Variations in target gene expression and pathway profiles in the mouse hippocampus following treatment with different effective compounds for ischemia-reperfusion injury

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 385, Issue 8, 2012, Pages 797-806

  Chen, Yinying ^a   Zhou, Caixiu ^a   Yu, Yanan ^a   Liu, Jun ^a   Jing, Zhiwei ^a   Lv, Aiping ^a   Meng, Fanyun ^b   Wang, Zhong ^a   Wang, Yongyan ^a  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b BEIJING NORMAL UNIVERSITY   (China)

Author keywords

Cerebral ischemia; Gene function; KEGG; Signaling pathways

Indexed keywords

ABC TRANSPORTER; ANTIINFLAMMATORY AGENT; BAICALIN; CHINESE DRUG; CHOLIC ACID; CONCHA MARGARITIFERAUSTA; INTERLEUKIN 1; JASMINOIDIN; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL SHELL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; GENETIC DATABASE; GNB5 GENE; HIPPOCAMPUS; IL1RAP GENE; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHAM PROCEDURE; WDR38 GENE;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CAPILLARY ELECTROCHROMATOGRAPHY; CEREBRAL INFARCTION; CHOLIC ACID; DRUGS, CHINESE HERBAL; FLAVONOIDS; GENE EXPRESSION; HIPPOCAMPUS; IRIDOIDS; MALE; MICE; MICROARRAY ANALYSIS; MITOGEN-ACTIVATED PROTEIN KINASES; REAL-TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; RNA; SIGNAL TRANSDUCTION;

EID: 84864435405     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-012-0743-1     Document Type: Article

References (46)

