메뉴 건너뛰기




Volumn 40, Issue 3, 2012, Pages 311-318

Genotypic resistance profiles associated with virological failure to darunavir-containing regimens: A cross-sectional analysis

Author keywords

Darunavir; Genotypic resistance; Protease inhibitors; Ritonavir boosted darunavir

Indexed keywords

DARUNAVIR; DARUNAVIR PLUS RITONAVIR; ISOLEUCINE; PROLINE; PROTEINASE; PROTEINASE INHIBITOR; THREONINE; VALINE;

EID: 84864286386     PISSN: 03008126     EISSN: 14390973     Source Type: Journal    
DOI: 10.1007/s15010-011-0237-y     Document Type: Article
Times cited : (19)

References (34)
  • 1
    • 19544386471 scopus 로고    scopus 로고
    • TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates
    • De Meyer S, Azijn H, Surleraux D, Jochmans D, Tahri A, Pauwels R, Wigerinck P, de Béthune MP. TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates. Antimicrob Agents Chemother. 2005; 49:2314-21.
    • (2005) Antimicrob Agents Chemother. , vol.49 , pp. 2314-2321
    • De Meyer, S.1    Azijn, H.2    Surleraux, D.3    Jochmans, D.4    Tahri, A.5    Pauwels, R.6    Wigerinck, P.7    De Béthune, M.P.8
  • 2
    • 55049134097 scopus 로고    scopus 로고
    • Resilience to resistance of HIV-1 protease inhibitors: Profile of darunavir
    • Lefebvre E, Schiffer CA. Resilience to resistance of HIV-1 protease inhibitors: profile of darunavir. AIDS Rev. 2008;10:131-42.
    • (2008) AIDS Rev. , vol.10 , pp. 131-142
    • Lefebvre, E.1    Schiffer, C.A.2
  • 3
    • 37049036372 scopus 로고    scopus 로고
    • Binding kinetics of darunavir to human immunodeficiency virus type 1 protease explain the potent antiviral activity and high genetic barrier
    • Dierynck I, De Wit M, Gustin E, Keuleers I, Vandersmissen J, Hallenberger S, Hertogs K. Binding kinetics of darunavir to human immunodeficiency virus type 1 protease explain the potent antiviral activity and high genetic barrier. J Virol. 2007;81: 13845-51.
    • (2007) J Virol. , vol.81 , pp. 13845-13851
    • Dierynck, I.1    De Wit, M.2    Gustin, E.3    Keuleers, I.4    Vandersmissen, J.5    Hallenberger, S.6    Hertogs, K.7
  • 5
    • 11144354478 scopus 로고    scopus 로고
    • High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains
    • Tie Y, Boross PI, Wang YF, Gaddis L, Hussain AK, Leshchenko S, Ghosh AK, Louis JM, Harrison RW, Weber IT. High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains. J Mol Biol. 2004;338:341-52.
    • (2004) J Mol Biol. , vol.338 , pp. 341-352
    • Tie, Y.1    Boross, P.I.2    Wang, Y.F.3    Gaddis, L.4    Hussain, A.K.5    Leshchenko, S.6    Ghosh, A.K.7    Louis, J.M.8    Harrison, R.W.9    Weber, I.T.10
  • 6
    • 5444247213 scopus 로고    scopus 로고
    • Combating susceptibility to drug resistance: Lessons from HIV-1 protease
    • King NM, Prabu-Jeyabalan M, Nalivaika EA, Schiffer CA. Combating susceptibility to drug resistance: lessons from HIV-1 protease. Chem Biol. 2004;11:1333-8.
    • (2004) Chem Biol. , vol.11 , pp. 1333-1338
    • King, N.M.1    Prabu-Jeyabalan, M.2    Nalivaika, E.A.3    Schiffer, C.A.4
  • 9
    • 64649102226 scopus 로고    scopus 로고
    • Darunavir: A review of its use in the management of HIV infection in adults
    • McKeage K, Perry CM, Keam SJ. Darunavir: a review of its use in the management of HIV infection in adults. Drugs. 2009;69: 477-503.
    • (2009) Drugs. , vol.69 , pp. 477-503
    • McKeage, K.1    Perry, C.M.2    Keam, S.J.3
  • 16
    • 55849125465 scopus 로고    scopus 로고
    • Darunavir inhibitory quotient predicts the 48-week virological response to darunavir-based salvage therapy in human immunodeficiency virus-infected protease inhibitor-experienced patients
    • Moltó J, Santos JR, Pérez-Alvarez N, Cedeño S, Miranda C, Khoo S, Else L, Llibre JM, Valle M, Clotet B. Darunavir inhibitory quotient predicts the 48-week virological response to darunavir-based salvage therapy in human immunodeficiency virus-infected protease inhibitor-experienced patients. Antimicrob Agents Chemother. 2008;52:3928-32.
    • (2008) Antimicrob Agents Chemother. , vol.52 , pp. 3928-3932
    • Moltó, J.1    Santos, J.R.2    Pérez-Alvarez, N.3    Cedeño, S.4    Miranda, C.5    Khoo, S.6    Else, L.7    Llibre, J.M.8    Valle, M.9    Clotet, B.10
  • 17
    • 34248549145 scopus 로고    scopus 로고
