Cyclosquaramides as Kinase Inhibitors with Anticancer Activity

ChemMedChem

Volumn 7, Issue 8, 2012, Pages 1472-1480

  Villalonga, Priam ^a   FernándezdeMattos, Silvia ^a   Ramis, Guillem ^a   Obrador Hevia, Antònia ^a   Sampedro, Angel ^a   Rotger, Carmen ^a   Costa, Antoni ^a  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

Author keywords

Antitumor agents; Biological activity; Inhibitors; Macrocycles; Squaramides

Indexed keywords

ABELSON KINASE; ANTINEOPLASTIC AGENT; BOC METHIONINE [2 (TERT BUTOXYCARBONYLAMINO) 4 METHYLSULFANYLBUTANOIC ACID]; CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE 7; CYCLIN DEPENDENT KINASE 9; FIBROBLAST GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; MACROCYCLIC COMPOUND; MACROCYCLIC CYCLOSQUARAMIDE DERIVATIVE; P21 ACTIVATED KINASE 4; P21 ACTIVATED KINASE 7; PACLITAXEL; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; POLO LIKE KINASE 1; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C GAMMA; PROTEIN KINASE ZAP 70; SCATTER FACTOR RECEPTOR; TERT BUTYL [3 (2 ((1 (TERT BUTOXYCARBONYL)AMINO) 4 (METHYLTHIO)BUTANAMIDO)PROPYL]CARBAMATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IC 50; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

AMIDES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MACROCYCLIC COMPOUNDS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES;

EID: 84864408244     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200157     Document Type: Article

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