The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions

American Journal of Physiology - Endocrinology and Metabolism

Volumn 292, Issue 3, 2007, Pages

  Pedersen, Kim B ^a   Zhang, Pili ^a,e   Doumen, Chris ^b,f   Charbonnet, Marcel ^a,e   Lu, Danhong ^c   Newgard, Christopher B ^c   Haycock, John W ^a,g   Lange, Alex J ^d   Scott, Donald K ^a,e  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b XAVIER UNIVERSITY OF LOUISIANA   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^f Department of Geology and Environmental Science   (United States)

^g PhosphoSolutions   (United States)

Author keywords

Adenosine 3 ,5 cyclic monophosphate response element; Carbohydrate response element; Carbohydrate response element binding protein; Glucose 6 phosphatase; Promoter

Indexed keywords

GLUCOKINASE; GLUCOSE 6 PHOSPHATASE; HEPATOCYTE NUCLEAR FACTOR 1;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BINDING SITE; CATALYSIS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GLUCOSE HOMEOSTASIS; HEPATOMA CELL; LIVER CELL; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; REGULATORY SEQUENCE;

ANIMALS; BASE SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE, TUMOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENES, REPORTER; GLUCOSE; GLUCOSE-6-PHOSPHATASE; HEPATOCYTE NUCLEAR FACTOR 1; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); RATS; RESPONSE ELEMENTS; TRANSFECTION;

EID: 33947151464     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00510.2006     Document Type: Article

References (54)

