Male fertility, obesity, and bariatric surgery

Reproductive Sciences

Volumn 19, Issue 8, 2012, Pages 778-785

  Reis, Leonardo Oliveira ^a   Dias, Fernando Goulart Fernandes ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

gastric bypass; infertility; morbid obesity; reproduction; reversibility; sexual function; treatment; weight loss

Indexed keywords

BARIATRIC SURGERY; CHROMATIN; CRYOPRESERVATION; DISEASE ASSOCIATION; DNA FRAGMENTATION; FEMALE INFERTILITY; FERTILIZATION; HEREDITY; HORMONAL REGULATION; MALE INFERTILITY; OBESITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SEMEN ANALYSIS; SEXUAL DYSFUNCTION; SPERM PRESERVATION; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; THERMOREGULATION; WEIGHT REDUCTION;

BARIATRIC SURGERY; DNA FRAGMENTATION; HORMONES; HUMANS; INFERTILITY, MALE; MALE; OBESITY; SEMEN ANALYSIS; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; WEIGHT LOSS;

EID: 84864361773     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719112440053     Document Type: Review

References (75)

1. Obesity and reproduction: an educational bulletin. Fertil Steril. 2008 ; 90 (5 suppl). S21 - S29
2. Hinz S, Rais-Bahrami S, Kempkensteffen C, Weiske WH, Miller K, Magheli A. Effect of obesity on sex hormone levels, antisperm antibodies, and fertility after vasectomy reversal. Urology. 2010 ; 76 (4). 851-856
3. Santos LM, Oliveira IV, Peters LR, Conde WL. Trends in morbid obesity and in bariatric surgeries covered by the Brazilian public health system. Obes Surg. 2010 ; 20 (7). 943-948
4. Abdel-Halim RE. Obesity: 1000 years ago. Lancet. 2005 ; 366 (9481). 204
5. Brant WO, Myers JB, Carrell DT, Smith JF. Male athletic activities and their effects on semen and hormonal parameters. Phys Sportsmed. 2010 ; 38 (3). 114-120
6. Sigman M, Jarow J Campbell's Urology. 8 th ed. Philadelphia, PA: Saunders; 2002:1475-1531. Walsh , ed. Philadelphia, PA: Saunders ; 2002: 1475-1531.
7. Oehninger S. Clinical and laboratory management of male infertility: an opinion on its current status. J Androl. 2000 ; 21 (6). 814-821
8. Jensen TK, Andersson AM, Jorgensen N, et al. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril. 2004 ; 82 (4). 863-870 (Pubitemid 39346431)
9. Hammoud AO, Gibson M, Peterson M, Meikle W, Carrell DT. Impact of male obesity on infertility: a critical review of the current literature. Fertil Steril. 2008 ; 90 (4). 897-904
10. Trus TL, Pope GD, Finlayson SR. National trends in utilization and outcomes of bariatric surgery. Surg Endosc. 2005 ; 19 (5). 616-620 (Pubitemid 40898002)
11. Scopinaro N, Gianetta E, Adami GF, Friedman D, Traverso E, Marinari GM. Biliopancreatic diversion for obesity at eighteen years. Surgery. 1996 ; 119 (3). 261-268 (Pubitemid 26082661)
12. Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction. 4 th ed. Cambridge, MA: Cambridge University Press; 1999. Cambridge, MA: Cambridge University Press ; 1999 :
13. Guzick DS, Overstreet JW, Factor-Litvak P, et al. National Cooperative Reproductive Medicine Network. Sperm morphology, motility, and concentration in fertile and infertile men. N Engl J Med. 2001 ; 345 (19). 1388-1393
14. di Frega AS, Dale B, Di Matteo L, Wilding M. Secondary male factor infertility after Roux-en-Y gastric bypass for morbid obesity: case report. Hum Reprod. 2005 ; 20 (4). 997-998 (Pubitemid 40667846)
15. Sermondade N, Massin N, Boitrelle F, et al. Sperm parameters and male fertility after bariatric surgery: three case series. Reprod Biomed Online. 2011 ; 24 (2). 206-210
