Dietary intake increases serum levels of carboxymethil-lysine (CML) in diabetic patients;La ingesta dietaria de carboximetil-lisina (CML) aumenta los niveles plasmáticos de este compuesto en pacientes diabéticos

Nutricion Hospitalaria

Volumn 27, Issue 4, 2012, Pages 1272-1278

  Jara, N ^a   Leal, M J ^a   Bunout, D ^a   Hirsch, S ^a   Barrera, G ^a   Leiva, L ^a   de la Maza, M P ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

Advanced glycation end products (AGEs); Carboxymethyl lysine (CML); Diabetes; Diet; Dietary intake

Indexed keywords

DRUG DERIVATIVE; LYSINE; N(6) CARBOXYMETHYLLYSINE; N(6)-CARBOXYMETHYLLYSINE;

ADULT; AGED; ANTHROPOMETRY; ARTICLE; BLOOD; BLOOD PRESSURE; BODY MASS; DAIRY PRODUCT; DIET; EATING; FEMALE; FOOD; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSIOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTHROPOMETRY; BLOOD PRESSURE; BODY MASS INDEX; DAIRY PRODUCTS; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DIET; EATING; FEMALE; FOOD; HUMANS; LYSINE; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 84864295014     PISSN: 02121611     EISSN: 16995198     Source Type: Journal    
DOI: 10.3305/nh.2012.27.4.5861     Document Type: Article

References (51)

