Amygdala Functional Connectivity Predicts Pharmacotherapy Outcome in Pediatric Bipolar Disorder

Brain Connectivity

Volumn 1, Issue 5, 2011, Pages 411-422

  Wegbreit, Ezra ^a   Ellis, James A ^a   Nandam, Aneesh ^a   Fitzgerald, Jacklynn M ^a   Passarotti, Alessandra M ^a   Pavuluri, Mani N ^a   Stevens, Michael C ^b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

affective disorders; brain connectivity; cognition; pharmacology

Indexed keywords

EID: 84864471368     PISSN: 21580014     EISSN: 21580022     Source Type: Journal    
DOI: 10.1089/brain.2011.0035     Document Type: Article

References (59)

1. Anand A, Li Y, Wang W, Lowe M.J., Dzemidzic M. 2009. Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression. Psychiatry Res Neuroimaging 171:189-198.
2. Arribas J.I., Calhoun V.D., et al. 2010. Automatic Bayesian classification of healthy controls, bipolar disorder, and schizophrenia using intrinsic connectivity maps from fMRI data. IEEE Trans Biomed Eng 57:2850-2860.
3. Bell A.J., Sejnowski TJ. 1995. An information maximization approach to blind separation and blind deconvolution. Neural Comput 7:1129-1159.
4. Birmaher B.D., Axelson D, Goldstein B, Strober M, Gill M.K., Hunt J, Houck P, Ha W, Ivengar S, Kim E, Yen S, Hower H, Esposito-Smythers C, Goldsten T, Ryan N, Keller M. 2009. Four-year longitudinal course of children and adolescents with bipolar spectrum disorders: the Course and Outcome of Bipolar Youth (COBY) Study. Am J Psychiatry 166:795-804.
5. Blumberg H.P., Martin A, Kaufman J, Leung H.C., Skudlarski P, Lacadie C, Fulbright R.K., Gore J.C., Charney D.S., Krystal J.H., Peterson BS. 2003. Frontostriatal abnormalities in adolescents with bipolar disorder: preliminary observations from functional MRI. Am J Psychiatry 160:1345-1347.
6. Bradley M.M., Lang PJ. 1999. Affective Norms for English words (ANEW): Stimuli, Instruction Manual and Affective Ratings. Technical Report C-1. Gainesville, FL: The Center for Research in Psychophysiology, University of Florida.
7. Brett M, Anton J, Valabregue R, Poline J. 2002. Region of Interest Analysis Using an SPM Toolbox. Abstract Presented at the the 8th International Conference on Functional Mapping of the Human Brain, June 2-6, Sendai, Japan, Available on CD-ROM in NeuroImage, Vol. 16, No. 2.
8. Bush G, Luu P, Posner MI. 2000. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 4:215-222.
9. Calhoun V.D., Adali T. 2006. Unmixing fMRI with independent component analysis: Using ICA to characterize high-dimensional fMRI data in a concise manner. IEEE Eng Med Biol Mag 25:79-90.
10. Calhoun V.D., Adali T, Pearlson G.D., Pekar JJ. 2001. A method for making group inferences from functional MRI data using independent component analysis. Hum Brain Mapp 14:140-151.
11. Calhoun V.D., Kiehl K.A., Pearlson GD. 2008a. Modulation of temporally coherent brain networks estimated using ICA at rest and during cognitive tasks. Hum Brain Mapp 29:828-838.
12. Calhoun V.D., Maciejewski P.K., Pearlson G.D., Kiehl KA. 2008b. Temporal lobe and “default” hemodynamic brain modes discriminate between schizophrenia and bipolar disorder. Hum Brain Mapp 29:1265-1275.
13. Chang K, Adleman N.E., Dienes K, Simeonova D.I., Menon V, Reiss A. 2004. Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder - a functional magnetic resonance imaging investigation. Arch Gen Psychiatry 61:781-792.
14. Chepenik L.G., Raffo M, Hampson M, Lacadie C, Wang F, Jones M.M., Pittman B, Skudlarski P, Blumberg HP. 2010. Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder. Psychiatry Res Neuroimaging 182:207-210.
15. Costafreda S.G., Brammer M.J., David A.S., Fu CH. 2008. Predictors of amygdala activation during the processing of emotional stimuli: a meta-analysis of 385 PET and fMRI studies. Brain Res Rev 58:57-70.
16. Dickstein D.P., Gorrostieta C, Ombao H, Goldberg L.D., Brazel A.C., Gable C.J., Kelly C, Gee D.G., Zuo X.N., Castellanos F.X., Milham MP. 2010. Fronto-temporal spontaneous resting state functional connectivity in pediatric bipolar disorder. Biol Psychiatry 68:839-846.