1. Aye ILMH, Singh AT, Keelan JA (2009) Transport of lipids by ABC proteins : Interactions and implications for cellular toxicity, viability and function. Chem Biol Interact 3:327-339
2. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H (1986) Rat middle cerebral artery occlusion : Evaluation of the model and development of a neurologic examination. Stroke 17:472-476 (Pubitemid 16085691)
3. Benakis C, Bonny C, Hirt L (2010) JNK inhibition and inflammation after cerebral ischemia. Brain Behav Immun 5:800-811
4. Cai KF, Di Q, Shi JP, Zhang YD (2009) Dynamic changes of cell cycle elements in the ischemic brain after bone marrow stromal cells transplantation in rats. Neurosci Lett 467:15-19
5. Campagne MVL, Gill R (1998) Cell cycle-related gene expression in the adult rat brain : Selective induction of cyclin G1 and p21WAF1/ CIP1 in neurons following focal cerebral ischemia. Neuroscience 84:1097-1112 (Pubitemid 28157026)
6. Chomczynski P, Sacchi N (1987) The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1:156-159 (Pubitemid 17064313)
7. Covarrubias MY, Khan RL, Vadigepalli R, Hoek JB, Schwaber JS (2005) Chronic alcohol exposure alters transcription broadly in a key integrative brain nucleus for homeostasis : The nucleus tractus solitarius. Physiol Genomics 24:45-58
8. Denes A, Thornton P, Rothwell NJ, Allan SM (2010) Inflammation and brain injury : Acute cerebral ischaemia, peripheral and central inflammation. Brain Behav Immun 24:708-723
9. DiNapoli VA, Benkovic SA, Li X, Kelly KA, Miller DB, Rosen CL, Hube JD, O'Callaghan JP (2010) Age exaggerates proinflammatory cytokine signaling and truncates signal transducers and activators of transcription 3 signaling following ischemic stroke in the rat. Neuroscience 170:633-644
10. Doumont G, Martoriati A, Beekman C (2005) G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv. EMBO J 24:3093-3103 (Pubitemid 41486345)
11. Fujiki M, Abe E, Nagai Y, Shiqi K, Kubo T, Ishii K, Abe T, Kobayashi H (2010) Electroconvulsive seizure-induced VEGF is correlated with neuroprotective effects against cerebral infarction : Involvement of the phosphatidylinositol-3 kinase/Akt pathway. Exp Neurol 225:377-383
12. Hara H, Huang PL, Panahian N, Fishman MC, Moskowitz MA (1996) Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion. J Cereb Blood Flow Metab 16:605-611 (Pubitemid 26227069)
13. Harari OA, Liao JK (2010) NF-?B and innate immunity in ischemic stroke. Ann NY Acad Sci 1207:32-40
14. Harhausen D, Prinz V, Ziegler G, Gertz K, Enedres M, Lehrach H, Gasque P, Botto M, Stanhel PF, Dirnagl U, Nietfeld W, Trendelenburg G (2010) CD93/AA4.1 : A novel regulator of inflammation in murine focal cerebral ischemia. J Immunol 184:6407-6417
15. Hershko A (1997) Roles of ubiquitin-mediated proteolysis in cell cycle control. Curr Opin Cell Biol 9:788-799 (Pubitemid 27517267)
16. Himori N, Watanabe H, Akaike N, Kurasawa M, Itoh J, Tanaka Y (1990) Cerebral ischemia model with conscious mice : Involvement of NMDA receptor activation and derangement of learning and memory ability. J Pharmacol Methods 23:311-327 (Pubitemid 20203921)
17. Hollinger S, Hepler JR (2002) Cellular regulation of RGS proteins : Modulators and integrators of G protein signaling. Pharmacol Rev 54:527-559
18. Hopkins AL (2008) Network pharmacology : The next paradigm in drug discovery. Nat Chem Biol 4:682-690
19. Kanehisa M (1997) A database for post-genome analysis. Trends Genet 9:375-376 (Pubitemid 27376679)
20. Kanehisa M, Goto S (2000) KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28:27-30 (Pubitemid 30047706)
21. Kanehisa M, Goto S, Hattori M, Aoki-kinoshita KF, Itoh M, Kawashina S, Katayama T, Araki M, Hirakawa M (2006) From genomics to chemical genomics : New developments in KEGG. Nucleic Acids Res 34:D354-D357
22. Kastan MB, Canman CE, Leonard CJ (1995) P53, cell cycle control and apoptosis : Implications for cancer. Cancer Metastasis Rev 14:3-15
23. Lin TN, He YY,Wu G, Khan M, Hsu CY (1993) Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke 24:117-121 (Pubitemid 23014393)
24. Loddick SA, Rothwell NJ (1996) Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 16:932-940 (Pubitemid 26292060)
25. Maulik D, Ashraf QM, Mishra OP, Papadopoulos MD (2008) Activation of p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK) during hypoxia in cerebral cortical nuclei of guinea pig fetus at term : Role of nitric oxide. Neurosci Lett 439:94-99
26. Mehta SL, Manhas N, Raghubir R (2007) Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res Rev 54:34-66 (Pubitemid 46498164)
27. Meller R (2009) The role of the ubiquitin proteasome system in ischemia and ischemic tolerance. Neuroscientist 15:243-260
28. Mitsunori F, Eiko K, Koutaro I, Takashi I (2011) Large scale screening for novel rab effectors reveals unexpected broad rab binding specificity. Physiol Rev 91:119-149
29. Niizuma K, Yoshioka H, Chen H, Kim GS, Jung JE, Katsu M, Okami N, Chan PH (2010) Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia. Bba-Mol Basis Dis 1802:92-99
30. Nyitrai G, Puskás L, Antal K, Takács V, Sass M, Juhász G, Kardos J, Palkovits M (2005) Preconditioning-specific reduction of c-fos expression in hippocampal granule and pyramidal but not other forebrain neurons of ischemic brain : A quantitative immunohistochemical study. Neurosci Lett 3:344-349 (Pubitemid 40719184)
31. Piao CS, Che YZ, Han PL, Lee JK (2002) Delayed and differential induction of p38 MAPK isoforms in microglia and astrocytes in the brain after transient global ischemia. Mol Brain Res 2:137-144 (Pubitemid 35335531)
32. Rosette C, Karin M (1996) Ultraviolet light and osmotic stress : Activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 274:1194-1197 (Pubitemid 26389285)
33. Smith DE, Lipsky BP, Russell C, Ketchem RR, Kirchner J, Hensley K, Huang Y, Friedman WJ, Boissonneault V, Plante MM, Rivest S, Sims JE (2009) A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1. Immunity 30:817-831
34. Tang M, Villaescusa JC, Luo SX (2010) Interactions of Wnt/β-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons. J Neurosci 27:9280-9291
35. Waetzig V, Czeloth K, Hidding U (2005) C-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia. Glia 3:235-246 (Pubitemid 40769853)
36. White BC, Sullivan JM, DeGracia DJ, O'Neil BJ, Neumar RW, Grossman LI, Rafols JA, Krause GS (2000) Brain ischemia and reperfusion : Molecular mechanisms of neuronal injury. J Neurol Sci 1:1-33
37. Xie GX, Palmer PP (2007) How regulators of G protein signaling achieve selective regulation. J Mol Biol 366:349-365 (Pubitemid 46136207)
38. Xie K, Allen KL, Kourrich S, Colón-Saez J, Thomas MJ, Wickman K, Martemyanov KA (2010) Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling. Nat Neurosci 13:661-663
39. Yang YH, Dudoit S, Luu P, Lin DM, Peng V, Ngai J, Speed TP (2002) Normalization for cDNA microarray data : A robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res 30:e15
40. Zhang ZJ, Wang LY, Wang Z, Li PT, Wang YY (2006) Pharmacological evaluation of baicalin and jasminoidin and their combination on focal cerebral ischemia-reperfusion injury. China J Chin Mater Med 11:907-910
41. Zhang ZH, Xi GM, Li WC, Ling HY, Qu P, Fang XB (2010) Cyclic- AMP response element binding protein and tau are involved in the neuroprotective mechanisms of nerve growth factor during focal cerebral ischemia/reperfusion in rats. J Clin Neurosci 17:353-356
42. Zhao BS, Huo HR, Li LF (2007) Effect of Qingkailing on the expression of TOLL-like receptors and downstream signaling in macrophage RAW264.7. Chin Pharmacol Bull 8:1120
43. Zheng XR, Zhang SS, Yang YJ, Yin F, Wang X, Zhong L, Yu XH (2010) Adenoviral vector-mediated transduction of VEGF improves neural functional recovery after hypoxia-ischemic brain damage in neonatal rats. Brain Res Bull 81:372-377
44. Zhou CX (2010) The bioinformatics research of molecular pharmacological mechanisms of Qingkailing single component intervention on hippocampal cells of ischemic mice. doi: CNKI:CDMD:2.2010.180495
45. Zhou CX, Wang Z, Zhang ZJ, Jing ZW (2010a) The similarity and diversity analysis of Qingkailing effective components in regulating hippocampus ischemia-related genes of mice. Chin J Chin Mater Med 18:2475-2479
46. Zhou CX, Wang Z, Jing ZW, Zhang ZJ (2010b) Differences in pharmacological pathways among Qingkailing effective component. Chin Pharmacol Bull 4:547-551