1. Singh R, Barden A, Mori T, Beilin L, Advanced glycation end-products: a review. Diabetologia 2001; 44 (2): 129-146.
2. Vlassara H. Advanced glycation in health and disease: role of the modern environment. Ann N Y Acad Sci 2005; 1043: 452-460.
3. Bengmark CS. Advanced Fglycation Fand Flipoxidation Fend Fproducts-amplifiers Fof inflammation: the role of food. JPEN J Parenter Enteral Nutr 2007; 31 (5): 430-440.
4. Ames JM. Determination of N epsilon-(carboxymethyl)lysine in foods and related systems. Ann N Y Acad Sci 2008; 1126: 20-24.
5. Somoza V. Cive years of research on health risks and benefits of Maillard reaction products: an update. Mol Nutr Food Res 2005; 49 (7): 663-672.
6. Kankova K. Diabetic threesome (hyperglycaemia, renal function and nutrition) and advanced glycation end products: evidence for the multiple-hit agent? Proc Nutr Soc 2008; 67 (1): 60-74.
7. Coughlan MT, Mibus AL, Forbes JM. Oxidative stress and advanced glycation in diabetic nephropathy. Ann N Y Acad Sci 2008; 1126: 190-193.
8. Dyer DG, Dunn JA, Thorpe SR, Bailie KE, Lyons TJ, McCance DR, Baynes JW. Accumulation of Maillard reaction products in skin collagen in diabetes and aging. J Clin Invest 1993; 91 (6): 2463-2469.
9. Miranda I. Actividad citotoxica y antioxidante de los productos de la reaccion de Maillard de los sistemas modelo D-glucosa-glicina y D-glucosa-L-lisina. Revista de la Sociedad Quimica de Peru 2007; 73 (4): 215-225.
10. Rossi J. La combinacion de los azucares con las biomoleculas o como alimentarse en forma saludable. Medicina (Buenos Aires) 2007; 67: 161-166.
11. Ruiz B. Propiedades antioxidantes de los productos de la reac-cion de Maillard y su influencia en la absorcion de hierro y cobre. Reaccion con la capacidad quelante de metales., in Uni-dad de nutricion animal de la estacion experimental de Zaidin. 2009, Universidad de Granada: Granada, p. 461.
12. Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, Yong A, Striker GE, Vlassara H. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc 2010; 110 (6): 911-916 e12.
13. Koschinsky T, He CJ, Mitsuhashi T, Bucala R, Liu C, Buenting C, Heitmann K, Vlassara H. Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy. Proc Natl Acad Sci USA 1997; 94 (12): 6474-6479.
14. Uribarri J, Peppa M, Cai W, Goldberg T, Lu M, He C, Vlassara H. Restriction of dietary glycotoxins reduces excessive advanced glycation end products in renal failure patients. J Am Soc Nephrol 2003; 14 (3): 728-731.
15. Uribarri J, Stirban A, Sander D, Cai W, Negrean M, Buenting CE, Koschinsky T, Vlassara H. Single oral challenge by advanced glycation end products acutely impairs endothelial function in diabetic and nondiabetic subjects. Diabetes Care 2007; 30 (10): 2579-2582.
16. Uribarri J, Cai W, Peppa M, Goodman S, Ferrucci L, Striker G, Vlassara H. Circulating Fglycotoxins Fand Fdietary Fadvanced Fglycation Fendproducts: Ftwo Flinks Fto inflammatory response, oxidative stress, and aging. J Gerontol A Biol Sci Med Sci 2007; 62 (4): 427-433.
17. Goldberg T, Cai W, Peppa M, Dardaine V, Baliga BS, Uribarri J, Vlassara H. Advanced glycoxidation end products in commonly consumed foods. J Am Diet Assoc 2004; 104 (8): 1287-1291.
18. Xanthis A, Hatzitolios A, Koliakos G, Tatola V. Advanced gly-cosylation end products and nutrition-a possible relation with diabetic atherosclerosis and how to prevent it. J Food Sci 2007; 72 (8): R125-129.
19. Cai W, He JC, Zhu L, Chen X, Zheng F, Striker GE, Vlassara H. Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan. Am J Pathol 2008; 173 (2): 327-336.
20. Vlassara H, Cai W, Goodman S, Pyzik R, Yong A, Chen X, Zhu L, Neade T, Beeri M, Silverman JM, Ferrucci L, Tansman L, Striker GE, Uribarri J. Protection against loss of innate defenses in adulthood by low advanced glycation end products (AGE) intake: role of the antiinflammatory AGE receptor-1. J Clin Endocrinol Metab 2009; 94 (11): 4483-4491.
21. Uribarri J, Cai W, Ramdas M, Goodman S, Pyzik R, Chen X, Zhu L, Striker GE, Vlassara H. Restriction of advanced glyca-tion end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1. Diabetes Care 2011; 34 (7): 1610-1616.
22. Sandu O, Song K, Cai W, Zheng F, Uribarri J, Vlassara H. Insulin resistance and type 2 diabetes in high-fat-fed mice are linked to high glycotoxin intake. Diabetes 2005; 54 (8): 2314-2319.
23. Negrean M, Stirban A, Stratmann B, Gawlowski T, Horstmann T, Gotting C, Kleesiek K, Mueller-Roesel M, Koschinsky T, Uribarri J, Vlassara H, Tschoepe D. Effects of low- and high-advanced glycation endproduct meals on macro- and microvascular endothelial function and oxidative stress in patients with type 2 diabetes mellitus. Am J Clin Nutr 2007; 85 (5): 1236-1243.
24. Birlouez-Aragon I, Saavedra G, Tessier FJ, Galinier A, Ait-Ameur L, Lacoste F, Niamba CN, Alt N, Somoza V, Lecerf JM. A diet based on high-heat-treated foods promotes risk factors for diabetes mellitus and cardiovascular diseases. Am J Clin Nutr 2010; 91 (5): 1220-1226.
25. Stirban A, Negrean M, Gotting C, Uribarri J, Gawlowski T, Stratmann B, Kleesiek K, Koschinsky T, Vlassara H, Tschoepe D. Dietary advanced glycation endproducts and oxidative stress: in vivo effects on endothelial function and adipokines. Ann N Y Acad Sci 2008; 1126: 276-279.
26. Tikellis C, Thomas MC, Harcourt BE, Coughlan MT, Pete J, Bialkowski K, Tan A, Bierhaus A, Cooper ME, Forbes JM. Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs. Am J Physiol Endocrinol Metab 2008; 295 (2): E323-330.
