Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis

Blood

Volumn 115, Issue 24, 2010, Pages 5111-5120

  LaRusch, Gretchen A ^a   Mahdi, Fakhri ^b   Shariat Madar, Zia ^b   Adams, Gregory ^a   Sitrin, Robert G ^c   Zhang, Wan Ming ^a   McCrae, Keith R ^a   Schmaier, Alvin H ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; BETA1 INTEGRIN; BLOOD CLOTTING FACTOR 12; BROXURIDINE; EPIDERMAL GROWTH FACTOR RECEPTOR; HIGH MOLECULAR WEIGHT KININOGEN; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; UROKINASE RECEPTOR; WORTMANNIN; ZINC ION; ENZYME INHIBITOR;

ANGIOGENESIS; ANIMAL TISSUE; AORTA; ARTICLE; BINDING SITE; CELL INTERACTION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL DIVISION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION; PHYSIOLOGY; THORACIC AORTA; UMBILICAL VEIN;

ANIMALS; AORTA, THORACIC; CELL DIVISION; CELLS, CULTURED; ENDOTHELIAL CELLS; ENZYME INHIBITORS; FACTOR XII; HUMANS; INTEGRINS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; UMBILICAL VEINS;

EID: 77954672298     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-08-236430     Document Type: Article

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