Enzymatic toxins from snake venom: Structural characterization and mechanism of catalysis

FEBS Journal

Volumn 278, Issue 23, 2011, Pages 4544-4576

  Kang, Tse Siang ^a   Georgieva, Dessislava ^b   Genov, Nikolay ^c   Murakami, Mário T ^d   Sinha, Mau ^e   Kumar, Ramasamy P ^e   Kaur, Punit ^e   Kumar, Sanjit ^e   Dey, Sharmistha ^e   Sharma, Sujata ^e   Vrielink, Alice ^f   Betzel, Christian ^b   Takeda, Soichi ^g   Arni, Raghuvir K ^h   Singh, Tej P ^e   Kini, R Manjunatha ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b UNIVERSITY OF HAMBURG   (Germany)

^c INSTITUTE OF ORGANIC CHEMISTRY   (Bulgaria)

^d BRAZILIAN CENTER FOR RESEARCH IN ENERGY AND MATERIALS CNPEM   (Brazil)

^e ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^f UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^g NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^h SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

acetylcholinesterase; l amino acid oxidase; metalloproteinase; phospholipase A 2; serine proteinase

Indexed keywords

ACETYLCHOLINESTERASE; AMINO ACID OXIDASE; ANTIINFLAMMATORY AGENT; BETA BUNGAROTOXIN; CROTOXIN; ELAIDOYLAMIDE; ENZYME PRECURSOR; LEVO AMINO ACID OXIDASE; METALLOPROTEINASE; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHOLIPASE A2; RUSSELLS VIPER VENOM FX ACTIVATOR; SERINE PROTEINASE; SNAKE VENOM; UNCLASSIFIED DRUG; VIPER VENOM; VIPEROTOXIN F; VIPOXIN;

BINDING AFFINITY; BINDING SITE; BIOCATALYSIS; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME GLYCOSYLATION; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; NEUROTOXICITY; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REVIEW; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THERMOSTABILITY; TOXIN ANALYSIS; TOXIN STRUCTURE; TOXIN SYNTHESIS;

ACETYLCHOLINESTERASE; ANIMALS; BIOCATALYSIS; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; ENZYME ACTIVATION; HUMANS; L-AMINO ACID OXIDASE; METALLOPROTEASES; MODELS, MOLECULAR; PHOSPHOLIPASES A2; PROTEIN CONFORMATION; SNAKE VENOMS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 81555214445     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08115.x     Document Type: Review

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