Inhibin-B levels in healthy young adult men and prepubertal boys: Is obesity the cause for the contemporary decline in sperm count because of fewer sertoli cells?

Journal of Andrology

Volumn 27, Issue 4, 2006, Pages 560-564

  Winters, Stephen J ^a,c   Wang, Chenxi ^a   Abdelrahaman, Eiman ^a   Hadeed, Venus ^b   Dyky, Mary Ann ^b   Brufsky, Adam ^b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c GENENTECH INC   (United States)

Author keywords

Male infertility; Puberty; Testis

Indexed keywords

FOLLITROPIN; INHIBIN B; LUTEINIZING HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; ARTICLE; BODY MASS; CELL COUNT; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FOLLITROPIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; LUTEINIZING HORMONE BLOOD LEVEL; MALE; OBESITY; PREPUBERTY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SERTOLI CELL; SPERMATOZOON COUNT; TESTOSTERONE BLOOD LEVEL;

ADOLESCENT; ADULT; BODY MASS INDEX; CELL COUNT; CHILD; CHILD, PRESCHOOL; HUMANS; INHIBINS; MALE; OBESITY; PUBERTY; SERTOLI CELLS; SEX HORMONE-BINDING GLOBULIN; SPERM COUNT; TESTOSTERONE;

EID: 33746394167     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: 10.2164/jandrol.05193     Document Type: Article

References (38)

1. Abdelrahaman E, Raghavan S, Baker L, Weinrich M, Winters SJ. Racial difference in circulating sex hormone-binding globulin levels in prepubertal boys. Metabolism. 2005;54:91-96.
2. Akingbemi BT, Hardy MP. Oestrogenic and antiandrogenic chemicals in the environment: effects on male reproductive health. Ann Med. 2001;33:391-403.
3. Anawalt BD, Bebb RA, Matsumoto AM, Groome NP, Illingworth PJ, McNeilly AS, Bremner WJ. Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction. J Clin Endocrinol Metab. 1996;81:3341-3345.
4. Andersson AM, Muller J, Skakkebaek NE. Different roles of prepubertal and postpubertal germ cells and Sertoli cells in the regulation of serum inhibin B levels. J Clin Endocrinol Metab. 1998;83:4451-4458.
5. Andersson AM, Petersen JH, Jorgensen N, Jensen TK, Skakkebaek NE. Serum inhibin B and follicle-stimulating hormone levels as tools in the evaluation of infertile men: significance of adequate reference values from proven fertile men. J Clin Endocrinol Metab. 2004;89:2873-2879.
6. Andersson AM, Skakkebaek NE. Serum inhibin B levels during male childhood and puberty. Mol Cell Endocrinol. 2001;180:103-107.
7. Attardi B, Keeping HS, Winters SJ, Kotsuji F, Maurer RA, Troen P. Rapid and profound suppression of messenger ribonucleic acid encoding follicle-stimulating hormone beta by inhibin from primate Sertoli cells. Mol Endocrinol. 1989;3:280-287.
8. Carlsen E, Olsson C, Petersen JH, Andersson AM, Skakkebaek NE. Diurnal rhythm in serum levels of inhibin B in normal men: relation to testicular steroids and gonadotropins. J Clin Endocrinol Metab. 1999;84:1664-1669.
9. Cortes D, Muller J, Skakkebaek NE. Proliferation of Sertoli cells during development of the human testis assessed by stereological methods. Int J Androl. 1987;10:589-596.
10. Giagulli VA, Kaufman JM, Vermeulen A. Pathogenesis of the decreased androgen levels in obese men. J Clin Endocrinol Metab. 1994;79:997-1000.
11. Glass AR, Burman KD, Dahms WT, Boehm TM. Endocrine function in human obesity. Metabolism. 1981;30:89-104.
12. Glass AR, Swerdloff RS, Bray GA, Dahms WT, Atkinson RL. Low serum testosterone and sex-hormone-binding-globulin in massively obese men. J Clin Endocrinol Metab. 1977;45:1211-1219.
13. Globerman H, Shen-Orr Z, Karnieli E, Aloni Y, Charuzi I. Inhibin B in men with severe obesity and after weight reduction following gastroplasty. Endocr Res. 2005;31:17-26.
14. Hill JO, Sidney S, Lewis CE, Tolan K, Scherzinger AL, Stamm ER. Racial differences in amounts of visceral adipose tissue in young adults: the CARDIA (Coronary Artery Risk Development in Young Adults) study. Am J Clin Nutr. 1999;69:381-387.
15. Jensen TK, Andersson AM, Hjollund NH, Scheike T, Kolstad H, Giwercman A, Henriksen TB, Ernst E, Bonde JP, Olsen J, McNeilly A, Groome NP, Skakkebaek NE. Inhibin B as a serum marker of spermatogenesis: correlation to differences in sperm concentration and follicle-stimulating hormone levels. A study of 349 Danish men. J Clin Endocrinol Metab. 1997;82:4059-4063.
16. Jensen TK, Andersson AM, Jorgensen N, Andersen AG, Carlsen E, Petersen JH, Skakkebaek NE. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril. 2004;82:863-870.
17. Jouannet P, Wang C, Eustache F, Kold-Jensen T, Auger J. Semen quality and male reproductive health: the controversy about human sperm concentration decline. Apmis. 2001;109:333-344.
18. Majumdar SS, Winters SJ, Plant TM. A study of the relative roles of follicle-stimulating hormone and luteinizing hormone in the regulation of testicular inhibin secretion in the rhesus monkey (Macaca mulatta). Endocrinology. 1997;138:1363-1373.
19. Marshall GR, Plant TM. Puberty occurring either spontaneously or induced precociously in rhesus monkey (Macaca mulatta) is associated with a marked proliferation of Sertoli cells. Biol Reprod. 1996;54:1192-1199.
20. Matthiesson KL, Robertson DM, Burger HG, McLachlan RI. Response of serum inhibin B and pro-alphaC levels to gonadotrophic stimulation in normal men before and after steroidal contraceptive treatment. Hum Reprod. 2003;18:734-743.
21. McLachlan RI, O'Donnell L, Stanton PG, Balourdos G, Frydenberg M, de Kretser DM, Robertson DM. Effects of testosterone plus medroxyprogesterone acetate on semen quality, reproductive hormones, and germ cell populations in normal young men. J Clin Endocrinol Metab. 2002;87:546-556.
22. Mruk DD, Cheng CY. Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis. Endocr Rev. 2004;25:747-806.
23. Ogden CL, Flegal KM, Carroll MD, Johnson CL. Prevalence and trends in overweight among US children and adolescents, 1999-2000. JAMA. 2002;288:1728-1732.
24. Oliva A, Spira A, Multigner L. Contribution of environmental factors to the risk of male infertility. Hum Reprod. 2001;16:1768-1776.
25. Orth JM, Gunsalus GL, Lamperti AA. Evidence from Sertoli cell-depleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development. Endocrinology. 1988;122:787-794.
26. Pauli EM, Legro RS, Dodson WC, Kunselman AR, Lee PA. Diminished paternity and gonadal function with increasing obesity in normal males. In: 86th Annual Meeting of the Endocrine Society. New Orleans, Louisiana, 2004:P3-P508.
27. Ramaswamy S, Marshall GR, McNeilly AS, Plant TM. Evidence that in a physiological setting Sertoli cell number is the major determinant of circulating concentrations of inhibin B in the adult male rhesus monkey (Macaca mulatta.). J Androl. 1999;20:430-434.
28. Seminara SB, Boepple PA, Nachtigall LB, Pralong FP, Khoury RH, Sluss PM, Lecain AE, Crowley WF Jr. Inhibin B in males with gonadotropin-releasing hormone (GnRH) deficiency: changes in serum concentration after shortterm physiologic GnRH replacement-a clinical research center study. J Clin Endocrinol Metab. 1996;81:3692-3696.
29. Sharpe RM. Declining sperm counts in men-is there an endocrine cause? J Endocrinol. 1993;136:357-360.
30. Sharpe RM, Irvine DS. How strong is the evidence of a link between environmental chemicals and adverse effects on human reproductive health? BMJ. 2004;328:447-451.
31. Sharpe RM, McKinnell C, Kivlin C, Fisher JS. Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood. Reproduction. 2003;125: 769-784.
32. Simorangkir DR, Marshall GR, Plant TM. Sertoli cell proliferation during prepubertal development in the rhesus monkey (Macaca mulatta) is maximal during infancy when gonadotropin secretion is robust. J Clin Endocrinol Metab. 2003;88:4984-4989.
33. Sodergard R, Backstrom T, Shanbhag V, Carstensen H. Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature. J Steroid Biochem. 1982;16:801-810.
34. Strain GW, Zumoff B, Kream J, Strain JJ, Deucher R, Rosenfeld RS, Levin J, Fukushima DK. Mild hypogonadotropic hypogonadism in obese men. Metabolism. 1982;31:871-875.
35. Strain GW, Zumoff B, Miller LK, Rosner W. Sex difference in the effect of obesity on 24-hour mean serum gonadotropin levels. Horm Metab Res. 2003;35:362-366.
36. Vermeulen A. Decreased androgen levels and obesity in men. Ann Med. 1996;28:13-15.
37. Winters SJ, Brufsky A, Weissfeld J, Trump DL, Dyky MA, Hadeed V. Testosterone, sex hormone-binding globulin, and body composition in young adult African American and Caucasian men. Metabolism. 2001;50:1242-1247.
38. Winters SJ, Plant TM. Partial characterization of circulating inhibin-B and pro-alpha C during development in the male rhesus monkey. Endocrinology. 1999;140:5497-5504.