Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 21, 2011, Pages 6389-6392

  Qiao, Zhitao ^a   Wang, Weiwei ^b   Wang, Lie ^a   Wen, Donghua ^b   Zhao, Yaxue ^a   Wang, Qing ^a   Meng, Qingqing ^a   Chen, Guoqiang ^b   Wu, Yingli ^b   Zhou, Huchen ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Benzodiazepine; Drug discovery; Inhibitor; Peptidomimetics; Structure activity relationship

Indexed keywords

BENZODIAZEPINE DERIVATIVE; PROTEIN INHIBITOR; SUMO PROTEIN; SUMO SPECIFIC PROTEASE 1 INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; IC 50; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION; SUMOYLATION;

EID: 80054780640     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.08.101     Document Type: Article

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