Noninvasive real-time fluorescence imaging of the lymphatic uptake of BSA-IRDye 680 conjugate administered subcutaneously in mice

Journal of Pharmaceutical Sciences

Volumn 101, Issue 5, 2012, Pages 1744-1754

  Wu, Fang ^a   Bhansali, Suraj G ^a,b   Tamhane, Mitalee ^a   Kumar, Rajiv ^a   Vathy, Lisa A ^a   Ding, Hong ^a   Yong, Ken Tye ^a   Bergey, Earl J ^a   Prasad, Paras N ^a   Morris, Marilyn E ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Albumin; Imaging method; Lymphatic transport; Protein; Protein delivery

Indexed keywords

BOVINE SERUM ALBUMIN; BOVINE SERUM ALBUMIN INFRARED DYE 680 CONJUGATE; DYE; UNCLASSIFIED DRUG; FLUORESCENT DYE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AXILLARY LYMPH NODE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG UPTAKE; FLUORESCENCE IMAGING; FOOT PAD; GEL PERMEATION CHROMATOGRAPHY; HAIRLESS MOUSE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMOGENATE; INFRARED RADIATION; LYMPH NODE; LYMPHATIC UPTAKE; MALE; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; SIZE EXCLUSION HIGH PERFORMANCE LIQUID CHROMATOGRAPHY AND; TEMPERATURE; WHOLE BODY IMAGING; ANIMAL; CHEMISTRY; FLUORESCENCE; GEL CHROMATOGRAPHY; LYMPH VESSEL; METABOLISM; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLUORESCENCE; FLUORESCENT DYES; INJECTIONS, SUBCUTANEOUS; LYMPHATIC VESSELS; MICE; SERUM ALBUMIN, BOVINE;

EID: 84864299222     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23058     Document Type: Article

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