Mice with cav-1 gene disruption have benign stromal lesions and compromised epithelial differentiation

Experimental and Molecular Pathology

Volumn 84, Issue 2, 2008, Pages 131-140

  Yang, Guang ^a   Timme, Terry L ^a,b   Naruishi, Koji ^a   Fujita, Tetsuo ^a   Fattah, El Moataz Abdel ^a   Cao, Guangwen ^a   Rajocopolan, Kartik ^a   Troung, Luan D ^c   Thompson, Timothy C ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c HOUSTON METHODIST HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CAVEOLIN 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL MEMBRANE; CONTROLLED STUDY; EPITHELIUM CELL; GENE DISRUPTION; KIDNEY DISTAL TUBULE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STROMA CELL; SURVIVAL;

ANIMALS; BIOLOGICAL MARKERS; CAVEOLIN 1; CELL DIFFERENTIATION; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; GENITALIA; KERATINS; LONGEVITY; LUNG; MALE; MAMMARY GLANDS, ANIMAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PANCREAS; SPLEEN; STROMAL CELLS; URINARY BLADDER;

MUS;

EID: 40949159623     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2007.08.004     Document Type: Article

References (67)

1. Aldred M.A., et al. Caveolin-1 and caveolin-2, together with three bone morphogenetic protein-related genes, may encode novel tumor suppressors down-regulated in sporadic follicular thyroid carcinogenesis. Cancer Res. 63 (2003) 2864-2871
2. Bagnoli M., et al. Downmodulation of caveolin-1 expression in human ovarian carcinoma is directly related to alpha-folate receptor overexpression. Oncogene 19 (2000) 4754-4763
3. Bender F.C., et al. Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity. Cancer Res. 60 (2000) 5870-5878
4. Bocker W., et al. Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept. Lab. Invest. 82 (2002) 737-746
5. Boecker W., and Buerger H. Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: a new progenitor (adult stem) cell concept. Cell Prolif. 36 Suppl 1 (2003) 73-84
6. Campbell L., et al. Caveolin-1 overexpression predicts poor disease-free survival of patients with clinically confined renal cell carcinoma. Br. J. Cancer 89 (2003) 1909-1913
7. Cao G., et al. Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis. Am. J. Pathol. 162 (2003) 1241-1248
8. Capozza F., et al. Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation. Am. J. Pathol. 162 (2003) 2029-2039
9. Carrion R., et al. Caveolin expression in adult renal tumors. Urol. Oncol. 21 (2003) 191-196
10. Carver L.A., and Schnitzer J.E. Caveolae: mining little caves for new cancer targets. Nat. Rev., Cancer 3 (2003) 571-581
11. Davidson B., et al. Caveolin-1 expression in advanced-stage ovarian carcinoma-a clinicopathologic study. Gynecol. Oncol. 81 (2001) 166-171
12. Davidson B., et al. Caveolin-1 expression in ovarian carcinoma is MDR1 independent. Am. J. Clin. Pathol. 117 (2002) 225-234
13. Drab M., et al. Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science 293 (2001) 2449-2452
14. Engelman J.A., et al. Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth. J. Biol. Chem. 272 (1997) 16374-16381
15. Fielding C.J., and Fielding P.E. Caveolae and intracellular trafficking of cholesterol. Adv. Drug Deliv. Rev. 49 (2001) 251-264
16. Fong A., et al. Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation. Am. J. Clin. Pathol. 120 (2003) 93-100
17. Galbiati F., et al. Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. EMBO J. 17 (1998) 6633-6648
18. Galbiati F., et al. Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism. Mol. Biol. Cell 12 (2001) 2229-2244
19. Gavrieli Y., et al. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119 (1992) 493-4501
20. Hakem R., and Mak T.W. Animal models of tumor-suppressor genes. Annu. Rev. Genet. 35 (2001) 209-241
21. Ho C.C., et al. Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation. Am. J. Pathol. 161 (2002) 1647-1656
22. Horiguchi A., et al. Impact of caveolin-1 expression on clinicopathological parameters in renal cell carcinoma. J. Urol. 172 (2004) 718-722
23. Hu Y.C., et al. Profiling of differentially expressed cancer-related genes in esophageal squamous cell carcinoma (ESCC) using human cancer cDNA arrays: overexpression of oncogene MET correlates with tumor differentiation in ESCC. Clin. Cancer Res. 7 (2001) 3519-3525
24. Hung K.F., et al. The biphasic differential expression of the cellular membrane protein, caveolin-1, in oral carcinogenesis. J. Oral Pathol. Med. 32 (2003) 461-467
25. Ito Y., et al. Caveolin-1 overexpression is an early event in the progression of papillary carcinoma of the thyroid. Br. J. Cancer 86 (2002) 912-916
26. Joo H.J., et al. Increased expression of caveolin-1 and microvessel density correlates with metastasis and poor prognosis in clear cell renal cell carcinoma. BJU Int. 93 (2004) 291-296
27. Kato K., et al. Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage. Cancer 94 (2002) 929-933
28. Kato T., et al. Difference of caveolin-1 expression pattern in human lung neoplastic tissue. Atypical adenomatous hyperplasia, adenocarcinoma and squamous cell carcinoma. Cancer Lett. 214 (2004) 121-128
