Perifosine as potential anti-cancer agent inhibits proliferation, migration, and tube formation of human umbilical vein endothelial cells

Molecular and Cellular Biochemistry

Volumn 368, Issue 1-2, 2012, Pages 1-8

  Wang, Feng Ze ^a   Fei, Hong Rong ^a   Li, Xiao Qian ^a   Shi, Renjiu ^a   Wang, De Cai ^a  

^a TAISHAN MEDICAL UNIVERSITY   (China)

Author keywords

Angiogenesis; HUVEC; Perifosine; PI3K Akt

Indexed keywords

CYCLIN B1; MITOGEN ACTIVATED PROTEIN KINASE P38; PERIFOSINE; PROTEIN KINASE B; PROTEIN P21;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL MIGRATION; CELL PROLIFERATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; CELL LINE; CELL MOVEMENT; CYCLIN B1; G2 PHASE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PHOSPHORYLCHOLINE; PROTO-ONCOGENE PROTEINS C-AKT; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84864368490     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-0986-z     Document Type: Article

References (21)

1. Folkman J (2006) Angiogenesis. Annu Rev Med 57:1-18. doi: 10.1146/annurev.med.57.121304.131306 (Pubitemid 43261975)
2. Libert N, Tourtier JP, Védrine L, Chargari C (2010) Inhibitors of angiogenesis: new hopes for oncologists new challenges for anesthesiologists. Anesthesiology 113(3):704-712. doi:10.1097/ ALN.0b013e3181ed098d
3. Cook KM, Figg WD (2010) Angiogenesis inhibitors: current strategies and future prospects. CA Cancer J Clin 60(4):222-243. doi:10.3322/caac.20075
4. Pinto A, Redondo A, Zamora P, Castelo B, Espinosa E (2010) Angiogenesis as a therapeutic target in urothelial carcinoma. Anticancer Drugs 21(10):890-896. doi:10.1097/CAD.0b013e32 833e83b2
5. He L, Wu Y, Lin L, Wang J, Wu Y, Chen Y, Yi Z, Liu M, Pang X (2011) Hispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2-mediated PI3K/Akt/ m TOR signaling pathway. Cancer Sci 102(1):219-225. doi:10.1111/j.1349-7006.2010.01778.x
6. Chetty C, Lakka SS, Bhoopathi P, Rao JS (2010) MMP-2 alters VEGF expression via alpha Vbeta3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells. Int J Cancer 127(5): 1081-1095. doi:10.1002/ijc.25134
7. Ikegami D, Akiyama H, Suzuki A, Nakamura T, Nakano T, Yoshikawa H, Tsumaki N (2011) Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development 138(8):1507-1519. doi:10.1242/dev. 057802
8. Khalil A, Morgan RN, Adams BR, Golding SE, Dever SM, Rosenberg E, Povirk LF, Valerie K (2011) ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks. Cell Cycle 10(3):481-491
9. Kloo B, Nagel D, Pfeifer M, Grau M, Düwel M, Vincendeau M, Dörken B, Lenz P, Lenz G, Krappmann D (2011) Critical role of PI3K signaling for NF-kappa B-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells. Proc Natl Acad Sci USA 108(1):272-277. doi:10.1073/pnas. 1008969108
10. Jiang BH, Liu LZ (2009) PI3K/PTEN signaling in angiogenesis and tumorigenesis. Adv Cancer Res 102:19-65. doi:10.1016/ S0065-230X(09)02002-8
11. La Rusch GA, Mahdi F, Shariat-Madar Z, Adams G, Sitrin RG, Zhang WM, Mc Crae KR, Schmaier AH (2010) Factor XII stimulates ERK1/2 and Akt through u PAR, integrins, and the EGFR to initiate angiogenesis. Blood 115(24):5111-5120. doi: 10.1182/blood-2009-08-236430
12. Fei HR, Chen G, Wang JM, Wang FZ (2010) Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation. Cytotechnology 62(5):449-460. doi:10.1007/s10616-010-9299- 4
13. Fu L, Kim YA, Wang X, Wu X, Yue P, Lonial S, Khuri FR, Sun SY (2009) Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the m TOR axis and induces autophagy. Cancer Res 69(23):8967-8976. doi:10.1158/0008-5472.CAN-09-2190
14. Kumar A, Fillmore HL, Kadian R, Broaddus WC, Tye GW, Van Meter TE (2009) The alkylphospholipid perifosine induces apoptosis and p21-mediated cell cycle arrest in medulloblastoma. Mol Cancer Res 7(11):1813-1821. doi:10.1158/1541- 7786.MCR-09-0069
15. Park HJ, Zhang Y, Georgescu SP, Johnson KL, Kong D, Galper JB (2006) Human umbilical vein endothelial cells and human dermal microvascular endothelial cells offer new insights into the relationship between lipid metabolism and angiogenesis. Stem Cell Rev 2(2):93-102. doi:10.1007/s12015-006- 0015-x (Pubitemid 46132376)
16. Wu P, Hu YZ (2010) PI3K/Akt/m TOR pathway inhibitors in cancer: a perspective on clinical progress. Curr Med Chem 17(35):4326-4341
17. Falasca M (2010) PI3K/Akt signalling pathway specific inhibi-tors: a novel strategy to sensitize cancer cells to anti-cancer drugs. Curr Pharm Des 16(12):1410-1416
18. Leonard R, Hardy J, van Tienhoven G, Houston S, Simmonds P, David M, Mansi J (2001) Randomized, double-blind, placebo-controlled, multicenter trial of 6% miltefosine solution, a topical chemotherapy in cutaneous metastases from breast cancer. J Clin Oncol 19:4150-4159 (Pubitemid 33049533)
19. Tang JY, Li S, Li ZH, Zhang ZJ, Hu G, Cheang LC, Alex D, Hoi MP, Kwan YW, Chan SW, Leung GP, Lee SM (2010) Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC PLo S One 5(7):e11822. doi:10.1371/journal.pone. 0011822
20. Huang D, Ding Y, Luo WM, Bender S, Qian CN, Kort E, Zhang ZF, Vanden Beldt K, Duesbery NS, Resau JH, Teh BT (2008) Inhibition of MAPK kinase signaling pathways suppressed renal cell carcinoma growth and angiogenesis in vivo. Cancer Res 68(1):81-88. doi:10.1158/0008-5472.CAN-07-5311 (Pubitemid 351380108)
21. Hiarini F, Del Sole M, Mongiorgi S, Gaboardi GC, Cappellini A, Mantovani I, Follo MY, Mc Cubrey JA, Martelli AM (2008) The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in mul-tidrug-resistant human T-acute leukemia cells by a JNK-depen-dent mechanism. Leukemia 22(6):1106-1116. doi:10.1038/ leu.2008.79 (Pubitemid 351833776)