Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 16, 2012, Pages 5169-5173

  Uno, Masaharu ^a   Koma, Yosuke ^a   Ban, Hyun Seung ^a   Nakamura, Hiroyuki ^a  

^a GAKUSHUIN UNIVERSITY   (Japan)

Author keywords

deSUMOylation; HIF 1; Non peptidic inhibitors; Selective inhibition; SENP1

Indexed keywords

1 [4 (N BENZYLAMINO)PHENYL] 3 PHENYLUREA DERIVATIVE; ANGIOGENESIS INHIBITOR; CARBANILAMIDE DERIVATIVE; GN 6767; GN 6860; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1ALPHA INHIBITOR; PROTEINASE INHIBITOR; SENP1 PROTEIN; STREPTAVIDIN; SUMO PROTEIN; TUBULIN; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; HYDROXYLATION; PROTEIN EXPRESSION; SUMOYLATION;

DRUG EVALUATION, PRECLINICAL; ENDOPEPTIDASES; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PHENYLUREA COMPOUNDS; PROTEASE INHIBITORS; PROTEIN BINDING; TUBULIN;

EID: 84864418026     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.06.084     Document Type: Article

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