Cryptotanshinone induces cell cycle arrest and apoptosis of multidrug resistant human chronic myeloid leukemia cells by inhibiting the activity of eukaryotic initiation factor 4E

Molecular and Cellular Biochemistry

Volumn 368, Issue 1-2, 2012, Pages 17-25

  Ge, Yuqing ^a   Cheng, Rubin ^a   Zhou, Yuhong ^a   Shen, Jianping ^a   Peng, Laijun ^a   Xu, Xiaofeng ^a   Dai, Qun ^a   Liu, Pei ^a   Wang, Haibing ^a   Ma, Xiaoqiong ^a   Jia, Jia ^b   Chen, Zhe ^a  

^a ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle arrest; Chronic myeloid leukemia; Cryptotanshinone; E IF4E

Indexed keywords

CRYPTOTANSHINONE; CYCLIN D1; INITIATION FACTOR 4E; PROTEIN BCL 2;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PROTEIN EXPRESSION; PROTEIN PROCESSING;

APOPTOSIS; CELL CYCLE CHECKPOINTS; CYCLIN D1; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; EUKARYOTIC INITIATION FACTOR-4E; GENE EXPRESSION REGULATION, LEUKEMIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PHENANTHRENES; PROTO-ONCOGENE PROTEINS C-BCL-2;

EUKARYOTA; SALVIA MILTIORRHIZA;

EID: 84864351010     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-012-1338-3     Document Type: Article

References (36)

