Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect

Toxicology and Applied Pharmacology

Volumn 235, Issue 3, 2009, Pages 296-304

  Yen, Chia Hung ^a,b   Hung, Jung Hsien ^b   Ueng, Yune Fang ^c   Liu, Shih Ping ^b,d   Chen, Shih Yin ^b   Liu, Hsiao Han ^b   Chou, Teh Ying ^e   Tsai, Ting Fen ^b   Darbha, Ramalakshmi ^f   Hsieh, Ling Ling ^g   Chen, Yi Ming Arthur ^b  

^a Georgetown Univ School of Medicine   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^f NATIONAL CANCER INSTITUTE   (United States)

^g CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

AFB1 metabolism; Detoxification; DNA adducts; Hepatocelluar carcinoma; Transgenic mouse model

Indexed keywords

AFLATOXIN B1; COMPLEMENTARY DNA; GLYCINE METHYLTRANSFERASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); S ADENOSYLMETHIONINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CANCER INHIBITION; CARCINOGENIC ACTIVITY; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DETOXIFICATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MALE; METABOLISM; MOUSE; NONHUMAN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

AFLATOXIN B1; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DNA ADDUCTS; FEMALE; GLYCINE N-METHYLTRANSFERASE; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, TRANSGENIC;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 61349189071     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.12.013     Document Type: Article

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