c-Jun and c-Fos cooperate with STAT3 in IL-6-induced transactivation of the IL-6 response element (IRE)

Cytokine

Volumn 14, Issue 2, 2001, Pages 78-87

  Schuringa, Jan Jacob ^a,b   Timmer, Hilko ^a   Luttickhuizen, Daniël ^a   Vellenga, Edo ^b   Kruijer, Wiebe ^a  

^a University of Groningen Center of Biological Sciences Haren   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

c Fos; c Jun; IL 6; STAT3; Transactivation

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN C JUN; STAT3 PROTEIN; TRANSCRIPTION FACTOR AP 1;

ARTICLE; BINDING SITE; DIMERIZATION; DNA BINDING; DNA RESPONSIVE ELEMENT; ELECTROPHORETIC MOBILITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; ONCOGENE C FOS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION INITIATION;

EUKARYOTA;

EID: 0035925882     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.2001.0856     Document Type: Article

References (33)

1. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
2. The IL-6 signal transducer, gpl30: An oncostatin M receptor and affinity converter for the LIF receptor
3. Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6
4. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130
5. Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction
6. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
7. Eukaryotic transcriptional regulatory proteins
8. Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1
9. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
10. The regulation of AP-1 activity by mitogen-activated protein kinases
11. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
12. The serum response element
13. c-Jun is a JNK-independent coactivator of the PU.1 transcription factor
14. Smads bind directly to the Jun family of AP-1 transcription factors
15. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
16. Cooperative transcriptional activity of Jun and Star3 beta, a short form of Star3
17. Interacting regions in Star3 and c-Jun that participate in cooperative transcriptional activation
18. Stimulation of the human intercellular adhesion molecule-1 promoter by interleukin-6 and interferon-gamma involves binding of distinct factors to a palindromic response element
19. The enhanceosome and transcriptional synergy
20. Transcriptional regulation of the junB promoter: Analysis of STAT-mediated signal transduction
21. Coordinate regulation of choline acetyltransferase, tyrosine hydroxylase, and neuropeptide mRNAs by ciliary neurotrophic factor and leukemia inhibitory factor in cultured sympathetic neurons
22. Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements
23. Nuclear factors interacting with an interleukin-6 responsive element of rat alpha 2-macroglobulin gene
24. Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA
25. Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)
26. Rapid inhibition of interleukin-6 signaling and Star3 activation mediated by mitogen-activated protein kinases
27. The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130
28. Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components
29. Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer
30. Transfection of mamalian cells using calcium phosphate
31. Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines
32. Tissue-specific enhancer of the human glycoprotein hormone alpha-subunit gene: Dependence on cyclic AMP-inducible elements
33. Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors