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Volumn 31, Issue 12, 2010, Pages 2155-2164

Cutaneous HPV5 E6 causes increased expression of osteoprotegerin and interleukin 6 which contribute to evasion of UV-induced apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; OSTEOPROTEGERIN; PROTEIN E6;

EID: 78649803918     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq200     Document Type: Article
Times cited : (19)

References (51)
  • 1
    • 41949086461 scopus 로고    scopus 로고
    • Cutaneous ultraviolet exposure and its relationship to the development of skin cancer
    • Rigel,D.S. (2008) Cutaneous ultraviolet exposure and its relationship to the development of skin cancer. J. Am. Acad. Dermatol., 58, S129-S132.
    • (2008) J. Am. Acad. Dermatol. , vol.58
    • Rigel, D.S.1
  • 2
    • 0346158419 scopus 로고    scopus 로고
    • Mechanisms involved in ultraviolet light-induced immunosuppression
    • Aubin,F. (2003) Mechanisms involved in ultraviolet light-induced immunosuppression. Eur. J. Dermatol., 13, 515-523.
    • (2003) Eur. J. Dermatol. , vol.13 , pp. 515-523
    • Aubin, F.1
  • 3
    • 41049090091 scopus 로고    scopus 로고
    • Early events in UV carcinogenesis-DNA damage, target cells and mutant p53 foci
    • de Gruijl,F.R. et al. (2008) Early events in UV carcinogenesis-DNA damage, target cells and mutant p53 foci. Photochem. Photobiol., 84, 382-387.
    • (2008) Photochem. Photobiol. , vol.84 , pp. 382-387
    • de Gruijl, F.R.1
  • 4
    • 0023640692 scopus 로고
    • The sunburn cell
    • Young,A.R. (1987) The sunburn cell. Photodermatol., 4, 127-134.
    • (1987) Photodermatol. , vol.4 , pp. 127-134
    • Young, A.R.1
  • 5
    • 73349091842 scopus 로고    scopus 로고
    • The role of mitochondria in apoptosis*
    • Wang,C. et al. (2009) The role of mitochondria in apoptosis*. Annu. Rev. Genet., 43, 95-118.
    • (2009) Annu. Rev. Genet. , vol.43 , pp. 95-118
    • Wang, C.1
  • 6
    • 61649096651 scopus 로고    scopus 로고
    • Starting and propagating apoptotic signals in UVB irradiated keratinocytes
    • Van Laethem,A. et al. (2009) Starting and propagating apoptotic signals in UVB irradiated keratinocytes. Photochem. Photobiol. Sci., 8, 299-308.
    • (2009) Photochem. Photobiol. Sci. , vol.8 , pp. 299-308
    • Van Laethem, A.1
  • 7
    • 31144451594 scopus 로고    scopus 로고
    • HPV-associated skin disease
    • Akgul,B. et al. (2006) HPV-associated skin disease. J. Pathol., 208, 165-175.
    • (2006) J. Pathol. , vol.208 , pp. 165-175
    • Akgul, B.1
  • 8
    • 0028863579 scopus 로고
    • Epidermodysplasia verruciformis as a model of human papillomavirus-induced genetic cancer of the skin
    • Majewski,S. et al. (1995) Epidermodysplasia verruciformis as a model of human papillomavirus-induced genetic cancer of the skin. Arch. Dermatol., 131, 1312-1318.
    • (1995) Arch. Dermatol. , vol.131 , pp. 1312-1318
    • Majewski, S.1
  • 9
    • 1942443952 scopus 로고    scopus 로고
    • Human papillomaviruses in transplant-associated skin cancers
    • Stockfleth,E. et al. (2004) Human papillomaviruses in transplant-associated skin cancers. Dermatol. Surg., 30, 604-609.
    • (2004) Dermatol. Surg. , vol.30 , pp. 604-609
    • Stockfleth, E.1
  • 10
    • 22144457077 scopus 로고    scopus 로고
    • Human papillomavirus gene expression in cutaneous squamous cell carcinomas from immunosuppressed and immunocompetent individuals
    • Purdie,K.J. et al. (2005) Human papillomavirus gene expression in cutaneous squamous cell carcinomas from immunosuppressed and immunocompetent individuals. J. Invest. Dermatol., 125, 98-107.
