Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 626-636

  Deslandes, Sébastien ^a   Lamoral Theys, Delphine ^b   Frongia, Céline ^c,d   Chassaing, Stefan ^a,c,d   Bruyère, Céline ^e   Lozach, Olivier ^f   Meijer, Laurent ^f,g   Ducommun, Bernard ^c,d,h   Kiss, Robert ^b   Delfourne, Evelyne ^a  

^a UPS)   (France)

^b Laboratoire de Chimie Analytique   (Belgium)

^c UNIVERSITÉ DE TOULOUSE   (France)

^d UPS   (France)

^e UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^f STATION BIOLOGIQUE   (France)

^g Centre de Perharidy   (France)

^h TOULOUSE UNIVERSITY HOSPITAL   (France)

Author keywords

G2 M checkpoint inhibitors; Granulatimide; Isogranulatimide; Marine alkaloid; Protein kinases; Pyrazolic analogs; Pyrrolic analogs; Quantitative videomicroscopy

Indexed keywords

11H 1,5,11,11B TETRAAZABENZO[A]TRINDENE 4,6 DIONE; 3H PYRAZOLO[4,3 A]PYRROLO[3,4 C]CARBAZOLE 4,6(5H,11H) DIONE; 5 (3 FLUOROPHENYL) N (3 PIPERIDINYL) 3 UREIDO 2 THIOPHENECARBOXAMIDE; 8 HYDROXY 11H 1,5,11,11B TETRAAZABENZO[A]TRINDENE 4,6 DIONE; 8 METHOXY 11H 1,5,11,11B TETRAAZABENZO[A]TRINDENE 4,6 DIONE; 8 METHOXY 3H PYRAZOLO[4,3 A]PYRROLO[3,4 C]CARBAZOLE 4,6(5H,11H) DIONE; 8 METHYL 11H 1,5,11,11B TETRAAZABENZO[A]TRINDENE 4,6 DIONE; 8 METHYL 11H 3A,5,11 TRIAZABENZO[A]TRINDENE 4,6 DIONE; 8 METHYL 3H PYRAZOLO[4,3 A]PYRROLO[3,4 C]CARBAZOLE 4,6(5H,11H) DIONE; ACETAMIDE DERIVATIVE; ALKALOID; CYTOSTATIC AGENT; DIBROMOMALEIMIDE; GLYOXYLIC ACID DERIVATIVE; GRANULATIMIDE; GRANULATIMIDE DERIVATIVE; INDOLE DERIVATIVE; ISOGRANULATIMIDE; ISOGRANULATIMIDE DERIVATIVE; MALEIMIDE; MALEIMIDE DERIVATIVE; PROTEIN SERINE THREONINE KINASE; PYRAZOLE; PYRROLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYCLIZATION; CYTOSTASIS; DRUG SYNTHESIS; ENZYME INHIBITION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; M PHASE CELL CYCLE CHECKPOINT; MOUSE; NONHUMAN; PHASE CONTRAST MICROSCOPY; PHOTOCHEMISTRY; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; TUMOR SUPPRESSOR GENE; VIDEO MICROSCOPY;

ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS; AQUATIC ORGANISMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY TECHNIQUES, SYNTHETIC; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; IMIDAZOLES; INDOLES; M PHASE CELL CYCLE CHECKPOINTS; MICE; PROTEIN KINASE INHIBITORS;

EID: 84864399435     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.06.012     Document Type: Article

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