    • Key amprenavir resistance mutations counteract dramatic efficacy of darunavir in highly experienced patients
    • Delaugerre C, Mathez D, Peytavin G, Berthé H, Long K, Galperine T, de Truchis P. Key amprenavir resistance mutations counteract dramatic efficacy of darunavir in highly experienced patients. AIDS. 2007;21:1210-3.
    • (2007) AIDS , vol.21 , pp. 1210-1213
    • Delaugerre, C.1    Mathez, D.2    Peytavin, G.3    Berthé, H.4    Long, K.5    Galperine, T.6    De Truchis, P.7
  • 20
    • 84862146907 scopus 로고    scopus 로고
    • ARTEMIS: 192-week efficacy and safety of once-daily darunavir/ritonavir versus lopinavir/ritonavir in treatment-naïve HIV-1-infected adults
    • Proceedings of the 10th International Congress on Drug Therapy in HIV Infection, Glasgow, UK, 7-11 November 2010
    • Orkin C, DeJesus E, Khanlou H, Stoehr A, Supparatpinyo K, Van de Casteele T, Lathouwers E, Spinosa-Guzman S. ARTEMIS: 192-week efficacy and safety of once-daily darunavir/ritonavir versus lopinavir/ritonavir in treatment-naïve HIV-1-infected adults. In: Proceedings of the 10th International Congress on Drug Therapy in HIV Infection, Glasgow, UK, 7-11 November 2010. J Int AIDS Soc. 2010;13:P3.
    • (2010) J Int AIDS Soc. , vol.13
    • Orkin, C.1    Dejesus, E.2    Khanlou, H.3    Stoehr, A.4    Supparatpinyo, K.5    Van De Casteele, T.6    Lathouwers, E.7    Spinosa-Guzman, S.8
  • 24
    • 84864284517 scopus 로고    scopus 로고
    • Stanford University, HIV Drug Resistance Database
    • Stanford University, HIV Drug Resistance Database. http://hivdb. stanford.edu/.
  • 29
    • 70349189262 scopus 로고    scopus 로고
    • Phenotypic and genotypic determinants of resistance to darunavir: Analysis of data from treatment-experienced patients in POWER 1, 2,3 and DUET-1 and DUET-2
    • Proceedings of the XVIIth International HIV Drug Resistance Workshop, Sitges, Spain, 10-14 June 2008, (abs 31)
    • De Meyer S, Dierynck I, Lathouwers E, Van Baelen B, Vangeneugden T, Spinosa-Guzman S, Peeters M, Picchio G, de Béthune MP. Phenotypic and genotypic determinants of resistance to darunavir: analysis of data from treatment-experienced patients in POWER 1, 2, 3 and DUET-1 and DUET-2. In: Proceedings of the XVIIth International HIV Drug Resistance Workshop, Sitges, Spain, 10-14 June 2008. Antivir Ther 2008;13(Suppl 3):A33 (abs 31).
    • (2008) Antivir Ther , vol.13 , Issue.SUPPL. 3
    • De Meyer, S.1    Dierynck, I.2    Lathouwers, E.3    Van Baelen, B.4    Vangeneugden, T.5    Spinosa-Guzman, S.6    Peeters, M.7    Picchio, G.8    De Béthune, M.P.9
  • 32
    • 77952624269 scopus 로고    scopus 로고
    • Low rate of tipranavir and darunavir resistance mutations in PI-experienced patients using the new interpretation scores-implications for PI sequencing
    • Proceedings of the XVIIth International HIV Drug Resistance Workshop Sitges Spain, 10-14 June 2008, (abs 97)
    • Garrido C, Poveda E, Corral A, de Mendoza C, Soriano V. Low rate of tipranavir and darunavir resistance mutations in PI-experienced patients using the new interpretation scores-implications for PI sequencing. In: Proceedings of the XVIIth International HIV Drug Resistance Workshop, Sitges, Spain, 10-14 June 2008. Antivir Ther 2008;13(Suppl 3):A107 (abs 97).
    • (2008) Antivir Ther , vol.13 , Issue.SUPPL. 3
    • Garrido, C.1    Poveda, E.2    Corral, A.3    De Mendoza, C.4    Soriano, V.5
  • 34
    • 77952659138 scopus 로고    scopus 로고
    • Predicting tipranavir and darunavir resistance using genotypic, phenotypic, and virtual phenotypic resistance patterns: An independent cohort analysis of clinical isolates highly resistant to all other protease inhibitors
    • Talbot A, Grant P, Taylor J, Baril JG, Liu TF, Charest H, Brenner B, Roger M, Shafer R, Cantin R, Zolopa A. Predicting tipranavir and darunavir resistance using genotypic, phenotypic, and virtual phenotypic resistance patterns: an independent cohort analysis of clinical isolates highly resistant to all other protease inhibitors. Antimicrob Agents Chemother. 2010;54:2473-9.
    • (2010) Antimicrob Agents Chemother. , vol.54 , pp. 2473-2479
    • Talbot, A.1    Grant, P.2    Taylor, J.3    Baril, J.G.4    Liu, T.F.5    Charest, H.6    Brenner, B.7    Roger, M.8    Shafer, R.9    Cantin, R.10    Zolopa, A.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.