High-throughput interrogation of ligand binding mode using a fluorescence-based assay

Angewandte Chemie - International Edition

Volumn 51, Issue 31, 2012, Pages 7680-7683

  Śledź, Paweł ^a,b   Lang, Steffen ^a   Stubbs, Christopher J ^a   Abell, Chris ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

binding mode; drug discovery; ligand design; protein structures; structure activity relationships

Indexed keywords

BINDING MODES; DRUG DISCOVERY; LIGAND DESIGN; PROTEIN STRUCTURES; STRUCTURE ACTIVITY RELATIONSHIPS;

BINDING ENERGY; FLUORESCENCE;

LIGANDS;

LIGAND; PROTEIN;

ARTICLE; BINDING SITE; CALORIMETRY; CHEMICAL STRUCTURE; CHEMISTRY; FLUORESCENCE; GENETICS; HIGH THROUGHPUT SCREENING; MUTATION; STRUCTURE ACTIVITY RELATION; TEMPERATURE;

BINDING SITES; CALORIMETRY; FLUORESCENCE; HIGH-THROUGHPUT SCREENING ASSAYS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 84864400782     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201202660     Document Type: Article

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