Fenamates stimulate BKCa channel activity in the human osteoblast-like MG-63 cells

Journal of Investigative Medicine

Volumn 49, Issue 6, 2001, Pages 522-533

  Wu, S N ^a   Jan, C R ^a   Chiang, H T ^a  

^a KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Ca2+ activated K+ current; Fenamates; Large conductance Ca2+ activated K+ channels; Nonsteroidal anti inflammatory drugs; Osteoblasts

Indexed keywords

ANTIINFLAMMATORY AGENT; FENAMIC ACID DERIVATIVE; FLUFENAMIC ACID; MECLOFENAMIC ACID; NIFLUMIC ACID; NIMESULIDE; POTASSIUM CHANNEL; TOLFENAMIC ACID; ANTI INFLAMMATORY AGENTS, NON STEROIDAL; CALCIUM CHANNELS, L TYPE; GLIBENCLAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNELS, CALCIUM ACTIVATED;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHANNEL GATING; HUMAN; HUMAN CELL; INFLAMMATION; OSTEOBLAST; PATCH CLAMP; PROSTAGLANDIN SYNTHESIS; CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM CHANNEL L TYPE; CELL CULTURE; CELL MEMBRANE POTENTIAL; DRUG EFFECT; METABOLISM;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALCIUM CHANNELS, L-TYPE; CELLS, CULTURED; GLYBURIDE; HUMAN; MECLOFENAMIC ACID; MEMBRANE POTENTIALS; NIFLUMIC ACID; OSTEOBLASTS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; SUPPORT, NON-U.S. GOV'T;

EID: 0035191086     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.2310/6650.2001.33629     Document Type: Article

References (38)

1. Flufenamic and tolfenamic acids and lemakalim relax guinea-pig isolated trachea by different mechanisms
2. Pharmacological control of human polymorphonuclear leukocyte degranulation by fenamates and inhibitors of receptor-mediated calcium entry and protein kinase C
3. Inhibition by fenamates of calcium influx and proliferation of human lymphocytes
4. Ca channels by niflumic, flufenamic and mefenamic acids
5. Comparison of the effects of fenamates on Ca-activated chloride and potassium currents in rabbit portal vein smooth muscle cells
6. Modulation of membrane currents and mechanical activity by niflumic acid in rat vascular smooth muscle
7. + channels by flufenamic acid
8. + channels in cells of embryonic chick osteoblast cultures
9. Voltage-activated ionic channels and conductances in embryonic chick osteoblast cultures
10. + channel in G292 osteoblast-like cells
11. Activation of maxi-K channels by parathyroid hormone and prostaglandin E2 in human osteoblast bone cells
12. Pharmacological and biochemical evidence for the regulation of osteocalcin secretion by potassium channels in human osteoblast-like MG-63 cells
13. Comparison of the effects of different anti-inflammatory drugs on synovial fluid prostanoid concentrations in patients with rheumatoid arthritis
14. Effect of tolfenamic acid on the metabolism of the main connective tissue components in rats
15. Effects of flunixin, tolfenamic acid, R(-) and S(+) ketoprofen on the response of equine synoviocytes to lipopolysaccharide stimulation
16. Tolfenamic acid and mefenamic acid in the treatment of primary dysmenorrhea
17. Tolfenamic acid: Clinical experience in rheumatic diseases
18. Analgesic-antipyretic and anti-inflammatory agents and drugs employed in the treatment of gout
19. Mechano- or acid stimulation: Two interactive modes of activation of the TREK-1 potassium channel
20. Direct regulation of ion channels by fatty acids
21. PKA and arachidonic acid activation of human recombinant CIC-2 chloride channels
22. 3 cells
23. Ca channels in rat pituitary tumor cells through lipoxygenase metabolites of arachidonic acid
24. 3 cells
25. Possible role of ion channels in the action of nonsteroidal anti-inflammatory drugs
26. + current in vascular endothelial cells
27. Osteocalcin secretion by the human osteosarcoma cell line MG-63
28. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
29. 3 cells
30. 2+ in rabbit isolated ear artery by platelet-derived growth factor
31. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons
32. + channels by Evans blue in cultured endothelial cells of human umbilical veins
33. + current by nordihydroguaiaretic acid in porcine coronary arterial smooth muscle cells
34. Niflumic acid-induced skeletal fluorosis: Iatrogenic disease or therapeutic perspective for osteoporosis?
35. Transplantable sites confer calcium sensitivity to BK channels
36. + channels
37. Effects of nonsteroidal antiinflammatory drugs on bone loss in chronic inflammatory disease
38. Cyclooxygenase-1 and cycloxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs