Phthalate exposure during cold plastisol application-a human biomonitoring study

Toxicology Letters

Volumn 213, Issue 1, 2012, Pages 100-106

  Koch, Holger Martin ^a   Haller, Andreas ^b   Weiß, Tobias ^a   Käfferlein, Heiko Udo ^a   Stork, Joachim ^b   Brüning, Thomas ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b AUDI AG   (Germany)

Author keywords

Exposure; Human biomonitoring; Metabolites; Phthalates; Plastisol; Urine

Indexed keywords

BUTYL BENZYLPHTHALATE; DI ISO BUTYLPHTHALATE; DI N BUTYLPHTHALATE; MONO (CARBOXY ISOOCTYL)PHTHALATE; MONO (HYDROXYISONONYL)PHTHALATE; MONO (OXO ISONONYL)PHTHALATE; MONO ISONONYL PHTHALATE; MONO(2 ETHYL 5 CARBOXYPENTYL)PHTHALATE; MONO(2 ETHYL 5 HYDROXYHEXYL)PHTHALATE; MONO(2 ETHYL 5 OXOHEXYL)PHTHALATE; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PHTHALIC ACID DERIVATIVE; PHTHALIC ACID DICYCLOHEXYL ESTER; PHTHALIC ACID DIETHYL ESTER; PHTHALIC ACID DIISODECYL ESTER; PHTHALIC ACID DIISONONYL ESTER; PHTHALIC ACID DIMETHYL ESTER; PHTHALIC ACID DIPENTYL ESTER; PLASTISOL; POLYVINYLCHLORIDE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; AUTOMOBILE INDUSTRY; BIOLOGICAL MONITORING; CONTROLLED STUDY; GERMANY; HUMAN; HUMAN EXPERIMENT; KINETICS; MALE; METABOLITE; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; SHIFT WORKER; SKIN; URINALYSIS;

ADULT; AUTOMOBILES; DIETHYLHEXYL PHTHALATE; ENVIRONMENTAL MONITORING; HUMANS; INDUSTRY; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; PHTHALIC ACIDS;

EID: 84864308740     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.06.010     Document Type: Article

References (42)

