STAT3 mutations correlated with hyper-IgE syndrome lead to blockage of IL-6/STAT3 signalling pathway

Journal of Biosciences

Volumn 37, Issue 2, 2012, Pages 243-257

  He, Jianxin ^a   Shi, Jie ^a   Xu, Ximing ^a   Zhang, Wenhua ^a   Wang, Yuxin ^a   Chen, Xing ^a   Du, Yuping ^a   Zhu, Ning ^a   Zhang, Jing ^a   Wang, Qin ^a   Yang, Jinbo ^a,b  

^a LANZHOU UNIVERSITY   (China)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Hyper IgE syndrome; IL 6; Jak STAT3 signalling; STAT3 mutation

Indexed keywords

GLYCOPROTEIN GP 130; INTERLEUKIN 6; JANUS KINASE 2; PROTEIN SH2; STAT3 PROTEIN; TYROSINE;

DISEASE; DNA; GENOTYPE; MUTATION; PATHOGEN;

ARTICLE; CONTROLLED STUDY; DIMERIZATION; DNA BINDING; GENE; GENE CONTROL; GENE EXPRESSION PROFILING; GENE LOCATION; GENE TARGETING; HUMAN; HUMAN CELL; HYPER IGE SYNDROME; LOSS OF FUNCTION MUTATION; MUTATIONAL ANALYSIS; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STAT3 GENE; TRANSACTIVATION;

CELL LINE, TUMOR; DIMERIZATION; DNA; HETEROZYGOTE; HUMANS; INTERLEUKIN-6; JOB'S SYNDROME; MODELS, MOLECULAR; MUTATION; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; STAT3 TRANSCRIPTION FACTOR; TRANSFECTION;

EID: 84864326025     PISSN: 02505991     EISSN: 09737138     Source Type: Journal    
DOI: 10.1007/s12038-012-9202-x     Document Type: Article

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