The kinetic mechanism of S. pneumoniae DNA ligase and inhibition by adenosine-based antibacterial compounds

Biochemical Pharmacology

Volumn 84, Issue 5, 2012, Pages 654-660

  Jahić, Haris ^a   Liu, Ce Feng ^b   Thresher, Jason ^a   Livchak, Stephania ^a   Wang, Hongming ^a   Ehmann, David E ^a  

^a ASTRAZENECA   (United Kingdom)

^b BRANDEIS UNIVERSITY   (United States)

Author keywords

Antibiotics; DNA; Enzyme; Inhibition; Ligase

Indexed keywords

2 (BUTYLSULFANYL)ADENOSINE; 2 (CYCLOPENTYLOXY)ADENOSINE; ADENOSINE DERIVATIVE; ANTIINFECTIVE AGENT; MUTANT PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG BINDING; ENZYME INHIBITION; ENZYME METABOLISM; IC 50; INHIBITION KINETICS; ISOTHERMAL TITRATION CALORIMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

ADENOSINE; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; CALORIMETRY; DNA LIGASES; DNA PRIMERS; DRUG DISCOVERY; ENZYME INHIBITORS; KINETICS; MUTAGENESIS, SITE-DIRECTED; STREPTOCOCCUS PNEUMONIAE;

EID: 84864408546     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.06.017     Document Type: Article

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