1. Albro P.W., Moore B. Identification of the metabolites of simple phthalate diesters in rat urine. J. Chromatogr. 1974, 94:209-218.
2. Angerer J., Ewers U., Wilhelm M. Human biomonitoring: state of the art. Int. J. Hyg. Environ. Health 2007, 210:201-228.
3. Barr D.B., Silva M.J., Kato K., Reidy J.A., Malek N.A., Hurtz D., Sadowski M., Needham L.L., Calafat A.M. Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers. Environ. Health Perspect. 2003, 111:1148-1151.
4. Bizzari, S.N., Blagoev, M., Kishi, A., 2009.Plasticizers. SRI Consulting. Chemical Economics Handbook Marketing Research Report.
5. Boberg J., Christiansen S., Axelstad M., Kledal T.S., Vinggaard A.M., Dalgaard M., Nellemann C., Hass U. Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats. Reprod. Toxicol. 2011, 31:200-209.
6. Calafat A.M., Silva M.J., Reidy J.A., Earl G.L., Samandar E., Preau J.L., Herbert A.R., Needham L.L. Mono-(3-carboxypropyl) phthalate, a metabolite of di-n-octyl phthalate. J. Toxicol. Environ. Health A 2006, 69:215-227.
7. Calafat A.M., Wong L.Y., Silva M.J., Samandar E., Preau J.J., Jia L.T., Needham L.L. Selecting adequate exposure biomarkers of diisononyl and diisodecyl phthalates: data from the 2005-2006 National Health and Nutrition Examination Survey. Environ. Health Perspect. 2011, 119:50-55.
8. CDC, 2005.Third National Report on Human Exposure to Environmental Chemicals. (). Atlanta, GA, Centers for Disease Control and Prevention; National Center for Environmental Health; Division of Laboratory Sciences. 11-4-2007. http://www.cdc.gov/exposurereport/3rd/pdf/thirdreport.pdf.
9. Deutsche Forschungsgemeinschaft Di(2-ethylhexyl)phthalate (DEHP). Greim, H. 35. Gesundheitsschädliche Arbeitsstoffe-Toxikologisch-arbeitsmedizinische Begründungen von MAK-Werten. 2002, Wiley-VCH, Weinheim. Ergänzungslieferung (Ed.).
10. DFG Biological Monitoring - Prospects in Occupational and Environmental Medicine 2002, Wiley-VCH, Weinheim.
11. Dirven H.A., van den Broek P.H., Arends A.M., Nordkamp H.H., de Lepper A.J., Henderson P.T., Jongeneelen F.J. Metabolites of the plasticizer di(2-ethylhexyl)phthalate in urine samples of workers in polyvinylchloride processing industries. Int. Arch. Occup. Environ. Health 1993, 64:549-554.
12. Foster P.M. Mode of action: impaired fetal Leydig cell function - effects on male reproductive development produced by certain phthalate esters. Crit. Rev. Toxicol. 2005, 35:713-719.
13. Gaudin R., Marsan P., Ndaw S., Robert A., Ducos P. Biological monitoring of exposure to di(2-ethylhexyl) phthalate in six French factories: a field study. Int. Arch. Occup. Environ. Health 2010.
14. Gaudin R., Marsan P., Robert A., Ducos P., Pruvost A., Levi M., Bouscaillou P. Biological monitoring of occupational exposure to di(2-ethylhexyl) phthalate: survey of workers exposed to plastisols. Int. Arch. Occup. Environ. Health 2008, 81:959-966.
15. Gray E.L. Phthalates and Bisphenol A (BPA): Written Testimony before the House Energy & Commerce Committee; Commerce, Trade, and Consumer Protection Subcommittee 2008, United States House of Representatives.
16. Gray L.E., Ostby J., Furr J., Price M., Veeramachaneni D.N., Parks L. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol. Sci. 2000, 58:350-365.
17. Hannas, B.R., Lambright, C.S., Furr, J., Howdeshell, K.L., Wilson, V.S., Gray, L.E. Jr., (in press). Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate and diisononyl phthalate. Toxicol Sci. doi:10.1093/toxsci/kfr146.
18. Haufroid V., Lison D. Urinary cotinine as a tobacco-smoke exposure index: a minireview. Int. Arch. Occup. Environ. Health 1998, 71:162-168.
19. Heudorf U., Mersch-Sundermann V., Angerer J. Phthalates: toxicology and exposure. Int. J. Hyg. Environ. Health 2007, 210:623-634.
20. Hines C.J., Hopf N., Deddens J., Calafat A., Silva M., Grote A., Sammons D. Urinary phthalate metabolite concentrations among workers in selected industries. Epidemiology 2008, 19:S104.
21. Hines C.J., Hopf N.B., Deddens J.A., Silva M.J., Calafat A.M. Estimated daily intake of phthalates in occupationally exposed groups. J. Expo. Sci. Environ. Epidemiol. 2011, 21:133-141.
