Evidence for mitoxantrone-induced block of inwardly rectifying K channels expressed in the osteoclast precursor RAW 264.7 cells differentiated with lipopolysaccharide

Cellular Physiology and Biochemistry

Volumn 30, Issue 3, 2012, Pages 687-701

  Wang, Chung Lin ^a,b   Tsai, Mei Ling ^b   Wu, Sheng Nan ^b  

^a Health Science and Management   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Membrane potential; Mitoxantrone; Osteoclast progenitor cells

Indexed keywords

BAFILOMYCIN A1; BARIUM CHLORIDE; CALCIUM; DOXORUBICIN; ESTRADIOL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; LIPOPOLYSACCHARIDE; MITOXANTRONE;

AMPLITUDE MODULATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONDUCTANCE; CONTROLLED STUDY; DRUG EFFECT; ELECTRODE; ELECTROPHYSIOLOGY; ENZYME INHIBITION; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; HYPERPOLARIZATION; IC 50; ION CURRENT; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; MOLECULAR MECHANICS; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING;

EID: 84864403868     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000341449     Document Type: Article

References (39)

1. Sims SM, Dixon SJ: Inwardly rectifying K+ current in osteoclasts. Am J Physiol 1989;256:C1277-1282.
2. Jongsma HJ, Wilders R: Channelopathies: Kir2.1 mutations jeopardize many cell functions. Curr Bio 2001;11R747-R750.
3. Komarova SV, Dixon SJ, Sims SM: Osteoclast ion channels: potential targets for antiresportive drugs. Curr Pharm Des 2001;7:637-654.
4. Lee I, Park C, Kang WK: Knockdown of inwardly rectifying potassium channel Kir2.2 suppresses tumorigenesis by inducing reactive oxygen-mediated cellular senescence. Mol Cancer Ther 2010;9:2951-2959.
5. Abraham R, Nagy T, Goss PE, Crump M: High dose chemotherapy and autologous blood stem cell support in women with breast carcinoma and isolated supraclavicular lymph node metastasis. Cancer 2000;88:790-795.
6. Eklund J, Kozloff M, Vlamakis J, Starr A, Mariott M, Gallot L, Jovanovic B, Schilder L, Robin E, Pins M, Bergan RC: Phase II study of mitoxantrone and ketoconazole for hormone-refractory prostate cancer. Cancer 2006;106:2459-2465.
7. Azim HA Jr, Mok T: Systemic nonhormonal management of advanced prostate cancer and its likely impact on patients survival and quality of life. Anticancer Drugs 2008;19:645-653.
8. Wang GX, Zhou XB, Eschenhagen T, Korth M: Effects of mitoxantrone on action potential and membrane currents in isolated cardiac myocytes. Br J Pharmacol 1999;127:321-330.
9. Tiligada E: Chemotherapy: induction of stress responses. Endoc Relat Cancer 2006;13:S115-S124.
10. Pan MH, Chang YH, Tsai ML, Lai CS, Ho SY, Badmae V, Ho CT: Pterostilbene suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophage. J Agric Food Chem 2008;56:7502-7509.
11. Wu SN, Wu PY, Tsai ML: Characterization of TRPM8-like channels activated by the cooling agent icilin in the macrophage cell line RAW 264.7. J Membr Biol 2011;241:11-20.
12. Islam S, Hassan F, Tumurkhuu G, Dagvadorj J, Koide N, Naiki Y, Mori I, Yoshida T, Yokochi T: Bacterial lipopolysaccharide induces osteoclast formation in RAW 264.7 macrophage cells. Biochem Biophys Res Commun 2007;360:346-351.
13. Akchurin T, Aissiou T, Kemeny N, Prosk E, Nigam N, Komarova SV: Complex dynamics of osteoclast formation and death in long-term cultures. PLoS ONE 2008;3:e2104.
14. Collin-Osdoby P, Osdoby P: RANKL-mediated osteoclast formation from murine RAW 264.7 cells. Methods Mol Biol 2012;816:187-202.
15. Boudot C, Saidak Z, Boulanouar AK, Petit L, Gouilleux F, Massy Z, Brazier M, Mentaverri R, Kamel S: Implication of the calcium sensing receptor and the phosphoinositide-3-kinase/Akt pathway in the extracellular calcium-mediated migration of RAW 264.7 osteoclast precursor cells. Bone 2010;46:1416-1423.
16. Okamoto F, Okabe K, Kajiya H: Genistein, a soybean isoflavone, inhibits inward rectifier K+ channels in rat osteoclasts. Jpn J Physiol 2001;51:501-509.
17. Espinosa L, Paret L, Ojeda C, Tourneur Y, Delmas PD, Chenu C: Osteoclast spreading kinetics are correlated with an oscillatory activation of a calcium-dependent potassium current. J Cell Sci 2002;115:3837-3848.
