Deficiency of Glycine N-methyltransferase aggravates atherosclerosis in apolipoprotein E-null mice

Molecular Medicine

Volumn 18, Issue 5, 2012, Pages 744-752

  Chen, Chien Yu ^a   Ching, Li Chieh ^a   Liao, Yi Jen ^a   Yu, Yuan Bin ^b   Tsou, Chia Yuan ^a   Shyue, Song Kun ^c   Chen, Yi Ming Arthur ^a   Lee, Tzong Shyuan ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; APOLIPOPROTEIN E; CHOLESTEROL; GLYCINE METHYLTRANSFERASE; OXIDIZED LOW DENSITY LIPOPROTEIN; SCAVENGER RECEPTOR BI; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DISEASE EXACERBATION; DOWN REGULATION; GENE; GENE DELETION; GNMT GENE; HYPERLIPIDEMIA; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK FACTOR;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BIOLOGICAL TRANSPORT; CHOLESTEROL; GENE EXPRESSION; GLYCINE N-METHYLTRANSFERASE; HYPERLIPIDEMIAS; INFLAMMATION; LIPID METABOLISM; LIPOPROTEINS, LDL; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84864440092     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2011.00396     Document Type: Article

References (46)

1. Heady JE, Kerr SJ. (1973) Purification and characterization of glycine N-methyltransferase. J. Biol. Chem. 248:69-72.
2. Kerr SJ. (1972) Competing methyltransferase systems. J. Biol. Chem. 247:4248-52.
3. Cook RJ, Wagner C. (1984) Glycine N-methyltransferase is a folate binding protein of rat liver cytosol. Proc. Natl. Acad. Sci. U. S. A. 81:3631-4.
4. Bhat R, Bresnick E. (1997) Glycine N-methyltransferase is an example of functional diversity. Role as a polycyclic aromatic hydrocarbonbinding receptor. J. Biol. Chem. 272:21221-6.
5. Chen SY, et al. (2004) Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrenedetoxification pathway. Cancer Res. 64:3617-23.
6. Yen CH, et al. (2009) Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect. Toxicol. Appl. Pharmacol. 235:296-304.
7. Chen YM, et al. (1998) Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma. Int. J. Cancer. 75:787-93.
8. Avila MA, et al. (2000) Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma. J. Hepatol. 33:907-14.
9. Mudd SH, et al. (2001) Glycine N-methyltransferase deficiency: a novel inborn error causing persistent isolated hypermethioninaemia. J. Inherit. Metab. Dis. 24:448-64.
10. Augoustides-Savvopoulou P, et al. (2003) Glycine N-methyltransferase deficiency: a new patient with a novel mutation. J. Inherit. Metab. Dis. 26:745-59.
11. Liu SP, et al. (2007) Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver. Hepatology. 46:1413-25.
12. Martínez-Chantar ML, et al. (2008) Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology. 47:1191-9.
13. Liao YJ, et al. (2009) Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility. Int. J. Cancer. 124:816-26.
14. Glass CK, Witztum JL. (2001) Atherosclerosis: The road ahead. Cell. 104:503-16.
15. Lusis AJ. (2000) Atherosclerosis. Nature. 407:233-41.
16. Hansson GK, Libby P, Schönbeck U, Yan ZQ. (2002) Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ. Res. 91:281-91.
17. Kunjathoor VV, et al. (2002) Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J. Biol. Chem. 277:49982-8.
18. Rahaman SO, et al. (2006) A CD36-dependent signaling cascade is necessary for macrophage foam cell formation. Cell Metab. 4:211-21.
19. Witztum JL. (2005) You are right too! J. Clin. Invest. 115:2072-5.
20. Van Eck M, Bos IS, Hildebrand RB, Van Rij BT, Van Berkel TJ. (2004) Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development. Am. J. Pathol. 165:785-94.
21. Joyce CW, et al. (2002) The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice. Proc. Natl. Acad. Sci. U. S. A. 99:407-12.
