Challenging the effectiveness of green tea in primary and tertiary cancer prevention

Journal of Cancer Research and Clinical Oncology

Volumn 138, Issue 8, 2012, Pages 1259-1270

  Fujiki, Hirota ^a   Imai, Kazue ^b   Nakachi, Kei ^b   Shimizu, Masahito ^c   Moriwaki, Hisataka ^c   Suganuma, Masami ^d  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^b RADIATION EFFECTS RESEARCH FOUNDATION   (Japan)

^c GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d SAITAMA CANCER CENTER   (Japan)

Author keywords

Apoptosis; Delayed cancer onset; GADD153; Green tea tablet; Phase II prevention trial; Prospective cohort study; TNF

Indexed keywords

ANTIESTROGEN; ANTINEOPLASTIC AGENT; CAFFEINE; CATECHIN; CELECOXIB; CURCUMIN; DOXORUBICIN; EPICATECHIN; EPICATECHIN GALLATE; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; ERLOTINIB; FLUOROURACIL; GEFITINIB; GREEN TEA EXTRACT; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MITOGEN ACTIVATED PROTEIN KINASE P38; PACLITAXEL; PLACEBO; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEIN P21; RETINOID; SULINDAC; TAMOXIFEN; TUMOR NECROSIS FACTOR ALPHA;

BREAST CANCER; CANCER INHIBITION; CANCER PREVENTION; CANCER RISK; COLORECTAL ADENOMA; COLORECTAL CANCER; CYTOKINE RELEASE; DIET SUPPLEMENTATION; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG SAFETY; ENDOSCOPIC POLYPECTOMY; ENZYME INHIBITION; FOOD INTAKE; GADD153 GENE; GENE EXPRESSION; HUMAN; IC 50; INTESTINE TUMOR; LIVER CANCER; LUNG CANCER; LUNG METASTASIS; LUNG TUMOR; MOUTH CANCER; NONHUMAN; P21 GENE; PRIMARY PREVENTION; PRIORITY JOURNAL; PROSTATE CANCER; REHABILITATION CARE; REVIEW; RISK REDUCTION; SKIN CANCER; STOMACH CANCER; TABLET; TEA; TISSUE DISTRIBUTION; TUMOR RECURRENCE;

ANIMALS; ANTICARCINOGENIC AGENTS; CATECHIN; FEMALE; HUMANS; MALE; NEOPLASMS; PHYTOTHERAPY; PLANT EXTRACTS; TEA;

EID: 84864356200     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-012-1250-y     Document Type: Review

References (66)

