Synthesis and biological activities of isogranulatimide analogues

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 17, 2007, Pages 5965-5980

  Hugon, Bernadette ^a   Anizon, Fabrice ^a   Bailly, Christian ^b   Golsteyn, Roy M ^c   Pierré, Alain ^c   Léonce, Stéphane ^c   Hickman, John ^c   Pfeiffer, Bruno ^c   Prudhomme, Michelle ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b CENTRE OSCAR LAMBRET   (France)

^c INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

Antitumor drugs; Chk1 inhibitors; Isogranulatimide; Pyrrolo 3,4 c carbazole

Indexed keywords

5 BROMO PYRROLO[3',4':5,6]INDOLIZINO[8,7 B]INDOLE 1,3 (2H,8H) DIONE; 5 CHLORO PYRROLO[3',4':5,6]INDOLIZINO[8,7 B]INDOLE 1,3 (2H,8H) DIONE; 7 HYDROXYSTAUROSPORINE; ANTINEOPLASTIC AGENT; CARBOHYDRATE DERIVATIVE; CASEIN KINASE I; CHECKPOINT KINASE 1; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN A; DNA TOPOISOMERASE; FIBROBLAST GROWTH FACTOR RECEPTOR 3; GLYCOGEN SYNTHASE KINASE 3; GRANULATIMIDE; HETEROCYCLIC COMPOUND; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; ISOGRANULATIMIDE A; ISOGRANULATIMIDE B; ISOGRANULATIMIDE C; ISOGRANULATIMIDE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE LCK; PYRROLE DERIVATIVE; REBECCAMYCIN; S6 KINASE; SB 218078; STAUROSPORINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; DNA CLEAVAGE; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

AZA COMPOUNDS; CARBAZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DNA TOPOISOMERASES, TYPE I; HUMANS; IMIDAZOLES; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PYRROLES; SRC-FAMILY KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

MURINAE;

EID: 34447283531     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.05.073     Document Type: Article

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