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Volumn 138, Issue 6, 2012, Pages 907-916

Combination of temsirolimus and tyrosine kinase inhibitors in renal carcinoma and endothelial cell lines

Author keywords

Angiogenesis; Anti angiogenic drugs; Clear cell renal cell carcinoma; Combinations

Indexed keywords

SORAFENIB; SUNITINIB; TEMSIROLIMUS; VASCULOTROPIN;

EID: 84864345057     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-012-1162-x     Document Type: Article
Times cited : (9)

References (45)
  • 1
    • 40349108627 scopus 로고    scopus 로고
    • Inhibition of mTOR pathway by Everolimus cooperates with EGFR inhibitors in human tumours sensitive and resistant to anti-EGFR drugs
    • doi:10.1038/sj.bjc.6604269
    • Bianco R, Garofalo S, Rosa R, Damiano V, Gelardi T, Daniele G, Marciano R, Ciardiello F, Tortora G (2008) Inhibition of mTOR pathway by Everolimus cooperates with EGFR inhibitors in human tumours sensitive and resistant to anti-EGFR drugs. Br J Cancer 98:923-930. doi:10.1038/sj.bjc.6604269
    • (2008) Br J Cancer , vol.98 , pp. 923-930
    • Bianco, R.1    Garofalo, S.2    Rosa, R.3    Damiano, V.4    Gelardi, T.5    Daniele, G.6    Marciano, R.7    Ciardiello, F.8    Tortora, G.9
  • 2
    • 9144233506 scopus 로고    scopus 로고
    • Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells
    • Boulay A, Zumstein-Mecker S, Stephan C, Beuvink I, Zilbermann F, Haller R, Tobler S, Heusser C, O'Reilly T, Stolz B et al (2004) Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells. Cancer Res 64:252-261
    • (2004) Cancer Res , vol.64 , pp. 252-261
    • Boulay, A.1    Zumstein-Mecker, S.2    Stephan, C.3    Beuvink, I.4    Zilbermann, F.5    Haller, R.6    Tobler, S.7    Heusser, C.8    O'Reilly, T.9    Stolz, B.10
  • 3
    • 48649098245 scopus 로고    scopus 로고
    • Von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma
    • Choueiri TK, Vaziri SAJ, Jaeger E, Elson P, Wood L, Bhalla IP, Small EJ, Weinberg V, Sein N, Simko J et al (2008) von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma. J Urol 180:860-866
    • (2008) J Urol , vol.180 , pp. 860-866
    • Choueiri, T.K.1    Vaziri, S.A.J.2    Jaeger, E.3    Elson, P.4    Wood, L.5    Bhalla, I.P.6    Small, E.J.7    Weinberg, V.8    Sein, N.9    Simko, J.10
  • 6
    • 34547779489 scopus 로고    scopus 로고
    • Circulating protein biomarkers of pharmacodynamic activity of Sunitinib in patients with metastatic renal cell carcinoma: Modulation of VEGF and VEGFrelated proteins
    • doi:10.1186/1479-5876-5-32
    • DePrimo SE, Bello CL, Smeraglia J, Baum CM, Spinella D, Rini BI, Michaelson MD, Motzer RJ (2007) Circulating protein biomarkers of pharmacodynamic activity of Sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGFrelated proteins. J Transl Med 5:32. doi:10.1186/1479-5876-5-32
    • (2007) J Transl Med , vol.5 , pp. 32
    • Deprimo, S.E.1    Bello, C.L.2    Smeraglia, J.3    Baum, C.M.4    Spinella, D.5    Rini, B.I.6    Michaelson, M.D.7    Motzer, R.J.8
  • 8
    • 33644847440 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
    • doi:10.1200/JCO.2005.02.2194
    • Faivre S (2006) Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol 24:25-35. doi:10.1200/JCO.2005.02.2194
    • (2006) J Clin Oncol , vol.24 , pp. 25-35
    • Faivre, S.1
  • 9
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • doi:10.1038/nm0603-669
    • Ferrara N, Gerber H-P, LeCouter J (2003) The biology of VEGF and its receptors. Nat Med 9:669-676. doi:10.1038/nm0603-669
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.-P.2    Lecouter, J.3
  • 13
    • 77951877765 scopus 로고    scopus 로고
    • Alterations in VHL as potential biomarkers in renal-cell carcinoma