1. Adachi S, Nagao T, Ingolfsson HI, Maxfield FR, Andersen OS, Kopelovich L, Weinstein IB (2007) The inhibitory effect of (-)- epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells. Cancer Res 67:6493-6501 (Pubitemid 47037535)
2. Ahmad N, Feyes DK, Nieminen AL, Agarwal R, Mukhtar H (1997) Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. J Natl Cancer Inst 89:1881-1886 (Pubitemid 28009824)
3. Ben-Neriah Y, Karin M (2011) Inflammation meets cancer, with NF-jB as the matchmaker. Nat Immunol 12:715-723
4. Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A (2006) Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with highgrade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res 66:1234-1240 (Pubitemid 43165995)
5. Chen W, Dong Z, Valcic S, Timmermann BN, Bowden GT (1999) Inhibition of ultraviolet B-induced c-fos gene expression and p38 mitogen-activated protein kinase activation by (-)-epigallocatechin gallate in a human keratinocyte cell line. Mol Carcinog 24:79-84 (Pubitemid 29115909)
6. Conney AH, Wang ZY, Huang MT, Ho CT, Yang CS (1992) Inhibitory effect of oral administration of green tea on tumorigenesis by ultraviolet light, 12-O-tetra decanoylphorbol-13- acetate and N-nitrosodiethylamine in mice. CRC Press, Boca Raton, pp 361-373
7. El-Deiry WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y, Wiman KG, Mercer WE, Kastan MB, Kohn KW, Elledge SJ, Kinzler KW, Vogelstein B (1994) WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 54:1169-1174 (Pubitemid 24108052)
8. Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N, other National Surgical Adjivant Breast and Bowel Project Inverstigators (1998) Tamoxifen for prevention of breast cancer. Report of the national surgical adjuvant breast and bowel project P-1 study. J Natl Cancer Inst 90:1371-1388 (Pubitemid 28439961)
9. Fujiki H (1999) Two stages of cancer prevention with green tea. J Cancer Res Clin Oncol 125:589-597 (Pubitemid 29502339)
10. Fujiki H (2005) Green tea: health benefits as cancer preventive for humans. Chem Rec 5:119-132 (Pubitemid 41276860)
11. Fujiki H, Okuda T (1992) (-)-Epigallocatechin gallate. Drugs Future 17:462-464
12. Fujiki H, Suganuma M (2002) Green tea and cancer prevention. Proc Jpn Acad 78(B):263-270
13. Fujiki H, Suganuma M (2011) Tumor promoters-microcystin-LR, nodularin and TNF-a and human cancer development. Anticancer Agents Med Chem 11:4-18
14. Fujiki H, Suganuma M, Okabe S, Komori A, Sueoka E, Sueoka N, Kozu T, Sakai Y (1996) Japanese green tea as a cancer preventive in humans. Nutr Rev 54:S67-S70 (Pubitemid 27179940)
15. Fujiki H, Suganuma M, Okabe S, Sueoka E, Sueoka N, Fujimoto N, Goto Y, Matsuyama S, Imai K, Nakachi K (2001) Cancer prevention with green tea and monitoring by a new biomarker, hnRNP B1. Mutat Res 480-481:299-304
16. Fujiki H, Suganuma M, Imai K, Nakachi K (2002) Green tea: cancer preventive beverage and/or drug. Cancer Lett 188:9-13 (Pubitemid 35292323)
17. Fujiki H, Takeuchi H, Nishitani N, Yamanaka H, Suzuki K, Kurusu M, Suganuma M (2004) Carcinogenic potential of tobacco tarresistant Staphylococcus aureus in buccal cavity. J Cancer Res Clin Oncol 130:301-305 (Pubitemid 38680272)
18. Fujita Y, Yamane T, Tanaka M, Kuwata K, Okuzumi J, Takahashi T, Fujiki H, Okuda T (1989) Inhibitory effect of (-)-epigallocatechin gallate on carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine in mouse duodenum. Jpn J Cancer Res 80:503-505 (Pubitemid 20032474)
19. Gupta S, Hastak K, Ahmad N, Lewin JS, Mukhtar H (2001) Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols. Proc Natl Acad Sci USA 98:10350-10355 (Pubitemid 32803023)
20. Hecker E, Adolf W, Hergenhahn R, Schmidt R, Sorg B (1984) Irritant diterpene ester promoters of mouse skin: contributions to etiologies of environmental cancer and to biochemical mechanisms of carcinogenesis. In: Fujiki H, Hecker E, Moore RE, Sugimura T, Weinstein IB (eds) Cellular interactions by environmental tumor promoters. Jpn Sci Soc Press/VNU Science Press, BV, Tokyo/Utrecht, pp 3-36
21. Imai K, Suga K, Nakachi K (1997) Cancer-preventive effects of drinking green tea among a Japanese population. Prev Med 26:769-775 (Pubitemid 27508650)
22. Iwasaki M, Inoue M, Sasazuki S, Sawada N, Yamaji T, Shimazu T, Willett WC, Tsugane S (2010) Green tea drinking and subsequent risk of breast cancer in a population to based cohort of Japanese women. Breast Cancer Res 12:R88. (Epub ahead of print)