27. Aso Y, Inukai T, Tayama K, Takemura Y. Serum concentrations of advanced glycation endproducts are associated with the development of atherosclerosis as well as diabetic microangiopathy in patients with type 2 diabetes. Acta Diabetol 2000; 37 (2): 87-92.
28. Hirata K, Kubo K. Relationship between blood levels of N-car-boxymethyl-lysine and pentosidine and the severity of micro-angiopathy in type 2 diabetes. Endocr J 2004. 51 (6): 537-544.
29. Wautier MP, Massin P, Guillausseau PJ, Huijberts M, Levy B, Boulanger E, Laloi-Michelin M, Wautier JL. N(carboxy-methyl)lysine as a biomarker for microvascular complications in type 2 diabetic patients. Diabetes Metab 2003; 29 (1): 44-52.
30. Gao X, Zhang H, Schmidt AM, Zhang C. AGE/RAGE produces endothelial dysfunction in coronary arterioles in type 2 diabetic mice. Am J Physiol Heart Circ Physiol 2008; 295 (2): H491-498.
31. Yamagishi S, Matsui T, Ueda S, Nakamura K, Imaizumi T. Advanced glycation end products (AGEs) and cardiovascular disease (CVD) in diabetes. Cardiovasc Hematol Agents Med Chem 2007; 5 (3): 236-240.
32. Barbosa J, Tojal e Seara L. O papel dos produtos finais da glica-cao avancada (AGEs) no desencadeamento das complicacoes vasculares do diabetes. Arq Bras Endocrinol Metab 2008; 52 (6): 940-950.
33. Sebekova K. Somoza V. Dietary advanced glycation endpro-ducts (AGEs) and their health effects-PRO. Mol Nutr Food Res 2007; 51 (9): 1079-1084.
34. Yamagishi S, Matsui T, Nakamura K. Possible link of food-derived advanced glycation end products (AGEs) to the development of diabetes. Med Hypotheses 2008; 71 (6): 876-878.
35. De la Maza M, Garrido F, Escalante N, Leiva L, Barrera G, Schnitzler S, Zanolli M, Verdaguer J, Hirsch S, Jara N, Bunout D. Cluorescent advanced glycation end-products (AGEs) detected by spectro-photofluorimetry, as a screening tool to detect diabetic microvascular complications. Journal of Diabetes Mellitus,2012; in press.
36. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16 (1): 31-41.
37. Matsuda M. Measuring and estimating insulin resistance in clinical and research settings. Nutr Metab Cardiovasc Dis 2010; 20 (2): 79-86.
38. Sabate J. Estimating food consumption: methods and challenges. Med Clin (Barc) 1993; 100 (15): 591-596.
39. Uribarri J, Cai W, Sandu O, Peppa M, Goldberg T, Vlassara H. Diet-derived advanced glycation end products are major contributors to the body's AGE pool and induce inflammation in healthy subjects. Ann N Y Acad Sci 2005; 1043: 461-466.
40. Cai W, He JC, Zhu L, Chen X, Wallenstein S, Striker GE, Vlas-sara H. Reduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expression. Am J Pathol 2007; 170 (6): 1893-1902.
41. Sebekova K, Somoza V, Jarcuskova M, Heidland A, Podracka L. Plasma advanced glycation end products are decreased in obese children compared with lean controls. Int J Pediatr Obes 2009; 4 (2): 112-118.
42. Semba RD, Arab L, Sun K, Nicklett EJ, Ferrucci L. Cat Mass Is Inversely Associated with Serum Carboxymethyl-Lysine, An Advanced Glycation End Product, in Adults. J Nutr 2011.
43. Al-Abed Y, Mitsuhashi T, Li H, Lawson JA, FitzGerald GA, Founds H, Donnelly T, Cerami A, Ulrich P, Bucala R. Inhibition of advanced glycation endproduct formation by acetal-dehyde: role in the cardioprotective effect of ethanol. Proc Natl Acad Sci USA 1999; 96 (5): 2385-2390.
44. Boehm BO, Schilling S, Rosinger S, Lang GE, Lang GK, Kientsch-Engel R, Stahl P. Elevated serum levels of N(epsi-lon)-carboxymethyl-lysine, an advanced glycation end product, are associated with proliferative diabetic retinopathy and macu-lar oedema. Diabetologia 2004; 47 (8): 1376-1379.
45. Schiel R, Franke S, Appel T, Voigt U, Ross IS, Kientsch-Engel R, Muller UA, Stein G. Improvement of the quality of diabetes control and decrease in the concentrations of AGE-products in patients with type 1 and insulin-treated type 2 diabetes mellitus: results from a 10 year-prospective, population-based survey on the quality of diabetes care in Germany (JEVIN). Eur J Med Res 2004; 9 (8): 391-399.
46. Chao PC, Huang CN, Hsu CC, Yin MC, Guo YR. Association of dietary AGEs with circulating AGEs, glycated LDL, IL-1alpha and MCP-1 levels in type 2 diabetic patients. Eur J Nutr 49 (7): 429-434.
47. Ahmed N, Mirshekar-Syahkal B, Kennish L, Karachalias N, Babaei-Jadidi R, Thornalley PJ. Assay of advanced glycation endproducts in selected beverages and food by liquid chroma-tography with tandem mass spectrometric detection. Mol Nutr Food Res 2005; 49 (7): 691-699.
48. Mericq V, Piccardo C, Cai W, Chen X, Zhu L, Striker GE, Vlas-sara H, Uribarri J. Maternally transmitted and food-derived gly-cotoxins: a factor preconditioning the young to diabetes? Diabetes Care 2010; 33 (10): 2232-2237.
49. Sebekova K, Saavedra G, Zumpe C, Somoza V, Klenovicsova K, Birlouez-Aragon I. Plasma concentration and urinary excretion of N epsilon-(carboxymethyl)lysine in breast milk- and formula-fed infants. Ann N Y Acad Sci 2008; 1126: 177-180.
50. Delgado-Andrade C, Seiquer I, Navarro MP, Morales FJ. Mai-llard reaction indicators in diets usually consumed by adolescent population. Mol Nutr Food Res 2007; 51 (3): 341-351.
51. Sun JK, Keenan HA, Cavallerano JD, Asztalos BF, Schaefer EJ, Sell DR, Strauch CM, Monnier VM, Doria A, Aiello LP, King GL. Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: the joslin 50-year medalist study. Diabetes Care 2011; 34 (4): 968-974.