    • (2005) J. Invest. Dermatol. , vol.125 , pp. 98-107
    • Purdie, K.J.1
  • 11
    • 33644943412 scopus 로고    scopus 로고
    • Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin
    • Karagas,M.R. et al. (2006) Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin. J. Natl Cancer Inst., 98, 389-395.
    • (2006) J. Natl Cancer Inst. , vol.98 , pp. 389-395
    • Karagas, M.R.1
  • 12
    • 22144462481 scopus 로고    scopus 로고
    • Human papillomavirus-DNA loads in actinic keratoses exceed those in non-melanoma skin cancers
    • Weissenborn,S.J. et al. (2005) Human papillomavirus-DNA loads in actinic keratoses exceed those in non-melanoma skin cancers. J. Invest. Dermatol., 125, 93-97.
    • (2005) J. Invest. Dermatol. , vol.125 , pp. 93-97
    • Weissenborn, S.J.1
  • 13
    • 0037813131 scopus 로고    scopus 로고
    • Prevalence and type spectrum of human papillomaviruses in healthy skin samples collected in three continents
    • Antonsson,A. et al. (2003) Prevalence and type spectrum of human papillomaviruses in healthy skin samples collected in three continents. J. Gen. Virol., 84, 1881-1886.
    • (2003) J. Gen. Virol. , vol.84 , pp. 1881-1886
    • Antonsson, A.1
  • 14
    • 34248225972 scopus 로고    scopus 로고
    • Betapapillomaviruses frequently persist in the skin of healthy individuals
    • de Koning,M.N. et al. (2007) Betapapillomaviruses frequently persist in the skin of healthy individuals. J. Gen. Virol., 88, 1489-1495.
    • (2007) J. Gen. Virol. , vol.88 , pp. 1489-1495
    • de Koning, M.N.1
  • 15
    • 33645211201 scopus 로고    scopus 로고
    • Human papillomavir1uses: basic mechanisms of pathogenesis and oncogenicity
    • Hebner,C.M. et al. (2006) Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity. Rev. Med. Virol., 16, 83-97.
    • (2006) Rev. Med. Virol. , vol.16 , pp. 83-97
    • Hebner, C.M.1
  • 16
    • 4143124369 scopus 로고    scopus 로고
    • Human papillomavirus type 77 E6 protein selectively inhibits p53-dependent transcription of proapoptotic genes following UV-B irradiation
    • Giampieri,S. et al. (2004) Human papillomavirus type 77 E6 protein selectively inhibits p53-dependent transcription of proapoptotic genes following UV-B irradiation. Oncogene, 23, 5864-5870.
    • (2004) Oncogene , vol.23 , pp. 5864-5870
    • Giampieri, S.1
  • 17
    • 0034719466 scopus 로고    scopus 로고
    • E6 proteins from diverse cutaneous HPV types inhibit apoptosis in response to UV damage
    • Jackson,S. et al. (2000) E6 proteins from diverse cutaneous HPV types inhibit apoptosis in response to UV damage. Oncogene, 19, 592-598.
    • (2000) Oncogene , vol.19 , pp. 592-598
    • Jackson, S.1
  • 18
    • 52649180182 scopus 로고    scopus 로고
    • Specific betapapillomaviruses associated with squamous cell carcinoma of the skin inhibit UVB-induced apoptosis of primary human keratinocytes
    • Struijk,L. et al. (2008) Specific betapapillomaviruses associated with squamous cell carcinoma of the skin inhibit UVB-induced apoptosis of primary human keratinocytes. J. Gen. Virol., 89, 2303-2314.
    • (2008) J. Gen. Virol. , vol.89 , pp. 2303-2314
    • Struijk, L.1
  • 19
    • 0033637306 scopus 로고    scopus 로고
    • Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins
    • Jackson,S. et al. (2000) Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins. Genes Dev., 14, 3065-3073.
    • (2000) Genes Dev. , vol.14 , pp. 3065-3073
    • Jackson, S.1
  • 20
    • 33847262957 scopus 로고    scopus 로고
    • Role of HPV E6 proteins in preventing UVB-induced release of pro-apoptotic factors from the mitochondria
    • Leverrier,S. et al. (2007) Role of HPV E6 proteins in preventing UVB-induced release of pro-apoptotic factors from the mitochondria. Apoptosis, 12, 549-560.