23. Komori A, Yatsunami J, Okabe S, Abe S, Hara K, Suganuma M, Kim SJ, Fujiki H (1993a) Anticarcinogenic activity of green tea polyphenols. Jpn J Clin Oncol 23:186-190
24. Komori A, Yatsunami J, Suganuma M, Okabe S, Abe S, Sakai A, Sasaki K, Fujiki H (1993b) Tumor necrosis factor acts as a tumor promoter in BALB/3T3 cell transformation. Cancer Res 53: 1982-1985 (Pubitemid 23145713)
25. Kuzuhara T, Sei Y, Yamaguchi K, Suganuma M, Fujiki H (2006) DNA and RNA as new binding targets of green tea catechins. J Biol Chem 281:17446-17456
26. Kuzuhara T, Tanabe A, Sei Y, Yamaguchi K, Suganuma M, Fujiki H (2007a) Synergistic effects of multiple treatments, and both DNA and RNA direct bindings on, green tea catechins. Mol Carcinog 46:640-645 (Pubitemid 47255181)
27. Kuzuhara T, Suganuma M, Kurusu M, Fujiki H (2007b) Helicobacter pylori-secreting protein Tipa is a potent inducer of chemokine gene expressions in stomach cancer cells. J Cancer Res Clin Oncol 133:287-296 (Pubitemid 46723496)
28. Kuzuhara T, Suganuma M, Fujiki H (2008) Green tea catechin as a chemical chaperone in cancer prevention. Cancer Lett 261:12-20
29. Laurie SA, Miller VA, Grant SC, Kris MG, Ng KK (2005) Phase 1 study of green tea extract in patients with advanced lung cancer. Cancer Chemother Pharmacol 55:33-38 (Pubitemid 40064493)
30. Nakachi K, Suemasu K, Suga K, Takeo T, Imai K, Higashi Y (1998) Influence of drinking green tea on breast cancer malignancy among Japanese patients. Jpn J Cancer Res 89:254-261 (Pubitemid 28197289)
31. Nakachi K, Matsuyama S, Miyake S, Suganuma M, Imai K (2000) Preventive effects of drinking green tea on cancer and cardiovascular disease: epidemiological evidence for multiple targeting prevention. BioFactors 13:49-54 (Pubitemid 32107344)
32. Narisawa T, Fukaura Y (1993) A very low dose of green tea polyphenols in drinking water prevents N-methyl-N-nitrosoureainduced colon carcinogenesis in F344 rats. Jpn J Cancer Res 84:1007-1009 (Pubitemid 23307832)
33. NCI, Dcpc, Chemoprevention Branch and Agent Development Committee (1996) Clinical development plan:tea extracts green tea polyphenols epigallocatechin gallate. J Cell Biochem 26S: 236-257
34. Nishida H, Omori M, Fukutomi Y, Ninomiya M, Nishiwaki S, Suganuma M, Moriwaki H, Muto Y (1994) Inhibitory effects of (-)-epigallocatechin gallate on spontaneous hepatoma in C3H/ HeNCrj mice and human hepatoma-derived PCL/PRF/5 cells. Jpn J Cancer Res 85:221-225 (Pubitemid 24103496)
35. Novoa I, Zeng H, Harding HP, Ron D (2001) Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2a. J Cell Biol 153:1011-1022
36. Ogunleye AA, Xue F, Michels KB (2010) Green tea consumption and breast cancer risk or recurrence: a meta-analysis. Breast Cancer Res Treat 119:477-484
37. Okabe S, Suganuma M, Hayashi M, Sueoka E, Komori A, Fujiki H (1997) Mechanisms of growth inhibition of human lung cancer cell line, PC-9, by tea polyphenols. Jpn J Cancer Res 88:639-643 (Pubitemid 27394047)
38. Okabe S, Ochiai Y, Aida M, Park K, Kim SJ, Nomura T, Suganuma M, Fujiki H (1999) Mechanistic aspects of green tea as a cancer preventive: effect of components on human stomach cancer cell lines. Jpn J Cancer Res 90:733-739 (Pubitemid 29381102)
39. Okabe S, Fujimoto N, Sueoka N, Suganuma M, Fujiki H (2001) Modulation of gene expression by (-)-epigallocatechin gallate in PC-9 cells using a cDNA expression array. Biol Pharm Bull (Tokyo) 24:883-886 (Pubitemid 32750311)
40. Okuda T, Mori K, Hayatsu H (1984) Inhibitory effect of tannins on direct-acting mutagens. Chem Pharm Bull (Tokyo) 32:3755-3758 (Pubitemid 14015779)
41. Okuda T, Mori K, Hatano T (1985) Relationship of the structure of tannins to the binding activities with hemoglobin and methylene blue. Chem Pharm Bull (Tokyo) 33:1424-1433
42. Pisters KM, Newman RA, Coldman B, Shin DM, Khuri FR, Hong WK, Glisson BS, Lee JS (2001) Phase 1 trial of oral green tea extract in adult patients with solid tumors. J Clin Oncol 19: 1830-1838 (Pubitemid 32230886)
43. Shimizu M, Fukutomi Y, Ninomiya M, Nagura K, Kato T, Araki H, Suganuma M, Fujiki H, Moriwaki H (2008) Green tea extracts for the prevention of metachronous colorectal adenomas: a pilot study. Cancer Epidemiol Biomarkers Prev 17:3020-3025
44. Shimizu M, Adachi S, Masuda M, Kozawa O, Moriwaki H (2011) Cancer chemoprevention with green tea catechins by targeting receptor tyrosine kinases. Mol Nutr Food Res 55:832-843
45. Sporn MB, Dunlop NM, Newton DL, Smith JM (1976) Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Fed Proc 35:1332-1338