    • doi:10.1038/nrclinonc.2010.42
    • Gossage L, Eisen T (2010) Alterations in VHL as potential biomarkers in renal-cell carcinoma. Nat Rev Clin Oncol 7:277-288. doi:10.1038/nrclinonc.2010. 42
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 277-288
    • Gossage, L.1    Eisen, T.2
  • 17
    • 0029090338 scopus 로고
    • Tumour suppression by the human von Hippel-Lindau gene product
    • Iliopoulos O, Kibel A, Gray S, Kaelin WG Jr (1995) Tumour suppression by the human von Hippel-Lindau gene product. Nat Med 1:822-826
    • (1995) Nat Med , vol.1 , pp. 822-826
    • Iliopoulos, O.1    Kibel, A.2    Gray, S.3    Kaelin Jr., W.G.4
  • 18
    • 77955635233 scopus 로고    scopus 로고
    • Cancer statistics, 2010
    • doi:10.3322/caac.20073
    • Jemal A, Siegel R, Xu J, Ward E (2010) Cancer statistics, 2010. CA Cancer J Clin 60:277-300. doi:10.3322/caac.20073
    • (2010) CA Cancer J Clin , vol.60 , pp. 277-300
    • Jemal, A.1    Siegel, R.2    Xu, J.3    Ward, E.4
  • 19
    • 68549096316 scopus 로고    scopus 로고
    • Targeted inhibition of mammalian target of rapamycin for the treatment of advanced renal cell carcinoma
    • Kapoor A, Figlin RA (2009) Targeted inhibition of mammalian target of rapamycin for the treatment of advanced renal cell carcinoma. Cancer 115:3618-3630
    • (2009) Cancer , vol.115 , pp. 3618-3630
    • Kapoor, A.1    Figlin, R.A.2
  • 20
    • 50249108414 scopus 로고    scopus 로고
    • Classification of renal cell carcinoma based on expression of VEGF and VEGF receptors in both tumor cells and endothelial cells
    • doi:10.1038/labinvest.2008.65
    • Kluger HM, Siddiqui SF, Angeletti C, Sznol M, Kelly WK, Molinaro AM, Camp RL (2008) Classification of renal cell carcinoma based on expression of VEGF and VEGF receptors in both tumor cells and endothelial cells. Lab Investig J Tech Methods Pathol 88:962-972. doi:10.1038/labinvest.2008.65
    • (2008) Lab Investig J Tech Methods Pathol , vol.88 , pp. 962-972
    • Kluger, H.M.1    Siddiqui, S.F.2    Angeletti, C.3    Sznol, M.4    Kelly, W.K.5    Molinaro, A.M.6    Camp, R.L.7
  • 21
    • 53849125004 scopus 로고    scopus 로고
    • MTORC1 inhibitors: Is Temsirolimus in renal cancer telling us how they really work?
    • doi:10.1038/sj.bjc. 6604636
    • Le Tourneau C, Faivre S, Serova M, Raymond E (2008) mTORC1 inhibitors: is Temsirolimus in renal cancer telling us how they really work? Br J Cancer 99:1197-1203. doi:10.1038/sj.bjc. 6604636
    • (2008) Br J Cancer , vol.99 , pp. 1197-1203
    • Le Tourneau, C.1    Faivre, S.2    Serova, M.3    Raymond, E.4
  • 22
    • 33846212284 scopus 로고    scopus 로고
    • Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
    • Liu L, Cao Y, Chen C, Zhang X, McNabola A, Wilkie D, Wilhelm S, Lynch M, Carter C (2006) Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 66:11851-11858
    • (2006) Cancer Res , vol.66 , pp. 11851-11858
    • Liu, L.1    Cao, Y.2    Chen, C.3    Zhang, X.4    McNabola, A.5    Wilkie, D.6    Wilhelm, S.7    Lynch, M.8    Carter, C.9
  • 23
    • 0023890616 scopus 로고
    • Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix
    • Madri JA, Pratt BM, Tucker AM (1988) Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix. J Cell Biol 106:1375-1384
    • (1988) J Cell Biol , vol.106 , pp. 1375-1384
    • Madri, J.A.1    Pratt, B.M.2    Tucker, A.M.3
  • 26
    • 1542426623 scopus 로고    scopus 로고
    • Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor
    • doi:10.1038/sj.onc.1207268
    • Morimoto AM, Tan N, West K, McArthur G, Toner GC, Manning WC, Smolich BD, Cherrington JM (2004) Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor. Oncogene 23:1618-1626. doi:10.1038/sj.onc.1207268