    • (2007) Apoptosis , vol.12 , pp. 549-560
    • Leverrier, S.1
  • 21
    • 55249122277 scopus 로고    scopus 로고
    • E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation
    • Underbrink,M.P. et al. (2008) E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation. J. Virol., 82, 10408-10417.
    • (2008) J. Virol. , vol.82 , pp. 10408-10417
    • Underbrink, M.P.1
  • 22
    • 3042821260 scopus 로고    scopus 로고
    • Repair of UV-induced thymine dimers is compromised in cells expressing the E6 protein from human papillomaviruses types 5 and 18
    • Giampieri,S. et al. (2004) Repair of UV-induced thymine dimers is compromised in cells expressing the E6 protein from human papillomaviruses types 5 and 18. Br. J. Cancer, 90, 2203-2209.
    • (2004) Br. J. Cancer , vol.90 , pp. 2203-2209
    • Giampieri, S.1
  • 23
    • 33745016476 scopus 로고    scopus 로고
    • E6/E7 expression of human papillomavirus types in cutaneous squamous cell dysplasia and carcinoma in immunosuppressed organ transplant recipients
    • Dang,C. et al. (2006) E6/E7 expression of human papillomavirus types in cutaneous squamous cell dysplasia and carcinoma in immunosuppressed organ transplant recipients. Br. J. Dermatol., 155, 129-136.
    • (2006) Br. J. Dermatol. , vol.155 , pp. 129-136
    • Dang, C.1
  • 24
    • 0037194353 scopus 로고    scopus 로고
    • Reduced apoptotic levels in squamous but not basal cell carcinomas correlates with detection of cutaneous human papillomavirus
    • Jackson,S. et al. (2002) Reduced apoptotic levels in squamous but not basal cell carcinomas correlates with detection of cutaneous human papillomavirus. Br. J. Cancer, 87, 319-323.
    • (2002) Br. J. Cancer , vol.87 , pp. 319-323
    • Jackson, S.1
  • 25
    • 0016729431 scopus 로고
    • Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells
    • Rheinwald,J.G. et al. (1975) Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell, 6, 331-343.
    • (1975) Cell , vol.6 , pp. 331-343
    • Rheinwald, J.G.1
  • 26
    • 16844368716 scopus 로고    scopus 로고
    • The E7 protein of cutaneous human papillomavirus type 8 causes invasion of human keratinocytes into the dermis in organotypic cultures of skin
    • Akgul,B. et al. (2005) The E7 protein of cutaneous human papillomavirus type 8 causes invasion of human keratinocytes into the dermis in organotypic cultures of skin. Cancer Res., 65, 2216-2223.
    • (2005) Cancer Res. , vol.65 , pp. 2216-2223
    • Akgul, B.1
  • 27
    • 0033535347 scopus 로고    scopus 로고
    • Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis
    • Griffiths,G.J. et al. (1999) Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis. J. Cell Biol., 144, 903-914.
    • (1999) J. Cell Biol. , vol.144 , pp. 903-914
    • Griffiths, G.J.1
  • 28
    • 0036699925 scopus 로고    scopus 로고
    • Expression of the bcl-2 family of pro- and antiapoptotic genes in multiple myeloma and normal plasma cells: regulation during interleukin-6(IL-6)-induced growth and survival
    • Spets,H. et al. (2002) Expression of the bcl-2 family of pro- and antiapoptotic genes in multiple myeloma and normal plasma cells: regulation during interleukin-6(IL-6)-induced growth and survival. Eur. J. Haematol., 69, 76-89.
    • (2002) Eur. J. Haematol. , vol.69 , pp. 76-89
    • Spets, H.1
  • 29
    • 4043138669 scopus 로고    scopus 로고
    • Osteoprotegerin (OPG) produced by bone marrow stromal cells protects breast cancer cells from TRAIL-induced apoptosis
    • Neville-Webbe,H.L. et al. (2004) Osteoprotegerin (OPG) produced by bone marrow stromal cells protects breast cancer cells from TRAIL-induced apoptosis. Breast Cancer Res. Treat., 86, 269-279.
