Analysis of specificity determinants in the interactions of different HPV E6 proteins with their PDZ domain-containing substrates

Virology

Volumn 376, Issue 2, 2008, Pages 371-378

  Thomas, Miranda ^a   Dasgupta, Jhimli ^b   Zhang, Yi ^b   Chen, Xiaojiang ^b   Banks, Lawrence ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Dlg; Human papillomavirus E6; MAGI proteins; PDZ; Specificity; Structure

Indexed keywords

ARGININE; MEMBRANE PROTEIN; PDZ PROTEIN; PROTEIN E6; PROTEIN MAGI 1; PROTEIN MAGI 3; THREONINE; VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; ENZYME SPECIFICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; VIRUS TYPING; WART VIRUS;

AMINO ACID SEQUENCE; CELL ADHESION MOLECULES, NEURONAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRUS INFECTIONS; PDZ DOMAINS; PROTEIN BINDING; REPRESSOR PROTEINS; SEQUENCE ALIGNMENT;

HUMAN PAPILLOMAVIRUS; PAPILLOMAVIRIDAE;

EID: 44649114463     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2008.03.021     Document Type: Article

References (21)

1. Bilder D., Li M., and Perrimon N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289 (2000) 113-116
2. Doyle D.A., Lee A., Lewis J., Kim E., Sheng M., and MacKinnon R. Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell 85 (1996) 1067-1076
3. Gardiol D., Kuhne C., Glaunsinger B., Lee S.S., Javier R., and Banks L. Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation. Oncogene 18 (1999) 5487-5496
4. Glaunsinger B.A., Lee S.S., Thomas M., Banks L., and Javier R. Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins. Oncogene 19 (2000) 5270-5280
5. Grembecka J., Cierpicki T., Devedjiev Y., Derewenda U., Kang B.S., Bushweller J.H., and Derewenda Z.S. The binding of the PDZ tandem of syntenin to target proteins. Biochemistry 45 (2006) 3674-3683
6. Jackson S., Harwood C., Thomas M., Banks L., and Storey A. Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins. Genes Dev. 14 (2000) 3065-3073
7. Lagrange M., Charbonnier S., Orfanoudakis G., Robinson P., Zanier K., Masson M., Lutz Y., Travé G., Weiss E., and Deryckere F. Binding of human papillomavirus 16 E6 to p53 and E6AP is impaired by monoclonal antibodies directed against the second zinc-binding domain of E6. J. Gen. Virol. 86 (2005) 1001-1007
8. Latorre I.J., Roh M.H., Frese K.K., Weiss R.S., Margolis B., and Javier R.T. Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells. J. Cell Sci. 118 (2005) 4283-4293
9. Lee S.S., Glaunsinger B., Mantovani F., Banks L., and Javier R.T. Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins. J. Virol. 74 (2000) 9680-9693
10. Nakagawa S., and Huibregtse J.M. Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. Mol. Cell. Biol. 20 (2000) 8244-8253
11. Nominé Y., Masson M., Charbonnier S., Zanier K., Ristriani T., Deryckère F., Sibler A.P., Desplancq D., Atkinson R.A., Weiss E., Orfanoudakis G., Kieffer B., and Travé G. Structural and functional analysis of E6 oncoprotein: insights in the molecular pathways of human papillomavirus-mediated pathogenesis. Mol. Cell 21 (2006) 665-678
12. Pim D., Storey A., Thomas M., Massimi P., and Banks L. Mutational analysis of HPV-18 E6 identifies domains required for p53 degradation in vitro, abolition of p53 transactivation in vivo and immortalisation of primary BMK cells. Oncogene 9 (1994) 1869-1876
13. Pim D., Thomas M., and Banks L. Chimaeric HPV E6 proteins allow dissection of the proteolytic pathways regulating different E6 cellular target proteins. Oncogene 21 (2002) 8140-8148
14. Stiffler M.A., Chen J.R., Grantcharova V.P., Lei Y., Fuchs D., Allen J.E., Zaslavskaia L.A., and MacBeath G. PDZ domain binding selectivity is optimized across the mouse proteome. Science 317 (2007) 364-369
15. Storey A., Thomas M., Kalita A., Harwood C., Gardiol D., Mantovani F., Breuer J., Leigh I.M., Matlashewski G., and Banks L. Role of a p53 polymorphism in the development of human papillomavirus-associated cancer. Nature 393 (1998) 229-234
16. Thomas M., and Banks L. Human papillomavirus (HPV) E6 interactions with Bak are conserved amongst E6 proteins from high and low risk HPV types. J. Gen. Virol. 80 (1999) 1513-1517
17. Thomas M., Glaunsinger B., Pim D., Javier R., and Banks L. HPV E6 and MAGUK protein interactions: determination of the molecular basis for specific protein recognition and degradation. Oncogene 20 (2001) 5431-5439
18. Thomas M., Laura R., Hepner K., Guccione E., Sawyers C., Lasky L., and Banks L. Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation. Oncogene 21 (2002) 5088-5096
19. Thomas M., Massimi P., Navarro C., Borg J.P., and Banks L. The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins. Oncogene 24 (2005) 6222-6230
20. Wilken C., Kitzing K., Kurzbauer R., Ehrmann M., and Clausen T. Crystal structure of the DegS stress sensor: how a PDZ domain recognizes misfolded protein and activates a protease. Cell 117 (2004) 483-494
21. Zhang Y., Dasgupta J., Ma R.Z., Banks L., Thomas M., and Chen X.S. Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein. J. Virol. 81 (2007) 3618-3626