Docking, synthesis and pharmacological activity of novel urea-derivatives designed as p38 MAPK inhibitors

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 264-271

  De Oliveira Lopes, Raquel ^a   Romeiro, Nelilma Correia ^a   De Lima, Cleverton Kleiton F ^a   Louback Da Silva, Leandro ^a   Palhares De Miranda, Ana Luisa ^a   Nascimento, Paulo Gustavo B D ^c   Cunha, Fernando Q ^b   Barreiro, Eliezer J ^a   Lima, Lídia Moreira ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF BRASILIA   (Brazil)

Author keywords

Analgesic; Anti inflammatory; Arthritis; Docking; p38 MAPK

Indexed keywords

ANTIRHEUMATIC AGENT; ETHYL 6 (3 CYCLOHEXYLUREIDO) 1,3 DIOXOLO 4,5 QUINOLINE 7 CARBOXYLATE; ETHYL 6 (3 PHENYLUREIDO) 1,3 DIOXOLO 4,5 QUINOLINE 7 CARBOXYLATE; ETHYL 6 [3 (4 BROMOPHENYL)UREIDO)] 1,3 DIOXOLO 4,5 QUINOLINE 7 CARBOXYLATE; ETHYL 6 [3 (4 CHLOROPHENYL)UREIDO] 1,3 DIOXOLO 4,5 QUINOLINE 7 CARBOXYLATE; ETHYL 6 [3 (4 NITROPHENYL)UREIDO] 1,3 DIOXOLO 4,5 QUINOLINE 7 CARBOXYLATE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; MALE; MOLECULAR DOCKING; MOUSE; NOCICEPTION; NONHUMAN; PAW EDEMA;

ANIMALS; CARRAGEENAN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; EDEMA; FEMALE; MALE; MICE; MOLECULAR DOCKING SIMULATION; NOCICEPTION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA; UREA;

EID: 84864412227     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.05.006     Document Type: Article

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