Humanized-Single Domain Antibodies (VH/VHH) that Bound Specifically to Naja kaouthia Phospholipase A2 and Neutralized the Enzymatic Activity

Toxins

Volumn 4, Issue 7, 2012, Pages 554-567

  Chavanayarn, Charnwit ^a   Thanongsaksrikul, Jeeraphong ^a   Thueng in, Kanyarat ^a   Bangphoomi, Kunan ^b   Sookrung, Nitat ^a   Chaicumpa, Wanpen ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

^b KASETSART UNIVERSITY   (Thailand)

Author keywords

Homology modeling; Molecular docking; Phospholipase A2 (PLA2); Single domain antibody (SdAb); Snake bite; Snake venom; VH VHH

Indexed keywords

PHOSPHOLIPASE A2; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SNAKE VENOM; SNAKE VENOM ANTISERUM;

ANTIBODY PRODUCTION; ARTICLE; BLEEDING; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ESCHERICHIA COLI; GENETIC TRANSFECTION; HEMOLYSIS; IMMUNOTHERAPY; LIPOLYSIS; MEMBRANE DAMAGE; MOLECULAR CLONING; MOLECULAR DOCKING; MUSCLE NECROSIS; NAJA; NAJA KAOUTHIA; NONHUMAN; PHAGE DISPLAY; PHAGEMID; SEQUENCE HOMOLOGY; SKIN NECROSIS; SNAKEBITE; TOXICITY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; CAMELS; CLONING, MOLECULAR; COBRA VENOMS; COMPLEMENTARITY DETERMINING REGIONS; ELAPIDAE; ESCHERICHIA COLI; HEMOLYSIS; HEMORRHAGE; HORSES; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; PHOSPHOLIPASES A2; PHOSPHOLIPIDS; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROTEIN CONFORMATION; SINGLE-DOMAIN ANTIBODIES;

EQUIDAE; NAJA KAOUTHIA;

EID: 84864332747     PISSN: 20726651     EISSN: None     Source Type: Journal    
DOI: 10.3390/toxins4070554     Document Type: Article

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