Human Papillomavirus Type 8 E6 Oncoprotein Inhibits Transcription of the PDZ Protein Syntenin-2

Journal of Virology

Volumn 86, Issue 15, 2012, Pages 7943-7952

  Lazić, Daliborka ^a   Hufbauer, Martin ^a   Zigrino, Paola ^a   Buchholz, Stephanie ^a   Kazem, Siamaque ^b   Feltkamp, Mariet C W ^b   Mauch, Cornelia ^a   Steger, Gertrud ^a   Pfister, Herbert ^a   Akgül, Baki ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN E6; SYNTENIN; SYNTENIN 2; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 20; HUMAN PAPILLOMAVIRUS TYPE 38; HUMAN PAPILLOMAVIRUS TYPE 5; HUMAN PAPILLOMAVIRUS TYPE 8; HUMAN TISSUE; MITOSIS INHIBITION; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TRANSCRIPTION TERMINATION; WART VIRUS;

AMINO ACID MOTIFS; BETAPAPILLOMAVIRUS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; EPIDERMIS; FEMALE; GENE EXPRESSION REGULATION; HUMAN PAPILLOMAVIRUS 16; HUMANS; MALE; ONCOGENE PROTEINS, VIRAL; REPRESSOR PROTEINS; SYNTENINS; TRANSCRIPTION, GENETIC;

BETAPAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS TYPE 8; HUMAN PAPILLOMAVIRUS TYPES;

EID: 84864391128     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00132-12     Document Type: Article

References (42)

