Structure of a cardiotoxic phospholipase A2 from Ophiophagus hannah with the "pancreatic loop"

Journal of Structural Biology

Volumn 138, Issue 3, 2002, Pages 207-215

  Zhang, Hai Long ^a   Xu, Su Juan ^a   Wang, Qiu Yan ^b   Song, Shi Ying ^a   Shu, Yu Yan ^b   Lin, Zheng Jiong ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Cardiotoxin; Crystal structure; King cobra phospholipase A2; Myotoxin

Indexed keywords

CARDIOTOXIN; OLIGOMER; PHOSPHOLIPASE A2; SNAKE VENOM;

ACIDITY; ARTICLE; CARDIOTOXICITY; CONFORMATION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; NONHUMAN; PANCREAS; PRIORITY JOURNAL; SNAKE; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; COBRA; CRYSTALLOGRAPHY, X-RAY; DIRECT LYTIC FACTORS; ELECTRONS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHOLIPASES A; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

OPHIOPHAGUS HANNAH;

EID: 0036419961     PISSN: 10478477     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1047-8477(02)00022-9     Document Type: Article

References (52)

1. Alape-Giron, A., Persson, B., Cederlund, E., Flores-Diaz, M., Gutierrez, J.M., Thelestam, M., Bergman, T., Jornvall, H., 1999. Elapid venom toxins: Multiple recruitments of ancient scaffolds. Eur. J. Biochem. 259, 225-234.
2. 2 - A structural review. Toxicon 34, 827-841.
3. 2. Toxicon 22, 743-758.
4. Bhaskaran, R.B., Huang, C.C., Chang, D.K., Yu, C., 1994. Cardiotoxin III from the Taiwan cobra (Naja naja atra): Determination of structure in solution and comparison with short neurotoxins. J. Mol. Biol. 235, 1291-1301.
5. 2-like precursor. Biochim. Biophys. Acta 1088, 401-408.
6. Brunger, A.T., 1992a. XPLOR Manual, Version 3.1, Yale University, New Haven, CT.
7. Brunger, A.T., 1992b. Free R value: A novel statistical quantity for assessing the accuracy of crystal structures. Nature 355, 472-475.
8. Brunger, A.T., Adams, P.D., Clore, G.M., DeLano, W.L., Gros, P., Grosse-Kunstleve, R.W., Jiang, J.S., Kuszewski, J., Nilges, M., Pannu, N.S., Read, R.J., Rice, L.M., Simonson, T., Warren, G.L., 1998. Crystallography and NMR System: A new software suite for macromolecular structure determination. Acta Crystallogr. Sect. D 54, 905-921.
9. 2 at 2.5Å: Access to a shielded catalytic center. J. Biol. Chem. 260, 9742-9749.
10. Chang, W.C., Lee, M.L., Lo, T.B., 1983. Phospholipase A2 activity of long-chain cardiotoxins in the venom of the banded krait (Bungarus fasciatus). Toxicon 21, 163-165.
11. 2 from the venom of Agkistrodon halys Pallas. Toxicon 25, 401-409.
12. 2 from snake venom to human secreted forms. J. Mol. Evol. 31, 228-238.
13. 2 at 1.7Å resolution. J. Mol. Biol. 147, 97-123.
14. 2. J. Mol. Biol. 168, 163-179.
15. 2, anticogulant myotoxic activities. Biochim. Biophys. Acta 1070, 455-460.
16. Dufourcq, J., Faucon, J.F., 1978. Specific binding of a cardiotoxin from Naja mossambica mossambica to charged phospholipids detected by intrinsic fluorescence. Biochemistry 17, 1170-1176.
17. 2 according to sequence: Evolutionary and pharmacological implications. Eur. J. Biochem. 137, 545-551.
18. Faucon, J.F., Dufourcq, J., Couraud, F., Rochat, H., 1979. Lipid-protein interactions: A comparative study of the binding of cardiotoxins and neurotoxins to phospholipid vesicles. Biochim. Biophys. Acta 554, 332-339.
19. Fletcher, J.E., Rapuano, B.E., Condrea, E., Yang, C.C., Rosenberg, P., 1981. Relationship between catalysis and toxicological properties of 3 phospholipases-A2 from elapid snake venoms. Toxicol. Appl. Pharmacol 59, 375-388.
20. 2 Enzymes: Structure, Function and Mechanism. Wiley, New York, pp. 455-497.
21. Fletcher, J.E., Yang, C.C., Rosenberg, P., 1982. Basic phospholipase A2 from Naja nigricollis snake venom: Phospholipid hydrolysis and effects on electrical and contractile activity of the rat heart. Toxicol. Appl. Pharmacol. 66, 39-54.
