Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 2. Selective and potent benzylamino cyclobutenediones

Journal of Medicinal Chemistry

Volumn 43, Issue 6, 2000, Pages 1203-1214

  Gilbert, Adam M ^a   Antane, Madelene M ^a   Argentieri, Thomas M ^a   Butera, John A ^a   Francisco, Gerardo D ^a   Freeden, Chris ^a   Gundersen, Eric G ^a   Graceffa, Russell F ^a   Herbst, David ^a   Hirth, Bradford H ^a   Lennox, Joseph R ^a   McFarlane, Geraldine ^a   Norton, N Wesley ^a   Quagliato, Dominick ^a   Sheldon, Jeffrey H ^a   Warga, Dawn ^a   Wojdan, Alexandra ^a   Woods, Morgan ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2,4 DICHLORO 6 METHYL BENZYLAMINO) 4 (1,1 DIMETHYLPROPYLAMINO)CYCLOBUT 3 ENE 1,2 DIONE; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; FEMALE; MALE; NONHUMAN; RAT; TISSUE SPECIFICITY; URGE INCONTINENCE; URINE INCONTINENCE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BENZYLAMINES; BLOOD PRESSURE; CYCLOBUTANES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FEMALE; HEART RATE; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; POTASSIUM CHANNELS; POTASSIUM CHLORIDE; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; URINARY BLADDER; URINARY INCONTINENCE;

EID: 17144468785     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9905108     Document Type: Article

References (12)

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