Metabolism evaluation of the anticancer candidate AC04 by biomimetic oxidative model and rat liver microsomes

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4245-4251

  Pigatto, Maiara Cássia ^a   Alves De Lima, Maria Do Carmo ^b   Galdino, Suely Lins ^b   Pitta, Ivan Da Rocha ^b   Vessecchi, Ricardo ^c   Assis, Marilda Das Dores ^d   Santos, Joicy Santamalvina Dos ^d   Costa, Teresa Dalla ^a   Lopes, Norberto Peporine ^c  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^c Núcleo de Pesquisa em Produtos Naturais e Sintéticas NPPNS   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

AC04; Antitumor candidate; Liver microsomal metabolism; Oxidative metabolism

Indexed keywords

5 ACRIDIN 9 YLMETHYLENE 3 (4 METHYL BENZYL) THIAZOLIDINE 2,4 DIONE; AC 04; ACRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMIMETICS; CONTROLLED STUDY; DRUG ISOLATION; DRUG METABOLISM; DRUG SCREENING; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OXIDATION; PILOT STUDY; RAT; TANDEM MASS SPECTROMETRY;

ACRIDINES; ANIMALS; ANTINEOPLASTIC AGENTS; BIOMIMETICS; CHROMATOGRAPHY, THIN LAYER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICROSOMES, LIVER; OXIDATION-REDUCTION; PILOT PROJECTS; RATS; RATS, WISTAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; THIAZOLIDINEDIONES;

EID: 80052932657     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.06.029     Document Type: Article

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