1. Nowell PC, Hungerford DA (1960) Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst 25:85-109
2. Rowley JD (1973) Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 243: 290-293
3. Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM, Capdeville R, Talpaz M (2001) Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 344:1038-1042 (Pubitemid 32267973)
4. Hochhaus A, La Rosée P (2004) Imatinib therapy in chronic myelogenous leukemia: strategies to avoid and overcome resis-tance. Leukemia 18:1321-1331 (Pubitemid 39136739)
5. Konig H, Holyoake TL, Bhatia R (2008) Effective and selective inhibition of chronic myeloid leukemia primitive hematopoietic progenitors by the dual Src/Abl kinase inhibitor SKI-606. Blood 111:2329-2338 (Pubitemid 351451441)
6. Richter JD, Sonenberg N (2005) Regulation of cap-dependent translation by e IF4E inhibitory proteins. Nature 433:477-480 (Pubitemid 40204297)
7. Rousseau D, Kaspar R, Rosenwald I, Gehrke L, Sonenberg N (1996) Translation initiation of ornithine decarboxylase and nu-cleocytoplasmic transport of cyclin D1 m RNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc Natl Acad Sci USA 93:1065-1070 (Pubitemid 26054368)
8. De Benedetti A, Joshi B, Graff JR, Zimmer SG (1994) CHO cells transformed by the translation factor e IF4E display increased c-myc expression, but require overexpression of Max for tumorigenicity. Mol Cell Differ 2:347-371
9. Soni A, Akcakanat A, Singh G, Luyimbazi D, Zheng Y, Kim D, Gonzalez-Angulo A, Meric-Bernstam F (2008) e IF4E knock-down decreases breast cancer cell growth without activating Akt signaling. Mol Cancer Ther 7:1782-1788
10. Graff JR, Konicek BW, Lynch RL et al (2009) e IF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival. Cancer Res 69:3866-3873
11. Zimmer SG, De Benedetti A, Graff JR (2000) Translational con-trol of malignancy: the m RNA cap-binding protein, e IF-4E, as a central regulator of tumor formation, growth, invasion and metastasis. Anticancer Res 20:1343-1351 (Pubitemid 30628136)
12. Wendel HG, De Stanchina E, Fridman JS, Malina A, Ray S, Kogan S, Cordon-Cardo C, Pelletier J, Lowe SW (2004) Survival signalling by Akt and e IF4E in oncogenesis and cancer therapy. Nature 428:332-337 (Pubitemid 38418805)
13. Graff JR, Konicek BW, Vincent TM et al (2007) Therapeutic suppression of translation initiation factor e IF4E expression reduces tumor growth without toxicity. J Clin Invest 117:2638-2648 (Pubitemid 47494364)
14. Graff JR, Konicek BW, Carter JH, Marcusson EG (2008) Tar-geting the eukaryotic translation initiation factor 4E for cancer therapy. Cancer Res 68:631-634 (Pubitemid 351206735)
15. Ge Y, Zhou F, Chen H, Cui C, Liu D, Li Q, Yang Z, Wu G, Sun S, Gu J, Wei Y, Jiang J (2010) Sox2 is translationally activated by eukaryotic initiation factor 4E in human glioma-initiating cells. Biochem Biophys Res Commun 397:711-717
16. Thumma SC, Kratzke RA (2007) Translational control: a target for cancer therapy. Cancer Lett 258:1-8 (Pubitemid 47600498)
17. Kang BY, Chung SW, Kim SH, Ryu SY, Kim TS (2000) Inhi-bition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from Salvia miltiorrhiza. Immu-nopharmacology 49:355-361
18. Hur JM, Shim JS, Jung HJ, Kwon HJ (2005) Cryptotanshinone but not tanshinone IIA inhibits angiogenesis in vitro. Exp Mol Med 37:133-137 (Pubitemid 40676923)
19. Chen L, Zheng SZ, Sun ZG, Wang AY, Huang CH, Punchard NA, Huang SL, Gao X, Lu Y (2010) Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity. Cancer Chemother Pharmacol 68:17-27
20. Chen W, Luo Y, Liu L, Zhou H, Xu B, Han X, Shen T, Liu Z, Lu Y, Huang S (2010) Cryptotanshinone inhibits cancer cell prolif-eration by suppressing mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation. Cancer Prev Res (Phila) 3:1015-1025
21. Don MJ, Liao JF, Lin LY, Chiou WF (2007) Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of the PI3K signaling pathway. Br J Pharmacol 151:638-646
22. Shin DS, Kim HN, Shin KD, Yoon YJ, Kim SJ, Han DC, Kwon BM (2009) Cryptotanshinone inhibits constitutive signal trans-ducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res 69:193-202
23. Tsuruo T, Iida-Saito H, Kawabata H, Oh-hara T, Hamada H, Utakoji T (1986) Characteristics of resistance to adriamycin in human myelogenous leukemia K562 resistant to adriamycin and in isolated clones. Jpn J Cancer Res 77:682-692 (Pubitemid 16072385)
24. Topisirovic I, Guzman ML, Mc Connell MJ, Licht JD, Culjkovic B, Neering SJ, Jordan CT, Borden KL (2003) Aberrant eukaryotic translation initiation factor 4E-dependent m RNA transport impedes hematopoietic differentiation and contributes to leuke-mogenesis. Mol Cell Biol 23:8992-9002 (Pubitemid 37499790)
25. Cheng RB, Ma RJ, Wang ZK, Yang SJ, Lin XZ, Rong H, Ma Y (2011) PTEN status is related to cell proliferation and self-renewal independent of CD133 phenotype in the glioma-initiating cells. Mol Cell Biochem 349:149-157
26. Culjkovic B, Topisirovic I, Skrabanek L, Ruiz-Gutierrez M, Borden KL (2005) e IF4E promotes nuclear export of cyclin D1 m RNAs via an element in the 3'UTR. J Cell Biol 169:245-256 (Pubitemid 40656563)
27. Dean M, Hamon Y, Chimini G (2001) The human ATP-binding cassette (ABC) transporter superfamily. J Lipid Res 42:1007-1017 (Pubitemid 32645780)
28. Yan F, Jiang Y, Li YM, Zhen X, Cen J, Fang WR (2008) Reversal of P-glycoprotein and multidrug resistance-associated protein 1 mediated multidrug resistance in cancer cells by HZ08 isomers, tetrataisohydroquinolin derivatives. Biol Pharm Bull 31:1258-1264 (Pubitemid 351871172)
29. Malumbres M, Barbacid M (2009) Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 9:153-166
30. Musgrove EA (2006) Cyclins: roles in mitogenic signaling and oncogenic transformation. Growth Factors 24:13-19 (Pubitemid 43108773)
31. Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR (2010) The BCL-2 family reunion. Mol Cell 37:299-310
32. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP, Wang X (1997) Prevention of apoptosis by Bcl-2: release of cytochrome c frommitochondriablocked. Science 275:1129-1132 (Pubitemid 27097312)
33. Li S, Perlman DM, Peterson MS, Burrichter D, Avdulov S, Polunovsky VA, Bitterman PB (2004) Translation initiation factor 4E blocks endoplasmic reticulum-mediated apoptosis. J Biol Chem 279:21312-21317 (Pubitemid 38656538)
34. Prabhu S, Saadat D, Zhang M, Halbur L, Fruehauf JP, Ong ST (2007) A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the e IF4F translation initiation complex and m RNA translation. Oncogene 26:1188-1200
35. Assouline S, Culjkovic B, Cocolakis E, Rousseau C, Beslu N, Amri A, Caplan S, Leber B, Roy DC, Miller WH Jr, Borden KL (2009) Molecular targeting of the oncogene e IF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin. Blood 114:257-260
36. Borden KL, Culjkovic-Kraljacic B (2010) Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond? Leuk Lymphoma 51:1805-1815