    • (2004) Oncogene , vol.23 , pp. 1618-1626
    • Morimoto, A.M.1    Tan, N.2    West, K.3    McArthur, G.4    Toner, G.C.5    Manning, W.C.6    Smolich, B.D.7    Cherrington, J.M.8
  • 29
    • 79959549917 scopus 로고    scopus 로고
    • Temsirolimus and bevacizumab, or Sunitinib, or interferon alfa and bevacizumab for patients with advanced renal cell carcinoma (TORAVA): A randomised phase 2 trial
    • Négrier S, Gravis G, Pérol D, Chevreau C, Delva R, Bay JO, Blanc E, Ferlay C, Geoffrois L, Rolland F et al (2011) Temsirolimus and bevacizumab, or Sunitinib, or interferon alfa and bevacizumab for patients with advanced renal cell carcinoma (TORAVA): a randomised phase 2 trial. Lancet Oncol 12:673-680
    • (2011) Lancet Oncol , vol.12 , pp. 673-680
    • Négrier, S.1    Gravis, G.2    Pérol, D.3    Chevreau, C.4    Delva, R.5    Bay, J.O.6    Blanc, E.7    Ferlay, C.8    Geoffrois, L.9    Rolland, F.10
  • 30
    • 12444297983 scopus 로고    scopus 로고
    • The receptor tyrosine kinase inhibitor SU11248 impedes endothelial cell migration, tubule formation, and blood vessel formation in vivo, but has little effect on existing tumor vessels
    • Osusky KL, Hallahan DE, Fu A, Ye F, Shyr Y, Geng L (2004) The receptor tyrosine kinase inhibitor SU11248 impedes endothelial cell migration, tubule formation, and blood vessel formation in vivo, but has little effect on existing tumor vessels. Angiogenesis 7:225-233
    • (2004) Angiogenesis , vol.7 , pp. 225-233
    • Osusky, K.L.1    Hallahan, D.E.2    Fu, A.3    Ye, F.4    Shyr, Y.5    Geng, L.6
  • 31
    • 70349968211 scopus 로고    scopus 로고
    • Absence of VHL gene alteration and high VEGF expression are associated with tumour aggressiveness and poor survival of renal-cell carcinoma
    • doi:10.1038/sj.bjc.6605298
    • Patard J-J, Rioux-Leclercq N, Masson D, Zerrouki S, Jouan F, Collet N, Dubourg C, Lobel B, Denis M, Fergelot P (2009) Absence of VHL gene alteration and high VEGF expression are associated with tumour aggressiveness and poor survival of renal-cell carcinoma. Br J Cancer 101:1417-1424. doi:10.1038/sj.bjc.6605298
    • (2009) Br J Cancer , vol.101 , pp. 1417-1424
    • Patard, J.-J.1    Rioux-Leclercq, N.2    Masson, D.3    Zerrouki, S.4    Jouan, F.5    Collet, N.6    Dubourg, C.7    Lobel, B.8    Denis, M.9    Fergelot, P.10
  • 32
    • 65249102843 scopus 로고    scopus 로고
    • Phase i study combining treatment with Temsirolimus and Sunitinib malate in patients with advanced renal cell carcinoma
    • doi:10.3816/CGC.2009.n.004
    • Patel PH, Senico PL, Curiel RE, Motzer RJ (2009) Phase I study combining treatment with Temsirolimus and Sunitinib malate in patients with advanced renal cell carcinoma. Clin Genitourin Cancer 7:24-27. doi:10.3816/CGC.2009.n.004
    • (2009) Clin Genitourin Cancer , vol.7 , pp. 24-27
    • Patel, P.H.1    Senico, P.L.2    Curiel, R.E.3    Motzer, R.J.4
  • 33
    • 36849031075 scopus 로고    scopus 로고
    • A phase I, pharmacokinetic and pharmacodynamic study of Sorafenib (S), a multi-targeted kinase inhibitor in combination with Temsirolimus (T), an mTOR inhibitor in patients with advanced solid malignancies
    • [Abstract]
    • Patnaik A (2007) A phase I, pharmacokinetic and pharmacodynamic study of Sorafenib (S), a multi-targeted kinase inhibitor in combination with Temsirolimus (T), an mTOR inhibitor in patients with advanced solid malignancies. J Clin Oncol 25:3512 [Abstract]
    • (2007) J Clin Oncol , vol.25 , pp. 3512
    • Patnaik, A.1
  • 35
    • 2942735384 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
    • doi:10.1200/JCO.2004.08.116
    • Raymond E (2004) Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol 22:2336-2347. doi:10.1200/JCO.2004.08.116