17. Dickstein D.P., Rich B.A., Roberson-Nay R, Berghorst L, Vinton D, Pine D.S., Leibenluft E. 2007. Neural activation during encoding of emotional faces in pediatric bipolar disorder. Bipolar Disord 9:679-692.
18. Eddy W.F., Fitzgerald M, Noll DC. 1996. Functional image analysis softwareâcomputational olio. In: Prat A (ed). Proceedings in Computational Statistics. Heidelberg: Physica-Verlag; pp. 39-49.
19. Erhardt E.B., Rachakonda S, Bedrick E.J., Allen E.A., Adali T, Calhoun VD. 2011. Comparison of multi-subject ICA methods for analysis of fMRI data. Hum Brain Mapp [Epub ahead of print]; DOI: 10.1002/hbm.21170.
20. Foland L.C., Altshuler L.L., Bookheimer S.Y., Eisenberger N, Townsend J, Thompson PM. 2008. Evidence for deficient modulation of amygdala response by prefrontal cortex in bipolar mania. Psychiatry Res Neuroimaging 162:27-37.
21. Friston K. 2002. Beyond phrenology: what can neuroimaging tell us about distributed circuitry? Annu Rev of Neurosci 25:221-250.
22. Geller B, Luby J. 1997. Child and adolescent bipolar disorder: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry 36:1168-1176.
23. Geller B, Warner K, Williams M, Zimerman B. 1998. Prepubertal and young adolescent bipolarity versus ADHD: assessment and validity using the WASH-UKSADS, CBCL, and TRF. J Affect Disord 51:93-100.
24. Gilhooly K.J., Logie RH. 1980. Age of acquisition, imagery, concreteness, familiarity and ambiguity measures for 1,944 words. Behav Res Methods Instrum 12:395-427.
25. Greicius M. 2008. Resting-state functional connectivity in neuropsychiatric disorders. Curr Opin Neurol 21: 424-430.
26. Hariri A.R., Tessitore A, Mattay V.S., Fera F, Weinberger DR. 2002. The amygdala response to emotional stimuli: a comparison of faces and scenes. Neuroimage 17:317-323.
27. Hart S.J., Green S.R., Casp M, Belger A. 2010. Emotional priming effects during Stroop task performance. NeuroImage 49:2662-2670.
28. Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N. 2000. Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 39:49-58.
29. Klein GS. 1964. Semantic power measured through the interference of words with color-naming. Am J Psychol 77:576-588.
30. Kowatch R.A., Delbello MP. 2005. Pharmacotherapy of children and adolescents with bipolar disorder. Psychiatr Clin North Am 28:385-397.
31. Leibenluft E, Rich B.A., Vinton D.T., Nelson E.E., Fromm S.J., Berghorst L.H., Joshi P, Robb A, Schachar R.J., Dickstein D.P., McClure E.B., Pine DS. 2007. Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder. Am J Psychiatry 164:52-60.
32. Li Y.O., Adali T, Calhoun VD. 2007. Estimating the number of independent components for functional magnetic resonance imaging data. Hum Brain Mapp 28:1251-1266.
33. Mayanil T, Wegbreit E, Fitzgerald J, Pavuluri M. 2011. Emerging biosignatures of brain function and intervention in pediatric bipolar disorder. Minerva Pediatr 63:183-200.
34. Nelson E.E., Vinton D.T., Berghorst L, Towbin K.E., Hommer R.E., Dickstein D.P., Rich B.A., Brotman M.A., Pine D.S., Leibenluft E. 2007. Brain systems underlying response flexibility in healthy and bipolar adolescents: an event-related fMRI study. Bipolar Disord 9:810-819.
35. Ochsner K.N., Ray R.D., Cooper J.C., Robertson E.R., Chopra S, Gabrieli J.D., Gross JJ. 2004. For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion. Neuroimage 23:483-499.
36. Passarotti A.M., Pavuluri MN. 2011. Brain functional domains inform therapeutic interventions in attention deficit/hyperactivity disorder and pediatric bipolar disorder. Exp Rev Neurother 11:897-914.
37. Passarotti A.M., Sweeney J.A., Pavuluri MN. 2009. Neural correlates of incidental and directed facial emotion processing in adolescents and adults. Soc Cogn Affect Neurosci 4:387-398.
38. Passarotti A.M., Sweeney J.A., Pavuluri MN. 2010a. Differential engagement of cognitive and affective neural systems in pediatric bipolar disorder and attention deficit hyperactivity disorder. J Int Neuropsychol Soc 16:106-117.
39. Passarotti A.M., Sweeney J.A., Pavuluri MN. 2010b. Emotion processing influences working memory circuits in pediatric bipolar disorder and attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 49:1064-1080.
