Discovery of a new antileishmanial hit in 8-nitroquinoline series

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 75-86

  Paloque, Lucie ^a   Verhaeghe, Pierre ^b   Casanova, Magali ^a   Castera Ducros, Caroline ^b   Dumètre, Aurélien ^a   Mbatchi, Litaty ^b   Hutter, Sébastien ^a   Kraiem M'Rabet, Manel ^b   Laget, Michèle ^a   Remusat, Vincent ^b   Rault, Sylvain ^c   Rathelot, Pascal ^b   Azas, Nadine ^a   Vanelle, Patrice ^b  

^a AIX MARSEILLE UNIVERSITY   (France)

^b AIX MARSEILLE UNIV   (France)

^c CENTRE D ETUDES ET DE RECHERCHE SUR LE MÉDICAMENT DE NORMANDIE   (France)

Author keywords

8 Nitroquinoline; Amastigotes; hepG2 cytotoxicity; Leishmania donovani; Leishmania infantum; Promastigotes; Selectivity index; Visceral leishmaniasis

Indexed keywords

8 NITROQUINOLIN 2 OL; AMPHOTERICIN B; ANTILEISHMANIAL AGENT; BETA GALACTOSIDASE; CHLOROQUINE; DOXORUBICIN; MILTEFOSINE; NITROQUINOLINE DERIVATIVE; PENTAMIDINE; PYRIMETHAMINE; QUINOLINE; UNCLASSIFIED DRUG;

AMASTIGOTE; ANIMAL CELL; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LEISHMANIA DONOVANI; NONHUMAN; PHARMACOPHORE; PROMASTIGOTE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIPROTOZOAL AGENTS; DRUG DISCOVERY; HEP G2 CELLS; HUMANS; LEISHMANIA DONOVANI; LIFE CYCLE STAGES; MICE; NITROQUINOLINES;

EID: 84864411113     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.04.029     Document Type: Article

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