    • (2004) Breast Cancer Res. Treat. , vol.86 , pp. 269-279
    • Neville-Webbe, H.L.1
  • 30
    • 33748655012 scopus 로고    scopus 로고
    • The E6 protein of the cutaneous human papillomavirus type 8 can stimulate the viral early and late promoters by distinct mechanisms
    • Muller-Schiffmann,A. et al. (2006) The E6 protein of the cutaneous human papillomavirus type 8 can stimulate the viral early and late promoters by distinct mechanisms. J. Virol., 80, 8718-8728.
    • (2006) J. Virol. , vol.80 , pp. 8718-8728
    • Muller-Schiffmann, A.1
  • 31
    • 0031029911 scopus 로고    scopus 로고
    • Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells
    • Chauhan,D. et al. (1997) Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells. Blood, 89, 227-234.
    • (1997) Blood , vol.89 , pp. 227-234
    • Chauhan, D.1
  • 32
    • 46049108371 scopus 로고    scopus 로고
    • Osteoprotegerin decreases human osteoclast apoptosis by inhibiting the TRAIL pathway
    • Chamoux,E. et al. (2008) Osteoprotegerin decreases human osteoclast apoptosis by inhibiting the TRAIL pathway. J. Cell. Physiol., 216, 536-542.
    • (2008) J. Cell. Physiol. , vol.216 , pp. 536-542
    • Chamoux, E.1
  • 33
    • 63049093672 scopus 로고    scopus 로고
    • Role of full-length osteoprotegerin in tumor cell biology
    • Zauli,G. et al. (2009) Role of full-length osteoprotegerin in tumor cell biology. Cell. Mol. Life Sci., 66, 841-851.
    • (2009) Cell. Mol. Life Sci. , vol.66 , pp. 841-851
    • Zauli, G.1
  • 34
    • 0347624706 scopus 로고    scopus 로고
    • Tumor necrosis factor related apoptosis inducing ligand triggers apoptosis in dividing but not in differentiating human epidermal keratinocytes
    • Jansen,B.J. et al. (2003) Tumor necrosis factor related apoptosis inducing ligand triggers apoptosis in dividing but not in differentiating human epidermal keratinocytes. J. Invest. Dermatol., 121, 1433-1439.
    • (2003) J. Invest. Dermatol. , vol.121 , pp. 1433-1439
    • Jansen, B.J.1
  • 35
    • 27544476971 scopus 로고    scopus 로고
    • The role of IL-6 and STAT3 in inflammation and cancer
    • Hodge,D.R. et al. (2005) The role of IL-6 and STAT3 in inflammation and cancer. Eur. J. Cancer, 41, 2502-2512.
    • (2005) Eur. J. Cancer , vol.41 , pp. 2502-2512
    • Hodge, D.R.1
  • 36
    • 34247849312 scopus 로고    scopus 로고
    • The antiapoptotic effect of IL-6 autocrine loop in a cellular model of advanced prostate cancer is mediated by Mcl-1
    • Cavarretta,I.T. et al. (2007) The antiapoptotic effect of IL-6 autocrine loop in a cellular model of advanced prostate cancer is mediated by Mcl-1. Oncogene, 26, 2822-2832.
    • (2007) Oncogene , vol.26 , pp. 2822-2832
    • Cavarretta, I.T.1
  • 37
    • 70349117324 scopus 로고    scopus 로고
    • IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins
    • Waxman,A.B. et al. (2009) IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins. Am. J. Respir. Cell Mol. Biol., 41, 385-396.
    • (2009) Am. J. Respir. Cell Mol. Biol. , vol.41 , pp. 385-396
    • Waxman, A.B.1
  • 38
    • 27844470581 scopus 로고    scopus 로고
    • Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks
    • Garinis,G.A. et al. (2005) Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks. EMBO J., 24, 3952-3962.
    • (2005) EMBO J. , vol.24 , pp. 3952-3962
    • Garinis, G.A.1
  • 39
    • 0032555716 scopus 로고    scopus 로고
    • Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
    • Luo,X. et al. (1998) Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell, 94, 481-490.
    • (1998) Cell , vol.94 , pp. 481-490
    • Luo, X.1
  • 40
    • 33751398479 scopus 로고    scopus 로고
    • Modulation of apoptosis by human papillomavirus (HPV) oncoproteins
    • Garnett,T.O. et al. (2006) Modulation of apoptosis by human papillomavirus (HPV) oncoproteins. Arch. Virol., 151, 2321-2335.