22. 2 from Indian cobra reveals a trimeric association. Proc. Natl. Acad. Sci. USA 90, 342-346.
23. Gao, R., Kini, R.M., Gopalakrishnakone, P., 1999. Purification, properties, and amino acid sequence of a hemoglobinuria-inducing phospholipase (A2), MiPLA-1, from Micropechis ikaheka venom. Arch. Biochem. Biophys. 369, 181-192.
24. 2 from the venom of Deinagkistrodon acutus. Acta Crystallogr. Sect. D 58, 104-110.
25. 2 from the venom of Naja naja kaouthia. Toxicon 40, in press.
26. 2 myotoxins from Bothrops snake venoms. Toxicon 33, 1405-1424.
27. 2 based upon structural determinants. J. Biol. Chem. 252, 4913-4921.
28. 2 of Ophiophagus Hannah venom from Fujian. Acta Biochem. Biophys. Sin. 23, 70-77.
29. 2 purified from Ophiophagus hannah (king cobra) venom on rat heart. Toxicon 31, 627-635.
30. 2 from the venom of Ophiophagus hannah (king cobra): A novel cobra venom enzyme with "pancreatic loop". Arch. Biochem. Biophys. 338, 150-156.
31. Jones, T.A., 1985. Diffraction methods for biological macromolecules. Methods Enzymol. 115, 157-171.
32. 2 Enzymes: Structure, Function and Mechanism. Wiley, New York, pp. 1-28.
33. 2 by deletion of a surface loop. Science 244, 82-85.
34. Kumer, T.K.S., Sivaraman, T., Yu, C., 2000. Probing the structure, function, dynamics and folding of snake venom cardiotoxins. In: Tu, A.T., Gaffield, W. (Eds.), Natural and Synthetic Toxins: Biological Implications. Oxford Univ. Press, London, pp. 222-248.
35. Laskowski, R., Macarthur, M., Moss, D., Thornton, J., 1993. Procheck: A program to check stereochemical quality of protein structures. J. Appl. Crystallogr. 26, 283-290.
36. Lee, C.Y., Hod, C.L., Eaker, D., 1977. Cardiotoxin-like action of a basic phospholipase A isolated from Naja nigricollis venom. Toxicon 15, 355-357.
37. Lin, Z.-J., Tang, L., Zhao, K.-H., Zhao, H.-Y., Wang, X.-Q., Meng, W.-Y., Gui, L.-L., Song, S.-Y., Chen, Y.-C., Zhou, Y.-C., 2000. In: Tu, A.T., GaQeld, W. (Eds.), Natural and Synthetic Toxins: Biological Implications. Oxford Univ. Press, London, pp. 249-261.
38. Liu, C.-S., Chen, J.-M., Chang, S.-W., Chen, S.-W., Tsai, I.-H., Lu, H.-S., Lo, T.-B., 1990. Revised amino acid sequences of the three major phospholipases A2 from Bungarus fasciatus (banded krait) venom. Toxicon 28, 1457-1468.
39. Matthews, B.W., 1968. Solvent content of protein crystals. J. Mol. Biol. 33, 491-497.
40. 2 on blood plasma and on a cell-free system is due to a phospholipid-independent mechanism of action involving the inhibition of factor Va. Eur. J. Biochem. 237, 778-785.
41. Navaza, J., 1994. AMoRe: An automated package for molecular replacement. Acta Crystallogr. Sect. A 50, 157-163.
42. Otwinowski, Z., Minor, W., 1997. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326.
43. Renetseder, R., Brunie, S., Dijkstra, B.W., Drenth, J., Sigler, P.B., 1985. A comparison of the crystal structures of phospholipase A2 from bovine pancreas and Crotalus atrox venom. J. Biol Chem. 260, 11627-11634.
44. 2+ reveal trimeric packing. J. Mol. Biol. 279, 223-232.
45. 2. Science 250, 1541-1546.
46. 2 from Trimeresurus flavoviridis (habu snake) venom at 1.5 Å resolution. J. Biochem. 117, 730-740.
47. 2 with enhanced activity at 2.1 Å resolution. J. Mol. Biol. 216, 425-439.
48. Vincent, J.P., Schweitz, H., Chicheportiche, R., Fosset, M., Balerna, M., Lenoir, M.C., Lazdunski, M., 1976. Molecular mechanism of cardiotoxin action on axonal membranes. Biochemistry 15, 3171-3175.
49. 2 from Guangxi Ophiophagus hannah (king cobra) Venom, M.S. thesis, Medical University, China.
50. 2 from venom of Ophiophagus hannah (king cobra), Guangxi species. Acta Biochim. Biophys. Sin. 33, 340-344.
51. 2 from Ophiophagus hannah (king cobra). Acta Crystallogr. Sect. D 57, 709-710.
52. 2 from Agkistrodon halys Pallas snake venom - Implications for its association and anticoagulant activities by X-ray crystallography. Toxicon 38, 901-916.