1. Accardi R, et al. 2011. E6 and E7 from human papillomavirus type 16 cooperate to target the PDZ protein Na/H exchange regulatory factor 1. J. Virol. 85:8208-8216.
2. Akgül B, et al. 2011. Upregulation of lipocalin-2 in human papillomavirus-positive keratinocytes and cutaneous squamous cell carcinomas. J. Gen. Virol. 92:395-401.
3. Akgül B, et al. 2010. Human papillomavirus 5 and 8 E6 downregulate interleukin-8 secretion in primary human keratinocytes. J. Gen. Virol. 91:888-892.
4. Akgül B, Cooke JC, Storey A. 2006. HPV-associated skin disease. J. Pathol. 208:165-175.
5. Akgül B, et al. 2005. The E7 protein of cutaneous human papillomavirus type 8 causes invasion of human keratinocytes into the dermis in organotypic cultures of skin. Cancer Res. 65:2216-2223.
6. Akgül B, et al. 2007. HPV8 early genes modulate differentiation and cell cycle of primary human adult keratinocytes. Exp. Dermatol. 16:590-599.
7. Akgül B, Lemme W, Garcia-Escudero R, Storey A, Pfister HJ. 2005. UV-B irradiation stimulates the promoter activity of the high-risk, cutaneous human papillomavirus 5 and 8 in primary keratinocytes. Arch. Virol. 150:145-151.
8. Borrell-Pages M, et al. 2000. The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein. Mol. Biol. Cell 11:4217-4225.
9. Boxman IL, et al. 2001. Transduction of the E6 and E7 genes of epidermodysplasia-verruciformis-associated human papillomaviruses alters human keratinocyte growth and differentiation in organotypic cultures. J. Invest. Dermatol. 117:1397-1404.
10. Couchman JR. 2003. Syndecans: proteoglycan regulators of cell-surface microdomains? Nat. Rev. Mol. Cell Biol. 4:926-937.
11. Dell'Oste V, et al. 2009. High beta-HPV DNA loads and strong seroreactivity are present in epidermodysplasia verruciformis. J. Invest. Dermatol. 129:1026-1034.
12. Dickson MA, et al. 2000. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol. Cell. Biol. 20:1436-1447.
13. Feltkamp MC, de Koning MN, Bavinck JN, Ter Schegget J. 2008. Betapapillomaviruses: innocent bystanders or causes of skin cancer. J. Clin. Virol. 43:353-360.
14. Gallardo R, Ivarsson Y, Schymkowitz J, Rousseau F, Zimmermann P. 2010. Structural diversity of PDZ-lipid interactions. Chembiochem 11: 456-467.
15. Gewirtzman A, Bartlett B, Tyring S. 2008. Epidermodysplasia verruciformis and human papilloma virus. Curr. Opin. Infect. Dis. 21:141-146.
16. Giampieri S, Storey A. 2004. Repair of UV-induced thymine dimers is compromised in cells expressing the E6 protein from human papillomaviruses types 5 and 18. Br. J. Cancer 90:2203-2209.
17. Grootjans JJ, et al. 1997. Syntenin, a PDZ protein that binds syndecan cytoplasmic domains. Proc. Natl. Acad. Sci. U. S. A. 94:13683-13688.
18. Jackson S, Harwood C, Thomas M, Banks L, Storey A. 2000. Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins. Genes Dev. 14:3065-3073.
19. Kazem S, van der Meijden E, Struijk L, de Gruijl FR, Feltkamp MC. 2012. Human papillomavirus 8 E6 disrupts terminal skin differentiation and prevents pro-Caspase-14 cleavage. Virus Res. 163:609-616.
20. Koroll M, Rathjen FG, Volkmer H. 2001. The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity. J. Biol. Chem. 276:10646-10654.
21. Leverrier S, et al. 2007. Role of HPV E6 proteins in preventing UVBinduced release of pro-apoptotic factors from the mitochondria. Apoptosis 12:549-560.
22. Mantovani F, Banks L. 2001. The human papillomavirus E6 protein and its contribution to malignant progression. Oncogene 20:7874-7887.
23. Mortier E, et al. 2005. Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions. EMBO J. 24:2556-2565.
24. Muller-Schiffmann A, Beckmann J, Steger G. 2006. The E6 protein of the cutaneous human papillomavirus type 8 can stimulate the viral early and late promoters by distinct mechanisms. J. Virol. 80:8718-8728.
25. Münger K, Howley PM. 2002. Human papillomavirus immortalization and transformation functions. Virus Res. 89:213-228.
26. Niessen CM. 2007. Tight junctions/adherens junctions: basic structure and function. J. Invest. Dermatol. 127:2525-2532.
27. Orth G. 2006. Genetics of epidermodysplasia verruciformis: insights into host defense against papillomaviruses. Semin. Immunol. 18:362-374.
28. Pfeifer GP, Besaratinia A. 2012. UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer. Photochem. Photobiol. Sci. 11:90-97.
29. Pfister H. 2003. Chapter 8: Human papillomavirus and skin cancer. J. Natl. Cancer Inst. Monogr. 2003(31):52-56.
30. Pfister H, et al. 2003. High prevalence of epidermodysplasia verruciformis-associated human papillomavirus DNA in actinic keratoses of the immunocompetent population. Arch. Dermatol. Res. 295:273-279.
31. Rehtanz M, Schmidt HM, Warthorst U, Steger G. 2004. Direct interaction between nucleosome assembly protein 1 and the papillomavirus E2 proteins involved in activation of transcription. Mol. Cell. Biol. 24:2153-2168.
32. Rual JF, et al. 2005. Towards a proteome-scale map of the human protein-protein interaction network. Nature 437:1173-1178.
33. Struijk L, et al. 2008. Specific betapapillomaviruses associated with squamous cell carcinoma of the skin inhibit UVB-induced apoptosis of primary human keratinocytes. J. Gen. Virol. 89:2303-2314.
34. Thomas M, Dasgupta J, Zhang Y, Chen X, Banks L. 2008. Analysis of specificity determinants in the interactions of different HPV E6 proteins with their PDZ domain-containing substrates. Virology 376:371-378.
35. Tomlins C, Storey A. 2010. Cutaneous HPV5 E6 causes increased expression of Osteoprotegerin and Interleukin 6 which contribute to evasion of UV-induced apoptosis. Carcinogenesis 31:2155-2164.
36. Töpffer S, Muller-Schiffmann A, Matentzoglu K, Scheffner M, Steger G. 2007. Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses. J. Gen. Virol. 88:2956-2965.
37. Underbrink MP, Howie HL, Bedard KM, Koop JI, Galloway DA. 2008. E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation. J. Virol. 82:10408-10417.
38. Weissenborn SJ, et al. 2005. Human papillomavirus-DNA loads in actinic keratoses exceed those in non-melanoma skin cancers. J. Invest. Dermatol. 125:93-97.
39. Westphal K, Akgül B, Storey A, Nindl I. 2009. Cutaneous human papillomavirus E7 type-specific effects on differentiation and proliferation of organotypic skin cultures. Cell Oncol. 31:213-226.
40. Yugawa T, Kiyono T. 2009. Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins. Rev. Med. Virol. 19:97-113.
41. Zimmermann P, David G. 1999. The syndecans, tuners of transmembrane signaling. FASEB J. 13(Suppl):S91-S100.
42. zur Hausen H. 2002. Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer. 2:342-350.