16. Pasquali R, Patton L, Gambineri A. Obesity and infertility. Curr Opin Endocrinol Diabetes Obes. 2007 ; 14 (6). 482-487 (Pubitemid 350059360)
17. Loret de Mola JR. Obesity and its relationship to infertility in men and women. Obstet Gynecol Clin N Am. 2009 ; 36 (2). 333-346
18. Reddy UM, Wapner RJ, Rebar RW, Tasca RJ. Infertility, assisted reproductive technology, and adverse pregnancy outcomes: executive summary of a National Institute of Child Health and Human Development workshop. Obstet Gynecol. 2007 ; 109 (4). 967-977 (Pubitemid 46559087)
19. Nguyen RH, Wilcox AJ, Skjaerven R, Baird DD. Men's body mass index and infertility. Hum Reprod. 2007 ; 17 (9). 2488-2493 (Pubitemid 47289065)
20. Magnusdottir EV, Thorsteinsson T, Thorsteinsdottir S, Heimisdottir M, Olafsdottir K. Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Hum Reprod. 2005 ; 20 (1). 208-215
21. Prentice AM, Jebb SA. Beyond body mass index. Obes Rev. 2001 ; 2 (3). 141-147 (Pubitemid 33755907)
22. Bonde JP, Ernst E, Jensen TK, et al. Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners. Lancet. 1998 ; 352 (9135). 1172-1177 (Pubitemid 28458531)
23. Slama R, Eustache F, Ducot B, et al. Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities. Hum Reprod. 2002 ; 17 (2). 503-515 (Pubitemid 34168467)
24. Castilla JA, Alvarez C, Aguilar J, González-Varea C, Gonzalvo MC, Martínez L. Influence of analytical and biological variation on the clinical interpretation of seminal parameters. Hum Reprod. 2006 ; 21 (4). 847-851
25. Avendaño C, Franchi A, Taylor S, Morshedi M, Bocca S, Oehninger S. Fragmentation of DNA in morphologically normal human spermatozoa. Fertil Steril. 2009 ; 91 (4). 1077-1084
26. Martini AC, Tissera A, Estofán D, et al. Overweight and seminal quality: a study of 794 patients. Fertil Steril. 2010 ; 94 (5). 1739-1743
27. MacDonald AA, Herbison GP, Showell M, Farquhar CM. The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis. Hum Reprod Update. 2010 ; 16 (3). 293-311
28. Sallmen M, Sandler DP, Hoppin JA, Blair A, Baird DD. Reduced fertility among overweight and obese men. Epidemiology. 2006 ; 17 (5). 520-523 (Pubitemid 44223059)
29. Fejes I, Koloszar S, Szollosi J, Zavaczki Z, Pal A. Is semen quality affected by male body fat distribution?. Andrologia. 2005 ; 37 (5). 155-119
30. Kort HI, Massey JB, Elsner CW, et al. Impact of body mass index values on sperm quantity and quality. J Androl. 2006 ; 27 (3). 450-542
31. Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril. 2010 ; 93 (7). 2222-2231
32. La Vignera S, Condorelli RA, Vicari E, Calogero AE. Negative effect of increased body weight on sperm conventional and nonconventional flow cytometric sperm parameters. J Androl. 2012 ; 33 (1). 53-58
33. Keltz J, Zapantis A, Jindal SK, Lieman HJ, Santoro N, Polotsky AJ. Overweight men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles. J Assist Reprod Genet. 2010 ; 27 (9-10). 539-544
34. Giagulli VA, Kaufman JM, Vermeulen A. Pathogenesis of the decreased androgen levels in obese men. J Clin Endocrinol Metab. 1994 ; 79 (4). 997-1000 (Pubitemid 24342237)
35. Tchernof A, Després JP, Bélanger A, et al. Reduced testosterone and adrenal C19 steroid levels in obese men. Metabolism. 1995 ; 44 (4). 513-519
36. Schneider G, Kirschner MA, Berkowitz R, Ertel NH. Increased estrogen production in obese men. J Clin Endocrinol Metab. 1979 ; 48 (4). 633-638 (Pubitemid 9167803)
