Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 387-396

  Nammalwar, Baskar ^a   Bunce, Richard A ^a   Berlin, K Darrell ^a   Bourne, Christina R ^a   Bourne, Philip C ^a   Barrow, Esther W ^a   Barrow, William W ^a  

^a OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

2,4 Diaminopyrimidine; Antibiotic; DHFR inhibitor; Heck coupling; Sealed tube reaction

Indexed keywords

1 (1 BENZYL 2(1H) PHTHALAZINYL) 2 PROPEN 1 ONE; 1 (1 CYCLOHEXYL 2(1H) PHTHALAZINYL) 2 PROPEN 1 ONE; 1 (1 ISOBUTENYL 2(1H) PHTHALAZINYL) 2 PROPEN 1 ONE; 1 (1 ISOBUTYL 2(1H) PHTHALAZINYL) 2 PROPEN 1 ONE; 1 (1 ISOPROPYL 2(1H) PHTHALAZINYL) 2 PROPEN 1 ONE; 1 (1 PHENYL 2(1H) PHTHALAZINYL) 2 PROPEN 1 ONE; 1 [1 (1 ETHYLPROPYL) 2(1H) PHTHALAZINYL] 2 PROPEN 1 ONE; 1 [1 (2 METHYLPHENYL) 2(1H) PHTHALAZINYL] 2 PROPEN 1 ONE; 1 [1 (3 FLUOROPHENYL) 2(1H) PHTHALAZINYL] 2 PROPEN 1 ONE; 1 [1 (3,3,3 TRIFLUOROPROPYL) 2(1H) PHTHALAZINYL] 2 PROPEN 1 ONE; 1 [1 (3,5 DIMETHYLPHENYL) 2(1H) PHTHALAZINYL] 2 PROPEN 1 ONE; 1 [1 (4 FLUOROPHENYL) 2(1H) PHTHALAZINYL] 2 PROPEN 1 ONE; 1 [1 (4 METHOXYBENZYL) 2(1H) PHTHALAZINYL] 2 PROPEN 1 ONE; 1 [1 (4 METHYLBENZYL) 2(1H) PHTHALAZINYL] 2 PROPEN 1 ONE; 1 [1 (4 METHYLPHENYL) 2(1H) PHTHALAZINYL] 2 PROPEN 1 ONE; 1 [1 (4 TRIFLUOROMETHOXYBENZYL) 2(1H) PHTHALAZINYL] 2 PROPEN 1 ONE; 2,4 DIAMINO 5 (5 IODO 3,4 DIMETHOXYBENZYL)PYRIMIDINE; 2,4 DIAMINOPYRIMIDINE DERIVATIVE; 3 [5 [(2,4 DIAMINO 5 PYRIMIDINYL)METHYL] 2,3 DIMETHOXYPHENYL] 1 (1 CYCLOHEXYL 2(1H) PHTHALAZINYL) 2 PROPEN 1 ONE; 3 [5 [(2,4 DIAMINO 5 PYRIMIDINYL)METHYL] 2,3 DIMETHOXYPHENYL] 1 (1 ISOBUTENYL 2(1H) PHTHALAZINYL) 2 PROPEN 1 ONE; 3 [5 [(2,4 DIAMINO 5 PYRIMIDINYL)METHYL] 2,3 DIMETHOXYPHENYL] 1 (1 ISOBUTYL 2(1H) PHTHALAZINYL) 2 PROPEN 1 ONE; 3 [5 [(2,4 DIAMINO 5 PYRIMIDINYL)METHYL] 2,3 DIMETHOXYPHENYL] 1 (1 ISOPROPYL 2(1H) PHTHALAZINYL) 2 PROPEN 1 ONE; 3 [5 [(2,4 DIAMINO 5 PYRIMIDINYL)METHYL] 2,3 DIMETHOXYPHENYL] 1 (1 PHENYL 2(1H) PHTHALAZINYL) 2 PROPEN 1 ONE; 3 [5 [(2,4 DIAMINO 5 PYRIMIDINYL)METHYL] 2,3 DIMETHOXYPHENYL] 1 (1 PROPYL 2(1H) PHTHALAZINYL) 2 PROPEN 1 ONE; 3 [5 [(2,4 DIAMINO 5 PYRIMIDINYL)METHYL] 2,3 DIMETHOXYPHENYL] 1 [1 (1 ETHYLPROPYL) 2(1H) PHTHALAZINYL] 2 PROPEN 1 ONE; 3 [5 [(2,4 DIAMINO 5 PYRIMIDINYL)METHYL] 2,3 DIMETHOXYPHENYL] 1 [1 (3,3,3 TRIFLUOROPROPYL) 2(1H) PHTHALAZINYL] 2 PROPEN 1 ONE; 3 [5 [(2,4 DIAMINO 5 PYRIMIDINYL)METHYL] 2,3-DIMETHOXYPHENYL] 1 (1 PROPYL 2(1H) PHTHALAZINYL) 2 PROPEN 1 ONE; 3 MORPHOLINOPROPIONITRILE; 5 IODO 3,4 DIMETHOXYBENZALDEHYDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS ANTHRACIS; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN;

ANTI-BACTERIAL AGENTS; BACILLUS ANTHRACIS; CHEMISTRY TECHNIQUES, SYNTHETIC; FOLIC ACID ANTAGONISTS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PYRIMIDINES; STEREOISOMERISM; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 84864409038     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.05.018     Document Type: Article

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