PIAS4 represses vitamin D receptor-mediated signaling and acts as an E3-SUMO ligase towards vitamin D receptor

Journal of Steroid Biochemistry and Molecular Biology

Volumn 132, Issue 1-2, 2012, Pages 24-31

  Jena, Sarita ^a   Lee, Wai Ping ^a   Doherty, Declan ^a   Thompson, Paul D ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

PIAS; Receptor; SUMO; Transcription; Vitamin D

Indexed keywords

CYTOCHROME; CYTOCHROME P450 24A1; CYTOCHROME P450 3A4; MESSENGER RNA; PROTEIN; PROTEIN INHIBITORS OF ACTIVATED STAT 4; RETINOID X RECEPTOR ALPHA; SUMO 1 PROTEIN; SUMO 2 PROTEIN; SUMO 3 PROTEIN; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ARTICLE; CELL STRAIN HEK293; CELL STRAIN MCF 7; CHROMATIN IMMUNOPRECIPITATION; FEMALE; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; PLEIOTROPY; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUMOYLATION; WESTERN BLOTTING;

CYTOCHROME P-450 CYP3A; HEK293 CELLS; HELA CELLS; HUMANS; PROTEIN INHIBITORS OF ACTIVATED STAT; RECEPTORS, CALCITRIOL; SIGNAL TRANSDUCTION; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; STEROID HYDROXYLASES; UBIQUITIN-PROTEIN LIGASES;

EID: 84864443491     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2012.04.006     Document Type: Article

References (31)

1. M.R. Haussler, C.A. Haussler, and L. Bartik Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention Nutrition Reviews 66 2008 S98 S112
2. M. Hewison Vitamin D and immune function: an overview Proceedings of the Nutrition Society 18 2011 1 12
3. J. Thorne, and M.J. Campbell The vitamin D receptor in cancer Proceedings of the Nutrition Society 67 2008 115 127 (Pubitemid 351543394)
4. M.R. Haussler, C.A. Haussler, and G.K. Whitfield The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the "Fountain of Youth" to mediate healthful aging Journal of Steroid Biochemistry and Molecular Biology 121 2010 88 97
5. N.J. McKenna, and B.W. O'Malley Combinatorial control of gene expression by nuclear receptors and coregulators Cell 108 2002 465 474 (Pubitemid 34260872)
6. H. Faus, and B. Haendler Post-translational modifications of steroid receptors Biomedicine and Pharmacotherapy 60 2006 520 528
7. P.D. Thompson, P.W. Jurutka, and C.A. Haussler Heterodimeric DNA binding by the vitamin D receptor and retinoid X receptors is enhanced by 1 25-dihydroxyvitamin D3 and inhibited by 9-cis-retinoic acid. Evidence for allosteric receptor interactions Journal of Biological Chemistry 273 1998 8483 8491 (Pubitemid 28168913)
8. P.W. Jurutka, P.N. MacDonald, and S. Nakajima Isolation of baculovirus-expressed human vitamin D receptor: DNA responsive element interactions and phosphorylation of the purified receptor Journal of Cellular Biochemistry 85 2002 435 457 (Pubitemid 34274910)
9. A. Murayama, M.S. Kim, and J. Yanagisawa Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching EMBO Journal 23 2004 1598 1608 (Pubitemid 38579520)
10. M.S. Kim, T. Kondo, and I. Takada DNA demethylation in hormone-induced transcriptional derepression Nature 461 2009 1007 1012
11. J.J. Palvimo PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcription Biochemical Society Transactions 35 2007 1405 1408
12. B. Liu, J. Liao, and X. Rao Inhibition of Stat1-mediated gene activation by PIAS1 Proceedings of the National Academy of Sciences of the United States of America 95 1998 10626 10631 (Pubitemid 28413118)
13. M. Gross, R. Yang, and I. Top PIASy-mediated repression of the androgen receptor is independent of sumoylation Oncogene 23 2004 3059 3066 (Pubitemid 38648196)
14. S. Sentis, M. Le Romancer, and C. Bianchin Sumoylation of the estrogen receptor alpha hinge region regulates its transcriptional activity Molecular Endocrinology 19 2005 2671 2684 (Pubitemid 41577242)
15. T. Ohshima, H. Koga, and K. Shimotohno Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification Journal of Biological Chemistry 279 2004 29551 29557 (Pubitemid 38915836)
16. M. Vidal, C.V. Ramana, and A.S. Dusso Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription Molecular and Cellular Biology 22 2002 2777 2787 (Pubitemid 34262998)
17. V. Dorval, and P.E. Fraser Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein Journal of Biological Chemistry 281 2006 9919 9924 (Pubitemid 43864524)
18. G. Bertilsson, A. Berkenstam, and P. Blomquist Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7 Biochemical and Biophysical Research Communications 280 2001 139 144 (Pubitemid 32917487)
19. J.C. Hsieh, G.K. Whitfield, and A.K. Oza Characterization of unique DNA-binding and transcriptional-activation functions in the carboxyl-terminal extension of the zinc finger region in the human vitamin D receptor Biochemistry 38 1999 16347 16358 (Pubitemid 129520558)
20. J.C. Hsieh, J.M. Sisk, and P.W. Jurutka Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling Journal of Biological Chemistry 278 2003 38665 38674 (Pubitemid 37229065)
21. B. Pourcet, I. Pineda-Torra, and B. Derudas SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR Journal of Biological Chemistry 285 2010 5983 5992
22. T. Ohshima, H. Koga, and K. Shimotohno Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification Journal of Biological Chemistry 279 2004 29551 29557 (Pubitemid 38915836)
23. E. Tolkunova, A. Malashicheva, and V.N. Parfenov PIAS proteins as repressors of Oct4 function Journal of Molecular Biology 374 2007 1200 1212 (Pubitemid 350122540)
24. C. Zhang, X. Yuan, and L. Yue PIASy interacts with p73alpha and regulates cell cycle in HEK293 cells Cellular Immunology 263 2010 235 240
25. X. Li, S. Zhang, and G. Blander SIRT1 deacetylates and positively regulates the nuclear receptor LXR Molecular Cell 28 2007 91 106 (Pubitemid 47531974)
26. S. Toropainen, S. Väisänen, and S. Heikkinen The down-regulation of the human MYC gene by the nuclear hormone 1alpha 25-dihydroxyvitamin D3 is associated with cycling of corepressors and histone deacetylases Journal of Molecular Biology 400 2010 284 294
27. A.K. Tse, G.Y. Zhu, and C.K. Wan 1alpha,25-Dihydroxyvitamin D3 inhibits transcriptional potential of nuclear factor kappa B in breast cancer cells Molecular Immunology 47 2010 1728 1738
28. M. Milovanovic, G. Heine, and W. Hallatschek Vitamin D receptor binds to the ε germline gene promoter and exhibits transrepressive activity Journal of Allergy and Clinical Immunology 126 2010 1016 1023
29. D. Galleguillos, A. Vecchiola, and J.A. Fuentealba PIASgamma represses the transcriptional activation induced by the nuclear receptor Nurr1 Journal of Biological Chemistry 279 2004 2005 2011 (Pubitemid 38084471)
30. H. Saitoh, and J. Hinchey Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3 Journal of Biological Chemistry 275 2000 6252 6258 (Pubitemid 30129915)
31. K. Park, P.M. Elias, and Y. Oda Regulation of cathelicidin antimicrobial peptide expression by an endoplasmic reticulum (ER) stress signaling, vitamin D receptor-independent pathway Journal of Biological Chemistry 286 2011 34121 34130