    • (2004) J Clin Oncol , vol.22 , pp. 2336-2347
    • Raymond, E.1
  • 36
    • 33748526494 scopus 로고    scopus 로고
    • Clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: Impact of patient characteristics and von Hippel- Lindau gene status
    • Rini BI, Jaeger E, Weinberg V, Sein N, Chew K, Fong K, Simko J, Small EJ, Waldman FM (2006) Clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: impact of patient characteristics and von Hippel- Lindau gene status. BJU Int 98:756-762
    • (2006) BJU Int , vol.98 , pp. 756-762
    • Rini, B.I.1    Jaeger, E.2    Weinberg, V.3    Sein, N.4    Chew, K.5    Fong, K.6    Simko, J.7    Small, E.J.8    Waldman, F.M.9
  • 38
    • 33747819801 scopus 로고    scopus 로고
    • MTOR and cancer: Insights into a complex relationship
    • doi:10.1038/nrc1974
    • Sabatini DM (2006) mTOR and cancer: insights into a complex relationship. Nat Rev Cancer 6:729-734. doi:10.1038/nrc1974
    • (2006) Nat Rev Cancer , vol.6 , pp. 729-734
    • Sabatini, D.M.1
  • 39
    • 63049093979 scopus 로고    scopus 로고
    • From theoretical synergy to clinical supra-additive toxicity
    • Soria JC, Massard C, Izzedine H (2009) From theoretical synergy to clinical supra-additive toxicity. J Clin Oncol 27:1359-1361
    • (2009) J Clin Oncol , vol.27 , pp. 1359-1361
    • Soria, J.C.1    Massard, C.2    Izzedine, H.3
  • 40
    • 65949118243 scopus 로고    scopus 로고
    • Combination targeted therapy in advanced renal cell carcinoma
    • Sosman J, Puzanov I (2009) Combination targeted therapy in advanced renal cell carcinoma. Cancer 115:2368-2375
    • (2009) Cancer , vol.115 , pp. 2368-2375
    • Sosman, J.1    Puzanov, I.2
  • 41
    • 33846878944 scopus 로고    scopus 로고
    • Opportunities and obstacles to combination targeted therapy in renal cell cancer
    • Sosman JA, Puzanov I, Atkins MB (2007) Opportunities and obstacles to combination targeted therapy in renal cell cancer. Clin Cancer Res 13:764s-769s
    • (2007) Clin Cancer Res , vol.13
    • Sosman, J.A.1    Puzanov, I.2    Atkins, M.B.3
  • 42
    • 20044382799 scopus 로고    scopus 로고
    • Phase i clinical and pharmacokinetic study of the novel raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors
    • doi:10.1200/JCO.2005.06.124
    • Strumberg D (2004) Phase I clinical and pharmacokinetic study of the novel raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. J Clin Oncol 23:965-972. doi:10.1200/JCO.2005.06.124
    • (2004) J Clin Oncol , vol.23 , pp. 965-972
    • Strumberg, D.1
  • 44
    • 0034790016 scopus 로고    scopus 로고
    • MTOR, a novel target in breast cancer: The effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
    • Yu K, Toral-Barza L, Discafani C, Zhang WG, Skotnicki J, Frost P, Gibbons JJ (2001) mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr Relat Cancer 8:249-258
    • (2001) Endocr Relat Cancer , vol.8 , pp. 249-258
    • Yu, K.1    Toral-Barza, L.2    Discafani, C.3    Zhang, W.G.4    Skotnicki, J.5    Frost, P.6    Gibbons, J.J.7
  • 45
    • 79952671531 scopus 로고    scopus 로고
    • Inhibition of angiogenic and non-angiogenic targets by Sorafenib in renal cell carcinoma (RCC) in a RCC xenograft model
    • doi:10.1038/bjc.2011.55
    • Yuen JSP, Sim MY, Siml HG, Chong TW, Lau WKO, Cheng CWS, Huynh H (2011) Inhibition of angiogenic and non-angiogenic targets by Sorafenib in renal cell carcinoma (RCC) in a RCC xenograft model. Br J Cancer 104:941-947. doi:10.1038/bjc.2011.55
    • (2011) Br J Cancer , vol.104 , pp. 941-947
    • Yuen, J.S.P.1    Sim, M.Y.2    Siml, H.G.3    Chong, T.W.4    Lau, W.K.O.5    Cheng, C.W.S.6    Huynh, H.7


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