18. Newell EW, Schlichter LC: Integration of K+ and Cl-currents regulate steady-state and dynamic membrane potentials in cultured rat microglia. J Physiol 2005;567:869-890.
19. Sakai H, Kawawaki J, Moriura Y, Mori H, Morihata H, Kuno M: pH dependence and inhibition by extracellular calcium of proton currents via plasmalemmal vacuolar-type H+-ATPase in murine osteoclasts. J Physiol 2006;576:417-425.
20. Hammerland LG, Parihar AS, Nemeth EF, Sanguinetti MC: Voltage-activated potassium currents of rabbit osteoclasts: effects of extracellular calcium. Am J Physiol 1994;267:C1103-1111.
21. Park EJ, Kim SA, Choi YM, Kwon HK, Shim W, Lee G, Choi S: Capric acid inhibits NO production and STAT3 activation during LPS-induced osteoclastogenesis. PLOS One 2011;6:e27739.
22. Wu SN, Jan CR, Chiang HT: Fenamates stimulate BKCa channel activity in the human osteoblast-like MG-63 cells. J Invest Med 2001;49:522-533.
23. Ihaka R, Gentleman R: R: A language for data analysis and graphics. J Comp Graph Stat 1996;5:299-314.
24. Weidema AF, Dixon SJ, Sims SM: Electrophysiological characterization of ion channels in osteoclasts isolated from human decidual teeth. Bone 2000;27:5-11.
25. Sung RJ, Wu SN, Wu JS, Chang HD, Luo CH: Electrophysiological mechanisms of ventricular arrhythmias in relation to Andersen-Tawil syndrome under conditions of reduced IK1: a simulation study. Am J Physiol Heart Circ Physiol 2006;291:H2597-2605.
26. Liu TA, Chang HK, Shieh RC: Extracellular K+ elevates outward currents through Kir2.1 channels by increasing single-channel conductance. Biochem Biophys Acta 2011;1808:1772-1778.
27. Kitamura H, Yokoyama M, Akita H, Matsushita K, Kurachi Y, Yamada M: Tertiapin potently and selectively blocks muscarinic K+ channels in rabbit cardiac myocytes. J Pharmacol Exp Ther 2000;293:196-205.
28. Lee CM, Tannock IF: Inhibition of endosomal sequestration of basic anticancer drugs: influence on cytotoxicity and tissue penetration. Br J Cancer 2006;94:863-869.
29. Zoble C, Cho HC, Nguyen TT, Pekhletski R, Diaz RJ, Wilson GJ, Backx PH: Molecular dissection of the inward rectifier potassium current (7K1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2. J Physiol 2003;550:365-372.
30. Steward DJ, Green RM, Mikhael NZ, Montpetit V, Thibault M, Maroun JA: Human autopsy tissue concentrations of mitoxantrone. Cancer Treat Rep 1986;70:1255-1261.
31. Salerno M, Cenni E, Fotia C, Avnet S, Granchi D, Castelli F, Micieli D, Pignatello R, Capulli M, Rucci N, Angelucci A, Del Fattore A, Teti A, Zini N, Giunti A, Baldini N: Bone-targeted doxorubicin-loaded nanoparticles as a tool for the treatment of skeletal metastases. Curr Cancer Drug Targets 2010;10:649-659.
32. Ma Y, Yang Q, Wang L, Zhou X, Zhao Y, Deng Y: Repeated injections of PEGylated liposomal topotecan induces accelerated blood clearance phenomenon in rats. Eur J Pharm Sci 2011 2012;45:539-545.
33. Ma Y, Zhou L, Zheng H, Xing L, Li C, Cui J, Che S: pH-responsive mitoxantrone (MX) delivery using mesoporous silica nanoparticles (MSN). J Mater Chem 2011;21:9483-9486.
34. López-Izquierdo A, Ponce-Balbuena D, Moreno-Galindo EG, Aréchiga-Figueroa IA, Rodríguez-Martínez M, Ferrer T, Rodríguez-Menchaca AA, Sánchez-Chapula JA: The antimalarial drug mefloquine inhibits cardiac inward rectifier K+ channels: evidence for interference in PIP2-channel interaction. J Cardiovasc Pharmacol 2011;57:407-415.
35. Kobayashi T, Washiyama K, Ikeda K: Inhibition of G protein-activated inwardly rectifying K+ channels by different classes of antidepressants. PLoS One 2011;6:e28208.
36. Ho JW: Bisphosphonate stimulation of osteoblasts and osteoclastic metastasis as a mechanism of hypocalcaemia. Med Hypotheses 2012;78:377-379.
37. Matsuda H, Hayashi M, Okada M: Voltage-dependent block by internal spermine of the murine inwardly rectifying K+ channel, Kir2.1, with asymmetrical K+ concentrations. J Physiol 2010;588:4673-4681.
38. Huang MH, So EC, Liu YC, Wu SN: Glucocorticoids stimulate the activity of large-conductance Ca2+-activated K+ channels in pituitary GH3 and AtT-20 cells via a non-genomic mechanism. Steroids 2006;71:129-140.
39. Wang YJ, Lin MW, Wu SN, Sung RJ: The activation by estrogen receptor agonists of the BKCa-channel in human cardiac fibroblasts. Biochem Pharmacol 2007;73:1347-1357.