40. Passarotti A.M., Sweeney J.A., Pavuluri MN. 2010c. Neural correlates of response inhibition in pediatric bipolar disorder and attention deficit hyperactivity disorder. Psychiatry Res Neuroimaging 181:36-43.
41. Passarotti A.M., Sweeney J.A., Pavuluri MN. 2011. Fronto-limbic dysfunction in mania pre-treatment and persistent amygdala over-activity post-treatment in pediatric bipolar disorder. Psychopharmacology 216:485-499.
42. Pavuluri M.N., Birmaher B, Naylor MW. 2005a. Pediatric bipolar disorder: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry 44:846-871.
43. Pavuluri M.N., Henry D.B., Carbray J.A., Naylor M.W., Janicak PG. 2005b. Divalproex sodium for pediatric mixed mania: a 6-month prospective trial. Bipolar Disord 7:266-273.
44. Pavuluri M.N., Henry D.B., Moss M, Mohammed T, Carbray J.A., Sweeney JA. 2009a. Effectiveness of lamotrigine in maintaining symptom control in pediatric bipolar disorder. J Child Adolesc Psychopharmacol 19:75-82.
45. Pavuluri M.N., O'Connor M.M., Harral E.M., Sweeney JA. 2007. Affective neural circuitry during facial emotion processing in pediatric bipolar disorder. Biol Psychiatry 62:158-167.
46. Pavuluri M.N., O'Connor M.M., Harral E.M., Sweeney JA. 2008. An fMRI study of the interface between affective and cognitive neural circuitry in pediatric bipolar disorder. Psychiatry Res Neuroimaging 162:244-255.
47. Pavuluri M.N., Passarotti AM. 2008. Neural bases of emotional processing in pediatric bipolar disorder. Exp Rev Neurotherap 8:1381-1387.
48. Pavuluri M.N., Passarotti A.M., Harral E.M., Sweeney JA. 2009b. An fMRI study of the neural correlates of incidental versus directed emotion processing in pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry 48:308-319.
49. Pavuluri M.N., Passarotti A.M., Lu L.H., Carbray J.A., Sweeney JA. 2011. Double-blind randomized trial of risperidone versus divalproex in pediatric bipolar disorder: fMRI outcomes. Psychiatry Res Neuroimaging 193:28-37.
50. Pavuluri M.N., Passarotti A.M., Parnes S.A., Fitzgerald J.M., Sweeney JA. 2010. A pharmacological functional magnetic resonance imaging study probing the interface of cognitive and emotional brain systems in pediatric bipolar disorder. J Child Adolesc Psychopharmacol 20:395-406.
51. Pavuluri M.N., Sweeney JA. 2008. Integrating functional brain neuroimaging and developmental cognitive neuroscience in child psychiatry research. J Am Acad Child Adolesc Psychiatry 47:1273-1288.
52. Pompei F, Dima D, Rubia K, Kumari V, Frangou S. 2011. Dissociable functional connectivity changes during the Stroop task relating to risk, resilience and disease expression in bipolar disorder. Neuroimage 57:576-582.
53. Poznanski E.O., Grossman J.A., Buchsbaum Y, Banegas M, Freeman L, Gibbons R. 1984. Preliminary studies of the reliability and validity of the children's depression rating scale. J Am Acad Child Adolesc Psychiatry 23:191-197.
54. Rich B.A., Fromm S.J., Berghorst L.H., Dickstein D.P., Brotman M.A., Pine D.S., Leibenluft E. 2008. Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit. J Child Psychol Psychiatry 49:88-96.
55. Rich B.A., Vinton D.T., Roberson-Nay R, Hommer R.E., Berghorst L.H., McClure E.B., Fromm S.J., Pine D.S., Leibenluft E. 2006. Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder. Proc Natl Acad Sci U S A 103:8900-8905.
56. Singh M.K., Chang K.D., Mazaika P, Garrett A, Adleman N, Kelley R, Howe M, Reiss A. 2010. Neural correlates of response inhibition in pediatric bipolar disorder. J Child Adolesc Psychopharmacol 20:15-24.
57. Wang F, Kalmar JH., He Y, Jackowski M, Chepenik L.G., Edmiston E.E., Tie K, Gong G, Shah M.P., Jones M, Uderman J, Constable R.T., Blumberg HP. 2009. Functional and structural connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder. Biol Psychiatry 66:516-521.
58. Worsley K.J., Marrett S, Neelin P, Vandal A.C., Friston K.J., Evans AC. 1996. A unified statistical approach for determining significant signals in images of cerebral activation. Hum Brain Mapp 4:58-73.
59. Young R.C., Biggs J.T., Ziegler V.E., Meyer DA. 1978. A rating scale for mania: reliability, validity, and sensitivity. Br J Psychiatry 133:429-435.