1. Ahn S, Olive M, Aggarwal S, Krylov D, Ginty DD, Vinson C. A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos. Mol Cell Biol 18: 967-977, 1998.
2. Aiston S, Trinh KY, Lange AJ, Newgard CB, Agius L. Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase. J Biol Chem 274: 24559-24566, 1999.
3. Allgood VE, Zhang Y, O'Malley BW, Weigel NL. Analysis of chicken progesterone receptor function and phosphorylation using an adenovirus-mediated procedure for high-efficiency DNA transfer. Biochemistry 36: 224-232, 1997.
4. Andreone TL, Printz RL, Pilkis SJ, Magnuson MA, Granner DK. The amino acid sequence of rat liver glucokinase deduced from cloned cDNA. J Biol Chem 264: 363-369, 1989.
5. Argaud D, Kirby TL, Newgard CB, Lange AJ. Stimulation of glucose-6-phosphatase gene expression by glucose and fructose-2,6-bisphosphate. J Biol Chem 272: 12854-12861, 1997.
6. Argaud D, Zhang Q, Pan W, Maitra S, Pilkis SJ, Lange AJ. Regulation of rat liver glucose-6-phosphatase gene expression in different nutritional and hormonal states. Gene structure and 5′-flanking sequence. Diabetes 45: 1563-1571, 1996.
7. Ayala JE, Streeper RS, Desgrosellier JS, Durham SK, Suwanichkul A, Svitek CA, Goldman JK, Barr FG, Powell DR, O'Brien RM. Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters. Transcription factor FKHR binds the insulin response sequence. Diabetes 48: 1885-1889, 1999.
8. Carriere V, Le Gall M, Gouyon-Saumande F, Schmoll D, Brot-Laroche E, Chauffeton V, Chambaz J, Rousset M. Intestinal glucose-dependent expression of glucose-6-phosphatase. Involvement of the aryl receptor nuclear translocator transcription factor. J Biol Chem 280: 20094-20101, 2005.
9. Collier JJ, Doan TTT, Daniels MC, Schurr JR, Kolls JK, Scott DK. c-Myc is required for the glucose-mediated induction of metabolic enzyme genes. J Biol Chem 278: 6588-6595, 2003.
10. Forest CD, O'Brien RM, Lucas PC, Magnuson MA, Granner DK. Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence. Mol Endocrinol 4: 1302-1310, 1990.
11. Gautier-Stein A, Mithieux G, Rajas F. A distal region involving hepatocyte nuclear factor 4alpha and CAAT/enhancer binding protein markedly potentiates the protein kinase A stimulation of the glucose-6-phosphatase promoter. Mol Endocrinol 19: 163-174, 2005.
12. Groen AK, van Roermund CWT, Vervoorn RC, Tager JM. Control of gluconeogenesis in rat liver cells. Flux control coefficients of the enzymes in the gluconeogenic pathway in the absence and presence of glucagon. Biochem J 237: 379-389, 1986.
13. Haycock JW, Becker L, Ang L, Furukawa Y, Hornykiewicz O, Kish SJ. Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum. J Neurochem 87: 574-585, 2003.
14. Henquin JC. Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 49: 1751-1760, 2000.
15. Hohmeier HE, Mulder H, Chen G, Henkel-Rieger R, Prentki M, Newgard CB. Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion. Diabetes 49: 424-430, 2000.
16. Ishii S, Iizuka K, Miller BC, Uyeda K. Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription. Proc Natl Acad Sci USA 101: 15597-15602, 2004.
17. Kawaguchi T, Takenoshita M, Kabashima T, Uyeda K. Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein. Proc Natl Acad Sci USA 98: 13710-13715, 2001.
18. Khan A, Chandramouli V, Ostenson CG, Berggren PO, Low H, Landau BR, Efendic S. Glucose cycling is markedly enhanced in pancreatic islets of obese hyperglycemic mice. Endocrinology 126: 2413-2416, 1990.
19. Khan A, Hong-Lie C, Landau BR. Glucose-6-phosphatase activity in islets from ob/ob and lean mice and the effect of dexamethasone. Endocrinology 136: 1934-1938, 1995.
20. Koo SH, Towle HC. Glucose regulation of mouse S14 gene expression in hepatocytes. Involvement of a novel transcription factor complex. J Biol Chem 275: 5200-5207, 2000.
21. Krylov D, Olive M, Vinson C. Extending dimerization interfaces: the bZIP basic region can form a coiled coil. EMBO J 14: 5329-5337, 1995.
22. Lange AJ, Argaud D, El-Maghrabi MR, Pan W, Maitra SR, Pilkis SJ. Isolation of a cDNA for the catalytic subunit of rat liver glucose-6- phosphatase: regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP. Biochem Biophys Res Commun 201: 302-309, 1994.
23. Laybutt DR, Sharma A, Sgroi DC, Gaudet J, Bonner-Weir S, Weir GC. Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia. J Biol Chem 277: 10912-10921, 2002.
24. Lentner M, Bishop T. Experimental Design and Analysis (2nd ed.). Blacksburg, VA: Valley Book, 1993.
25. Lin B, Morris DW, Chou JY. Hepatocyte nuclear factor 1alpha is an accessory factor required for activation of glucose-6-phosphatase gene transcription by glucocorticoids. DNA Cell Biol 17: 967-974, 1998.
26. Lin B, Morris DW, Chou JY. The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation. Biochemistry 36: 14096-14106, 1997.
27. Liu Z, Thompson KS, Towle HC. Carbohydrate regulation of the rat L-type pyruvate kinase gene requires two nuclear factors: LF-A1 and a member of the c-myc family. J Biol Chem 268: 12787-12795, 1993.
28. Ma L, Robinson LN, Towle HC. ChREBP·Mlx is the principal mediator of glucose-induced gene expression in the liver. J Biol Chem 281: 28721-28730, 2006.
29. Ma L, Tsatsos NG, Towle HC. Direct role of ChREBP-Mlx in regulating hepatic glucose-responsive genes. J Biol Chem 280: 12019-12027, 2005.