    • (2006) Arch. Virol. , vol.151 , pp. 2321-2335
    • Garnett, T.O.1
  • 41
    • 32444433449 scopus 로고    scopus 로고
    • Pathways involved in sunburn cell formation: deregulation in skin cancer
    • Claerhout,S. et al. (2006) Pathways involved in sunburn cell formation: deregulation in skin cancer. Photochem. Photobiol. Sci., 5, 199-207.
    • (2006) Photochem. Photobiol. Sci. , vol.5 , pp. 199-207
    • Claerhout, S.1
  • 42
    • 11144224085 scopus 로고    scopus 로고
    • cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-in-ducing signaling complex in human keratinocytes
    • Wachter,T. et al. (2004) cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-in-ducing signaling complex in human keratinocytes. J. Biol. Chem., 279, 52824-52834.
    • (2004) J. Biol. Chem. , vol.279 , pp. 52824-52834
    • Wachter, T.1
  • 43
    • 1842506467 scopus 로고    scopus 로고
    • The HPV-16 E5 protein inhibits TRAIL- and FasL-mediated apoptosis in human keratinocyte raft cultures
    • Kabsch,K. et al. (2004) The HPV-16 E5 protein inhibits TRAIL- and FasL-mediated apoptosis in human keratinocyte raft cultures. Intervirology, 47, 48-56.
    • (2004) Intervirology , vol.47 , pp. 48-56
    • Kabsch, K.1
  • 44
    • 33749617478 scopus 로고    scopus 로고
    • Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis
    • Garnett,T.O. et al. (2006) Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis. Cell Death Differ., 13, 1915-1926.
    • (2006) Cell Death Differ. , vol.13 , pp. 1915-1926
    • Garnett, T.O.1
  • 45
    • 33846781716 scopus 로고    scopus 로고
    • Alpha- and betapapillomavirus E6/E7 genes differentially modulate pro-inflammatory gene expression
    • De Andrea,M. et al. (2007) Alpha- and betapapillomavirus E6/E7 genes differentially modulate pro-inflammatory gene expression. Virus Res., 124, 220-225.
    • (2007) Virus Res. , vol.124 , pp. 220-225
    • De Andrea, M.1
  • 46
    • 68249096784 scopus 로고    scopus 로고
    • Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
    • Rodier,F. et al. (2009) Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat. Cell Biol., 11, 973-979.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 973-979
    • Rodier, F.1
  • 47
    • 3042635767 scopus 로고    scopus 로고
    • The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis
    • Wang,X.P. et al. (2004) The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis. J. Invest. Dermatol., 123, 124-131.
    • (2004) J. Invest. Dermatol. , vol.123 , pp. 124-131
    • Wang, X.P.1
  • 48
    • 78649789584 scopus 로고    scopus 로고
    • IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines
    • [Epub ahead of print] doi:10.1002/ijc.25621
    • Lederle,W. et al. IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines. Int. J. Cancer [Epub ahead of print]. doi:10.1002/ijc.25621.
    • Int. J. Cancer
    • Lederle, W.1
  • 49
    • 77949537757 scopus 로고    scopus 로고
    • Human papillomavirus 5 and 8 E6 downregulate interleukin-8 secretion in primary human keratinocytes
    • Akgul,B. et al. (2009) Human papillomavirus 5 and 8 E6 downregulate interleukin-8 secretion in primary human keratinocytes. J. Gen. Virol, 91, 888-892.
    • (2009) J. Gen. Virol. , vol.91 , pp. 888-892
    • Akgul, B.1
  • 50
    • 76049097477 scopus 로고    scopus 로고
    • HCV-related hepatocellular carcinoma: from chronic inflammation to cancer
    • Castello,G. et al. (2009) HCV-related hepatocellular carcinoma: from chronic inflammation to cancer. Clin. Immunol, 134, 237-250.
    • (2009) Clin. Immunol. , vol.134 , pp. 237-250
    • Castello, G.1
  • 51
    • 59349104441 scopus 로고    scopus 로고
    • Papillomavirus E6 proteins
    • Howie,H.L. et al. (2009) Papillomavirus E6 proteins. Virology, 384, 324-334.
    • (2009) Virology , vol.384 , pp. 324-334
    • Howie, H.L.1


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