22. Hines C.J., Hopf N.B.N., Deddens J.A., Calafat A.M., Silva M.J., Grote A.A., Sammons D.L. Urinary phthalate metabolite concentrations among workers in selected industries: a pilot biomonitoring study. Ann. Occup. Hyg. 2009, 53:1-17.
23. Koch H.M., Angerer J. Di-iso-nonylphthalate (DINP) metabolites in human urine after a single oral dose of deuterium-labelled DINP. Int. J. Hyg. Environ. Health 2007, 210:9-19.
24. Koch H.M., Bolt H.M., Preuss R., Angerer J. New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP. Arch. Toxicol. 2005, 79:367-376.
25. Koch H.M., Calafat A.M. Human body burdens of chemicals used in plastic manufacture. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2009, 364:2063-2078.
26. Koch H.M., Gonzalez-Reche L.M., Angerer J. On-line clean-up by multidimensional liquid chromatography-electrospray ionization tandem mass spectrometry for high throughput quantification of primary and secondary phthalate metabolites in human urine. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 2003, 784:169-182.
27. Koch H.M., Muller J., Angerer J. Determination of secondary, oxidised di-iso-nonylphthalate (DINP) metabolites in human urine representative for the exposure to commercial DINP plasticizers. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 2007, 847:114-125.
28. Koch H.M., Rossbach B., Drexler H., Angerer J. Internal exposure of the general population to DEHP and other phthalates - determination of secondary and primary phthalate monoester metabolites in urine. Environ. Res. 2003, 93:177-185.
29. Pan G., Hanaoka T., Yoshimura M., Zhang S., Wang P., Tsukino H., Inoue K., Nakazawa H., Tsugane S., Takahashi K. Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a cross-sectional study in China. Environ. Health Perspect. 2006, 114:1643-1648.
30. Preau J.L., Wong L.Y., Silva M.J., Needham L.L., Calafat A.M. Variability over 1 week in the urinary concentrations of metabolites of diethyl phthalate and di(2-ethylhexyl) phthalate among eight adults: an observational study. Environ. Health Perspect. 2010, 118:1748-1754.
31. Riboli E., Prestonmartin S., Saracci R., Haley N.J., Trichopoulos D., Becher H., Burch J.D., Fontham E.T.H., Gao Y.T., Jindal S.K., Koo L.C., Lemarchand L., Segnan N., Shimizu H., Stanta G., Wuwilliams A.H., Zatonski W. Exposure of nonsmoking women to environmental tobacco-smoke - a 10-country collaborative study. Cancer Cause Control 1990, 1:243-252.
32. Rider C.V., Furr J., Wilson V.S., Gray L.E. A mixture of seven antiandrogens induces reproductive malformations in rats. Int. J. Androl. 2008, 31:249-262.
33. Sharpe R.M., Irvine D.S. How strong is the evidence of a link between environmental chemicals and adverse effects on human reproductive health?. Br. Med. J. 2004, 328:447-451.
34. Sharpe R.M., Skakkebaek N.E. Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects. Fertil. Steril. 2008, 89:e33-e38.
35. Silva M.J., Kato K., Gray E.L., Wolf C., Needham L.L., Calafat A.M. Urinary metabolites of di-n-octyl phthalate in rats. Toxicology 2005, 210:123-133.
36. Silva M.J., Kato K., Wolf C., Samandar E., Silva S.S., Gray E.L., Needham L.L., Calafat A.M. Urinary biomarkers of di-isononyl phthalate in rats. Toxicology 2006, 223:101-112.
37. Silva M.J., Samandar E., Reidy J.A., Hauser R., Needham L.L., Calafat A.M. Metabolite profiles of di-n-butyl phthalate in humans and rats. Environ. Sci. Technol. 2007, 41:7576-7580.
38. Tanaka A., Matsumoto A., Yamaha T. Biochemical studies on phthalic esters. III. Metabolism of dibutyl phthalate (DBP) in animals. Toxicology 1978, 9:109-123.
39. Taussky H.H. A microcolorimetric determination of creatine in urine by the Jaffe reaction. J. Biol. Chem. 1954, 208:853-861.
40. Wittassek M., Angerer J. Phthalates: metabolism and exposure. Int. J. Androl. 2008, 31:131-138.
41. Wittassek M., Koch H.M., Angerer J., Brüning T. Assessing exposure to phthalates - the human biomonitoring approach. Mol. Nutr. Food Res. 2011, 55:7-31.
42. Xu X., Iba M.M., Weisel C.P. Simultaneous and sensitive measurement of anabasine, nicotine, and nicotine metabolites in human urine by liquid chromatography-tandem mass spectrometry. Clin. Chem. 2004, 50:2323-2330.