46. Stingl JC, Ettrich T, Muche R, Wiedom M, Brockmöller J, Seeringer A, Seufferlein T (2011) Protocol for minimizing the risk of metachronous adenomas of the colorectum with green tea extract (MIRACLE): a randomized controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population. BMC Cancer 11:360
47. Sueoka N, Suganuma M, Sueoka E, Okabe S, Matsuyama S, Imai K, Nakachi K, Fujiki H (2001) A new function of green tea: prevention of lifestyle-related diseases. Ann N Y Acad Sci 928:274-280 (Pubitemid 32386088)
48. Suganuma M, Fujiki H, Suguri H, Yoshizawa S, Hirota M, Nakayasu M, Ojika M, Wakamatsu K, Yamada K, Sugimura T (1988) Okadaic acid: an additional non-phorbol-12-tetradecanoate-13- acetate-type tumor promoter. Proc Natl Acad Sci USA 85: 1768-1771 (Pubitemid 24315763)
49. Suganuma M, Okabe S, Oniyama M, Tada Y, Ito H, Fujiki H (1998) Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue. Carcinogenesis 19:1771-1776 (Pubitemid 28476352)
50. Suganuma M, Okabe S, Kai Y, Sueoka N, Sueoka E, Fujiki H (1999a) Synergistic effects of (-)-epigallocatechin gallate with (-)- epicatechin, sulindac, or tamoxifen on cancer-preventive activity in the human lung cancer cell line PC-9. Cancer Res 59:44-47 (Pubitemid 29062952)
51. Suganuma M, Okabe S, Marino MW, Sakai A, Sueoka E, Fujiki H (1999b) Essential role of tumor necrosis factor a (TNF-a) in tumor promotion as revealed by TNF-a-deficient mice. Cancer Res 59:4516-4518 (Pubitemid 29428949)
52. Suganuma M, Ohkura Y, Okabe S, Fujiki H (2001) Combination cancer chemoprevention with green tea extract and sulindac shown in intestinal tumor formation in Min mice. J Cancer Res Clin Oncol 127:69-72
53. Suganuma M, Okabe S, Kurusu M, Iida N, Ohshima S, Saeki Y, Kishimoto T, Fujiki H (2002) Discrete roles of cytokines, TNFa, IL-1, IL-6 in tumor promotion and cell transformation. Int J Oncol 20:131-136
54. Suganuma M, Kurusu M, Suzuki K, Tasaki E, Fujiki H (2006) Green tea polyphenol stimulates cancer preventive effects of celecoxib in human lung cancer cells by upregulation of GADD153 gene. Int J Cancer 119:33-40
55. Suganuma M, Saha A, Fujiki H (2011) New cancer treatment strategy using combination of green tea catechins and anticancer drugs. Cancer Sci 102:317-323
56. Taniguchi S, Fujiki H, Kobayashi H, Go H, Miyado K, Sadano H, Shimokawa R (1992) Effect of (-)-epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines. Cancer Lett 65:51-54
57. Tsao AS, Liu D, Martin J, Tang X-m, Lee JJ, El-Naggar AK, Wistuba I, Culotta KS, Mao L, Gillenwater A, Sagesaka YM, Hong WK, Papadimitrakopoulou V (2009) Phase II randomized, placebocontrolled trial of green tea extract in patients with high-risk oral premalignant lesions. Cancer Rev Res 2:931-941
58. Tsubono Y, Nishino Y, Komatsu S, Hsieh C-C, Kanemura S, Tsuji I, Nakatsuka H, Fukao A, Satoh H, Hisamichi S (2001) Green tea and the risk of gastric cancer in Japan. N Engl J Med 344:632-636 (Pubitemid 32183578)
59. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smith AMM, Bos JL (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319:525-532
60. Wang ZY, Hong JY, Huang MT, Reuhl K, Conney AH, Yang CS (1992) Inhibition of N-nitrosodiethylamine- and 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone- induced tumorigenesis in A/J mice by green tea and black tea. Cancer Res 52:1943-1947
61. Yamane T, Hagiwara N, Tateishi M, Akachi S, Kim M, Okuzumi J, Kitao Y, Inagake M, Kuwata K, Takahashi T (1991) Inhibition of azoxymethane-induced colon carcinogenesis in rat by green tea polyphenol fraction. Jpn J Cancer Res 82:1336-1339
62. Yamane T, Takahashi T, Kuwata K, Oya K, Inagake M, Kitao Y, Suganuma M, Fujiki H (1995) Inhibition of N-methyl-N'-nitro-Nnitrosoguanidine- induced carcinogenesis by (-)-epigallocatechin gallate in the rat glandular stomach. Cancer Res 55:2081-2084
63. Yang CS, Wang ZY (1993) Tea and cancer. J Natl Cancer Inst 85: 1038-1049 (Pubitemid 23199184)
64. Yang GY, Liao J, Kim K, Yurkow EJ, Yang CS (1998) Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols. Carcinogenesis 19:611-616 (Pubitemid 28376804)
65. Yoshizawa S, Horiuchi T, Fujiki H, Yoshida T, Okuda T, Sugimura T (1987) Antitumor promoting activity of (-)-epigallocatechin gallate, the main constituent of ''tannin'' in green tea. Phytother Res 1:44-47
66. Yoshizawa S, Horiuchi T, Suganuma M, Nishiwaki S, Yatsunami J, Okabe S, Okuda T, Muto Y, Frenkel K, Troll W, Fujiki H (1992) Penta-O-galloyl-b-D-glucose and (-)-epigallocatechin gallate. Am Chem Soc:316-325