37. Goyal HO, Robateau A, Braden TD, Williams CS, Srivastava KK, Ali K. Neonatal estrogen exposure of male rats alters reproductive functions at adulthood. Biol Reprod. 2003 ; 68 (6). 2081-2091 (Pubitemid 36686999)
38. Akingbemi BT. Estrogen regulation of testicular function. Reprod Biol Endocrinol. 2005 ; 3: 51
39. de Boer H, Verschoor L, Ruinemans-Koerts J, Jansen M. Letrozole normalizes serum testosterone in severely obese men with hypogonadotropic hypogonadism. Diabetes Obes Metab. 2005 ; 7 (3). 211-215 (Pubitemid 40542810)
40. Pavlovich CP, King P, Goldstein M, Schlegel PN. Evidence of a treatable endocrinopathy in infertile men. J Urol. 2001 ; 165 (3). 837-841 (Pubitemid 32156291)
41. Kumanov P, Nandipati K, Tomova A, Agarwal A. Inhibin B is a better marker of spermatogenesis than other hormones in the evaluation of male factor infertility. Fertil Steril. 2006 ; 86 (6). 332-338 (Pubitemid 44137444)
42. Winters SJ, Wang C, Abdelrahaman E, Hadeed V, Dyky MA, Brufsky A. Inhibin-B levels in healthy young adult men and prepubertal boys: is obesity the cause for the contemporary decline in sperm count because of fewer Sertoli cells?. J Androl. 2006 ; 27: 560-564 (Pubitemid 44126269)
43. Stellato RK, Feldman HA, Hamdy O, Horton ES, McKinlay JB. Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study. Diabetes Care. 2000 ; 23 (4). 490-494 (Pubitemid 30185792)
44. Luboshitzky R, Lavie L, Shen-Orr Z, Herer P. Altered luteinizing hormone and testosterone secretion in middle-aged obese men with obstructive sleep apnea. Obes Res. 2005 ; 13 (4). 780-786
45. Luboshitzky R, Zabari Z, Shen-Orr Z, Herer P, Lavie P. Disruption of the nocturnal testosterone rhythm by sleep fragmentation in normal men. J Clin Endocrinol Metab. 2001 ; 86 (3). 1134-1139 (Pubitemid 32322993)
46. Blank DM, Clark RV, Heymsfield SB, Rudman DR, Blank MS. Endogenous opioids and hypogonadism in human obesity. Brain Res Bull. 1994 ; 34 (6). 571-574 (Pubitemid 24187582)
47. Wozniak SE, Gee LL, Wachtel MS, Frezza EE. Adipose tissue: the new endocrine organ? A review article. Dig Dis Sci. 2009 ; 54 (9). 1847-1856
48. Farooqi IS, Wangensteen T, Collins S, et al. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N Engl J Med. 2007 ; 356 (3). 237-247 (Pubitemid 46143227)
49. Mounzih K, Lu R, Chehab FF. Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology. 1997 ; 138 (3). 1190-1193 (Pubitemid 27089777)
50. Jung A, Schill WB. Male infertility. Current life style could be responsible for infertility. MMW Fortschr Med. 2000 ; 142 (37). 31-33
51. Mulcahy JJ. Scrotal hypothermia and the infertile man. J Urol. 1984 ; 132 (3). 469-470 (Pubitemid 14026146)
52. Cabler S, Agarwal A, Flint M, Du Plessis SS. Obesity: modern man's fertility nemesis. Asian J Androl. 2010 ; 12 (4). 480-489
53. Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, Rimm EB. Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Ann Intern Med. 2003 ; 139 (3). 161-168
54. Feldman HA, Goldstein I, Hatzichkristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts male aging study. J Urol. 1994 ; 151 (1). 54-61 (Pubitemid 24046934)
55. Sullivan ME, Thompson CS, Dashwood MR, et al. Nitric oxide and penile erection: is erectile dysfunction another manifestation of vascular disease?. Cardiovasc Res. 1999 ; 43 (3). 658-665 (Pubitemid 29369264)
56. Niskanen L, Laaksonen DE, Punnonen K, Mustajoki P, Kaukua J, Rissanen A. Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome. Diabetes Obes Metab. 2004 ; 6: 208-215 (Pubitemid 38559701)