30. Marie S, Diaz-Guerra MJ, Miquerol L, Kahn A, Iynedjian PB. The pyruvate kinase gene as a model for studies of glucose-dependent regulation of gene expression in the endocrine pancreatic beta-cell type. J Biol Chem 268: 23881-23890, 1993.
31. Massillon D. Regulation of the glucose-6-phosphatase gene by glucose occurs by transcriptional and post-transcriptional mechanisms. Differential effect of glucose and xylitol. J Biol Chem 276: 4055-4062, 2001.
32. Massillon D, Barzilai N, Chen W, Hu M, Rossetti L. Glucose regulates in vivo glucose-6-phosphatase gene expression in the liver of diabetic rats. J Biol Chem 271: 9871-9874, 1996.
33. Massillon D, Chen W, Barzilai N, Prus-Wertheimer D, Hawkins M, Liu R, Taub R, Rossetti L. Carbon flux via the pentose phosphate pathway regulates the hepatic expression of the glucose-6-phosphatase and phosphoenolpyruvate carboxykinase genes in conscious rats. J Biol Chem 273: 228-234, 1998.
34. Matschinsky FM, Glaser B, Magnuson MA. Pancreatic beta-cell glucokinase. Closing the gap between theoretical concepts and experimental realities. Diabetes 47: 307-315, 1998.
35. O'Callaghan BL, Koo SH, Wu Y, Freake HC, Towle HC. Glucose regulation of the acetyl-CoA carboxylase promoter PI in rat hepatocytes. J Biol Chem 276: 16033-16039, 2001.
36. Olive M, Krylov D, Echlin DR, Gardner K, Taparowsky E, Vinson C. A dominant negative to activation protein-1 (AP1) that abolishes DNA binding and inhibits oncogenesis. J Biol Chem 272: 18586-18594, 1997.
37. Pearson WR, Wood T, Zhang Z, Miller W. Comparison of DNA sequences with protein sequences. Genomics 46: 24-36, 1997.
38. Pedersen KB, Vedeckis WV. Quantification and glucocorticoid regulation of glucocorticoid receptor transcripts in two human leukemic cell lines. Biochemistry 42: 10978-10990, 2003 (Corrigendum Biochemistry 45: 6550, 2006).
39. Rufo C, Teran-Garcia M, Nakamura MT, Koo SH, Towle HC, Clarke SD. Involvement of a unique carbohydrate-responsive factor in the glucose regulation of rat liver fatty-acid synthase gene transcription. J Biol Chem 276: 21969-21975, 2001.
40. Schmoll D, Wasner C, Hinds CJ, Allan BB, Walther R, Burchell A. Identification of a cAMP response element within the glucose-6-phosphatase hydrolytic subunit gene promoter which is involved in the transcriptional regulation by cAMP and glucocorticoids in H4IIE hepatoma cells. Biochem J 338: 457-463, 1999.
41. Schmoll D, Watkins SL, Wasner C, Walther R, Burchell A. Glucose induces glucose 6-phosphatase hydrolytic subunit gene transcription in an insulinoma cell line (INS-1). FEBS Lett 443: 53-56, 1999.
42. Scott DK, Collier JJ, Doan TTT, Bunnell AS, Daniels MC, Eckert DT, O'Doherty RM. A modest glucokinase overexpression in the liver promotes fed expression levels of glycolytic and lipogenic enzyme genes in the fasted state without altering SREBP-1c expression. Mol Cell Biochem 254: 327-337, 2003.
43. Shih HM, Liu Z, Towle HC. Two CACGTG motifs with proper spacing dictate the carbohydrate regulation of hepatic gene transcription. J Biol Chem 270: 21991-21997, 1995.
44. Stoeckman AK, Ma L, Towle HC. Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes. J Biol Chem 279: 15662-15669, 2004.
45. Streeper RS, Eaton EM, Ebert DH, Chapman SC, Svitek CA, O'Brien RM. Hepatocyte nuclear factor-1 acts as an accessory factor to enhance the inhibitory action of insulin on mouse glucose-6-phosphatase gene transcription. Proc Natl Acad Sci USA 95: 9208-9213, 1998.
46. Streeper RS, Svitek CA, Chapman S, Greenbaum LE, Taub R, O'Brien RM. A multicomponent insulin response sequence mediates a strong repression of mouse glucose-6-phosphatase gene transcription by insulin. J Biol Chem 272: 11698-11701, 1997.
47. Streeper RS, Svitek CA, Goldman JK, O'Brien RM. Differential role of hepatocyte nuclear factor-1 in the regulation of glucose-6-phosphatase catalytic subunit gene transcription by cAMP in liver- and kidney-derived cell lines. J Biol Chem 275: 12108-12118, 2000.
48. Tokuyama Y, Sturis J, DePaoli AM, Takeda J, Stoffel M, Tang J, Sun X, Polonsky KS, Bell GI. Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat. Diabetes 44: 1447-1457, 1995.
49. Trinh K, Minassian C, Lange AJ, O'Doherty RM, Newgard CB. Adenovirus-mediated expression of the catalytic subunit of glucose-6-phosphatase in INS-1 cells. Effects on glucose cycling, glucose usage, and insulin secretion. J Biol Chem 272: 24837-24842, 1997.
50. Trinh KY, O'Doherty RM, Anderson P, Lange AJ, Newgard CB. Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats. J Biol Chem 273: 31615-31620, 1998.
51. Trumper A, Trumper K, Trusheim H, Arnold R, Goke B, Horsch D. Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling. Mol Endocrinol 15: 1559-1570, 2001.
52. Vander Kooi BT, Onuma H, Oeser JK, Svitek CA, Allen SR, Vander Kooi CW, Chazin WJ, O'Brien RM. The glucose-6-phosphatase catalytic subunit gene promoter contains both positive and negative glucocorticoid response elements. Mol Endocrinol 19: 3001-3022, 2005.
53. Wang H, Wollheim CB. ChREBP rather than USF2 regulates glucose stimulation of endogenous L-pyruvate kinase expression in insulin-secreting cells. J Biol Chem 277: 32746-32752, 2002.
54. Yamashita H, Takenoshita M, Sakurai M, Bruick RK, Henzel WJ, Shillinglaw W, Arnot D, Uyeda K. A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver. Proc Natl Acad Sci USA 98: 9116-9121, 2001.