29. Koleske A.J., et al. Reduction of caveolin and caveolae in oncogenically transformed cells. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 1381-1385
30. Kurzchalia T.V., et al. VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles. J. Cell Biol. 118 (1992) 1003-1014
31. Lee S.W., et al. Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells. Oncogene 16 (1998) 1391-1397
32. Lee H., et al. Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia. Am. J. Pathol. 161 (2002) 1357-1369
33. Massimino M.L., et al. Involvement of caveolae and caveolae-like domains in signalling, cell survival and angiogenesis. Cell. Signal. 14 (2002) 93-98
34. Mouraviev V., et al. The role of caveolin-1 in androgen insensitive prostate cancer. J. Urol. 168 (2002) 1589-1596
35. Park D.S., et al. Caveolin-1 null (-/-) mice show dramatic reductions in life span. Biochemistry 42 (2003) 15124-15131
36. Parton R.G. Caveolae and caveolins. Curr. Opin. Cell Biol. 8 (1996) 542-548
37. Parton R.G. Cell biology. Life without caveolae. Science 293 (2001) 2404-2405
38. Parton R.G. Caveolae-from ultrastructure to molecular mechanisms. Nat. Rev., Mol. Cell Biol. 4 (2003) 162-167
39. Patlolla J.M., et al. Overexpression of caveolin-1 in experimental colon adenocarcinomas and human colon cancer cell lines. Oncol. Rep. 11 (2004) 957-963
40. Racine C., et al. Reduction of caveolin 1 gene expression in lung carcinoma cell lines. Biochem. Biophys. Res. Commun. 255 (1999) 580-586
41. Rajjayabun P.H., et al. Caveolin-1 expression is associated with high-grade bladder cancer. Urology 58 (2001) 811-814
42. Razani B., et al. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J. Biol. Chem. 276 (2001) 38121-38138
43. Razani B., et al. Caveolin-1, a putative tumour suppressor gene. Biochem. Soc. Trans. 29 (2001) 494-499
44. Razani B., et al. Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae. Mol. Cell Biol. 22 (2002) 2329-2344
45. Rothberg K.G., et al. Caveolin, a protein component of caveolae membrane coats. Cell 68 (1992) 673-682
46. Sagara Y., et al. Clinical significance of caveolin-1, caveolin-2 and HER2/neu mRNA expression in human breast cancer. Br. J. Cancer 91 (2004) 959-965
47. Sanchez-Carbayo M., et al. Molecular profiling of bladder cancer using cDNA microarrays: defining histogenesis and biological phenotypes. Cancer Res. 62 (2002) 6973-6980
48. Satoh T., et al. Caveolin-1 expression is a predictor of recurrence-free survival in pT2N0 prostate carcinoma diagnosed in Japanese patients. Cancer 97 (2003) 1225-1233
49. Shaul P.W., and Anderson R.G. Role of plasmalemmal caveolae in signal transduction. Am. J. Physiol. 275 (1998) L843-L851
50. Smart E.J., et al. Caveolins, liquid-ordered domains, and signal transduction. Mol. Cell Biol. 19 (1999) 7289-7304
51. Sunaga N., et al. Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer. Cancer Res. 64 (2004) 4277-4285
52. Suzuoki M., et al. Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma. Br. J. Cancer 87 (2002) 1140-1144
53. Terris B., et al. Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas. Am. J. Pathol. 160 (2002) 1745-1754
54. Thompson T., et al. Caveolin-1: a complex and provocative therapeutic target in prostate cancer and potentially other malignancies. Emerg. Ther. Targets 3 (1999) 337-346
55. Thompson T.C., et al. Molecular pathways that underlie prostate cancer progression: the role of caveolin-1. In: Chung L. (Ed). Prostate Cancer in the 21st Century (2001), Humana Press
56. Wiechen K., et al. Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas. Am. J. Pathol. 158 (2001) 833-839
57. Wikman H., et al. Caveolins as tumour markers in lung cancer detected by combined use of cDNA and tissue microarrays. J. Pathol. 203 (2004) 584-593
58. Williams T.M., et al. Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice. Mol. Biol. Cell 14 (2003) 1027-1042
59. Williams T.M., et al. Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. J. Biol. Chem. 279 (2004) 51630-51646
60. Williams T.M., et al. Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of Cav-1 delays advanced prostate tumor development in TRAMP mice. J. Biol. Chem. 10 (2005) 1074
61. Woodman S.E., et al. Urogenital alterations in aged male caveolin-1 knockout mice. J. Urol. 171 (2004) 950-957
62. Yang G., et al. Perineural invasion of prostate carcinoma cells is associated with reduced apoptotic index. Cancer 78 (1996) 1267-1271
63. Yang G., et al. Elevated expression of caveolin is associated with prostate and breast cancer. Clin. Cancer Res. 4 (1998) 1873-1880
64. Yang G., et al. Caveolin-1 expression in clinically confined human prostate cancer: a novel prognostic marker. Cancer Res. 59 (1999) 5719-5723
65. Yang G., et al. Elevated caveolin-1 levels in African-American versus White-American prostate cancer. Clin. Cancer Res. 6 (2000) 3430-3433
66. Yoo S.H., et al. Expression of caveolin-1 is associated with poor prognosis of patients with squamous cell carcinoma of the lung. Lung Cancer 42 (2003) 195-202
67. Zhao Y.Y., et al. Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 11375-11380