22. Out R, et al. (2006) Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macro - phages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice. Arterioscler. Thromb. Vasc. Biol. 26:2295-300.
23. Kleemann R, Zadelaar S, Kooistra T. (2008). Cytokines and atherosclerosis: a comprehensive review of studies in mice. Cardiovasc. Res. 79:360-76.
24. Fazio S, Linton MF. (2001) The inflamed plaque: cytokine production and cellular cholesterol balance in the vessel wall. Am. J. Cardiol. 88:12-5E.
25. Li AC, Glass CK. (2002) The macrophage foam cell as a target for therapeutic intervention. Nat. Med. 8:1235-42.
26. Liu HH, et al. (2003) Characterization of reduced expression of glycine N-methyltransferase in cancerous hepatic tissues using two newly developed monoclonal antibodies. J. Biomed. Sci. 10:87-97.
27. Cheng LC, et al. (2011) α-Lipoic acid ameliorates foam cell formation via liver X receptor α-dependent upregulation of ATP-binding cassette transporters A1 and G1. Free Radic. Biol. Med. 50:47-54.
28. Han KH, et al. (2000) Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor gamma. J. Clin. Invest. 106:793-802.
29. Asztalos BF, et al. (2005) Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol efflux. J. Lipid Res. 46:2246-53.
30. Oram JF, Vaughan AM. (2006) ATP-Binding cassette cholesterol transporters and cardiovascular disease. Circ. Res. 99:1031-43.
31. Wittenburg H, Carey MC. (2002) Biliary cholesterol secretion by the twinned sterol halftransporters ABCG5 and ABCG8. J. Clin. Invest. 110:605-9.
32. Ciaccio M, Bellia C. (2010) Hyperhomocysteinemia and cardiovascular risk: effect of vitamin supplementation in risk reduction. Curr. Clin. Pharmacol. 5:30-6.
33. Varela-Rey M, et al. (2009) Impaired liver regeneration in mice lacking glycine N-methyltransferase. Hepatology. 50:443-52.
34. Rader DJ, Puré E. (2005) Lipoproteins, macrophage function, and atherosclerosis: beyond the foam cell? Cell Metab. 1:223-30.
35. Brooks-Wilson A, et al. (1999) Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat. Genet. 22:336-45.
36. Aiello RJ, et al. (2002) Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophages. Arterioscler. Thromb. Vasc. Biol. 22:630-7.
37. van Eck M, et al. (2002) Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. Proc. Natl. Acad. Sci. U. S. A. 99:6298-303.
38. Serfaty-Lacrosniere C, et al. (1994) Homozygous Tangier disease and cardiovascular disease. Atherosclerosis. 107:85-98.
39. Baranova I, et al. (2002) Lipopolysaccharide down regulates both scavenger receptor B1 and ATP binding cassette transporter A1 in RAW cells. Infect. Immun. 70:2995-3003.
40. McGillicuddy FC, et al. (2009) Inflammation impairs reverse cholesterol transport in vivo. Circulation. 119:1135-45.
41. Ramírez-Gómez F, Ortiz-Pineda PA, Rivera- Cardona G, García-Arrarás JE. (2009) LPSinduced genes in intestinal tissue of the sea cucumber Holothuria glaberrima. PLoS One. 4:e6178.
42. Ko K, et al. (2008) Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice. Lab. Invest. 88:1121-9.
43. Watson WH, Zhao Y, Chawla RK. (1999) S-adenosylmethionine attenuates the lipopoly - saccharide-induced expression of the gene for tumour necrosis factor alpha. Biochem. J. 342:21-5.
44. Liao YJ, et al. (2010) Deficiency of glycine N-methyltransferase results in deterioration of cellular defense to stress in mouse liver. Proteomics Clin. Appl. 4:394-406.
45. Yeo EJ, Wagner C. (1994) Tissue distribution of glycine N-methyltransferase, a major folatebinding protein of liver. Proc. Natl. Acad. Sci. U. S. A. 91:210-4.
46. Yuhanna IS, et al. (2001) High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase. Nat. Med. 7:853-7.