1-[4-(N-Benzylamino)phenyl]-3-phenylurea derivatives as a new class of hypoxia-inducible factor-1α inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 12, 2009, Pages 3166-3169

  Uno, Masaharu ^a   Ban, Hyun Seung ^a   Nakamura, Hiroyuki ^a  

^a GAKUSHUIN UNIVERSITY   (Japan)

Author keywords

1 4 (N Benzylamino)phenyl 3 phenylurea derivatives; Angiogenesis; Hypoxia; Hypoxia inducible factor (HIF) 1 inhibitor; VEGF

Indexed keywords

1 [4 (N BENZYLAMINO)PHENYL] 3 PHENYLUREA DERIVATIVE; CARBANILAMIDE DERIVATIVE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; CELL HYPOXIA; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS;

ANOXIA; CELL LINE; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INHIBITORY CONCENTRATION 50; PHENYLUREA COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 65749105442     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.122     Document Type: Article

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