Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5′-(-carboxyalkoxy)benzyl]pyrido[2,3- d]pyrimidine derivatives

Acta Crystallographica Section D: Biological Crystallography

Volumn 67, Issue 1, 2011, Pages 1-7

  Cody, Vivian ^a,b   Pace, Jim ^a  

^a HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

dihydrofolate reductase; inhibitors

Indexed keywords

DIHYDROFOLATE REDUCTASE; ENZYME INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; HUMAN; METABOLISM; PNEUMOCYSTIS CARINII; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; STRUCTURAL HOMOLOGY; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; NADP; PNEUMOCYSTIS CARINII; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRIDINES; PYRIMIDINES; STRUCTURAL HOMOLOGY, PROTEIN; TETRAHYDROFOLATE DEHYDROGENASE;

PNEUMOCYSTIS CARINII;

EID: 78651103069     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444910041004     Document Type: Article

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