et al. Correlation of hyperforin content of Hypericum perforatum (St John's wort) extracts with their effects on alcohol drinking in C57BL/6J mice: a preliminary study. J Psychopharmacol. 2003;17:403-408.
44. 2 extract on the motivational properties of ethanol in alcohol-preferring rats. Alcohol Alcohol. 2005;40:291-296.