57. Kaukua J, Pekkarinen T, Sane T, Mustajoki P. Sex hormones and sexual function in obese men losing weight. Obes Res. 2003 ; 11 (6). 689-694 (Pubitemid 41151594)
58. Esposito K, Giugliano F, Di Palo C, et al. Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial. JAMA. 2004 ; 291 (24). 2978-2984 (Pubitemid 38802687)
59. Semple PA, Graham A, Malcolm Y, Beastall GH, Watson WS. Hypoxia, depression of testosterone, and impotence in pickwickian syndrome reversed by weight reduction. Br Med J (Clin Res Ed). 1984 ; 289 (6448). 801-802 (Pubitemid 14009923)
60. Leenen R, van der Kooy K, Seidell JC, Deurenberg P, Koppeschaar HP. Visceral fat accumulation in relation to sex hormones in obese men and women undergoing weight loss therapy. J Clin Endocrinol Metab. 1994 ; 78 (6). 1515-1520 (Pubitemid 24181029)
61. Pate RR, Pratt M, Blair SN, et al. Physical activity and public health. A recommendation from the centers for disease control and prevention and the American College of Sports Medicine. JAMA. 1995 ; 273 (5). 402-407
62. Bray GA. Uses and misuses of the new pharmacotherapy of obesity. Ann Med. 1999 ; 31 (1). 1-3 (Pubitemid 29134480)
63. Håkonsen LB, Thulstrup AM, Aggerholm AS, et al. Does weight loss improve semen quality and reproductive hormones? Results from a cohort of severely obese men. Reprod Health. 2011 ; 8: 24
64. Gastrointestinal surgery for severe obesity. Ann Intern Med. 1991 ; 115 (12). 956-961
65. Buchwald H, Williams SE. Bariatric surgery worldwide 2003. Obes Surg. 2004 ; 14 (9). 1157-1164 (Pubitemid 39458587)
66. Genco A, Cipriano M, Bacci V, et al. Bio Enterics Intragastric Balloon (BIB): a shortterm, double-blind, randomised, controlled, crossover study on weight reduction in morbidly obese patients. Int J Obes (Lond). 2006 ; 30 (1). 129-133 (Pubitemid 41790788)
67. Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery. A systematic review and meta-analysis. JAMA. 2 004 ; 292 (14). 1724-1737 (Pubitemid 39346675)
68. Maggard MA, Shugarman LR, Suttorp M, et al. Meta-analysis: surgical treatment of obesity. Ann Intern Med. 2005 ; 142 (7). 547-559
69. Shah DK, Ginsburg ES. Bariatric surgery and fertility. Curr Opin Obstet Gynecol. 2010 ; 22 (3). 248-254
70. Kremen AJ, Linner JH, Nelson CH. An experimental evaluation of the nutritional importance of proximal and distal small intestine. Ann Surg. 1954 ; 140 (3). 439-448
71. Payne JH, DeWind LT, Commons RR. Metabolic observations in patients with jejunocolic shunts. Am J Surg. 1963 ; 106: 273-289
72. Reis LO, Favaro WJ, Barreiro GC, et al. Erectile dysfunction and hormonal imbalance in morbidly obese male is reversed after gastric bypass surgery: a prospective randomized controlled trial. Int J Androl. 2010 ; 33 (5). 736-744
73. Bastounis EA, Karayiannakis AJ, Syrigos K, Zbar A, Makri GG, Alexiou D. Sex hormone changes in morbidly obese patients after vertical banded gastroplasty. Eur Surg Res. 1998 ; 30 (1). 43-47 (Pubitemid 28048519)
74. Globerman H, Shen-Orr Z, Karnieli E, Aloni Y, Charuzi I. Inhibin B in men with severe obesity and after weight reduction following gastroplasty. Endocr Res. 2005 ; 31 (1). 17-26 (Pubitemid 41419981)
75. Reis LO, Saade RD, Chaim EA, Oliveira LC, Fregonesi A, Ferreira U. Morbid Obese Men Present Poor Sperm Quality and While Hormonal and Sexual Functions Improve It Is Not Reversed After Gastric Bypass-A Long Term Follow-up. J Urol. 2010 ; 183 (4). e747 - e748