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Volumn 57, Issue 6, 2012, Pages 1604-1608

Infliximab exerts no direct hepatotoxic effect on HepG2 cells in vitro

Author keywords

6 mercaptopurine; 6 thioguanine; Azathioprine; Hepatotoxicity; HepG2 cells; Inflammatory bowel disease; Infliximab; Methotrexate

Indexed keywords

AZATHIOPRINE; INFLIXIMAB; MERCAPTOPURINE; METHOTREXATE; TIOGUANINE;

EID: 84864285492     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-012-2159-7     Document Type: Article
Times cited : (11)

References (27)
  • 2
    • 77749343043 scopus 로고    scopus 로고
    • Gastrointestinal and liver adverse effects of drugs used for treating IBD
    • Rogler G. Gastrointestinal and liver adverse effects of drugs used for treating IBD. Best Pract Res Clin Gastroenterol. 2010;24: 157-165.
    • (2010) Best Pract Res Clin Gastroenterol. , vol.24 , pp. 157-165
    • Rogler, G.1
  • 3
    • 77957882731 scopus 로고    scopus 로고
    • Hepatotoxicity of agents used in the management of inflammatory bowel disease
    • Khokhar OS, Lewis JH. Hepatotoxicity of agents used in the management of inflammatory bowel disease. Dig Dis. 2010;28: 508-518.
    • (2010) Dig Dis. , vol.28 , pp. 508-518
    • Khokhar, O.S.1    Lewis, J.H.2
  • 4
    • 84864284960 scopus 로고    scopus 로고
    • Accessed 5 April 2012
    • US Food and Drug Association (2004) MedWatch safety alerts for human medical products. http://www.fda.gov/medWatch/safety/2004/remicade-DHCP-dec04. pdf. Accessed 5 April 2012
    • (2004) MedWatch Safety Alerts for Human Medical Products
  • 5
    • 0345961813 scopus 로고    scopus 로고
    • Federal Drug Administration Accessed 5 April 2012
    • Federal Drug Administration (2009) REMICADE® (infliximab)for IV Injection. http://www.accessdata.fda.gov/drugsatfda-docs/label/2009/ 103772s5234lbl.pdf. Accessed 5 April 2012
    • (2009) REMICADE® (infliximab)for IV Injection
  • 6
    • 77956049370 scopus 로고    scopus 로고
    • Risk of elevated liver enzymes associated with TNF inhibitor utilisation in patients with rheumatoid arthritis
    • Sokolove J, Strand V, Greenberg JD, et al. Risk of elevated liver enzymes associated with TNF inhibitor utilisation in patients with rheumatoid arthritis. Ann Rheum Dis. 2010;69:1612-1617.
    • (2010) Ann Rheum Dis. , vol.69 , pp. 1612-1617
    • Sokolove, J.1    Strand, V.2    Greenberg, J.D.3    Et Al.4
  • 7
    • 77953542643 scopus 로고    scopus 로고
    • Infliximab-related hepatitis: Discussion of a case and review of the literature
    • Mancini S, Amorotti E, Vecchio S, et al. Infliximab-related hepatitis: discussion of a case and review of the literature. Intern Emerg Med. 2010;5:193-200.
    • (2010) Intern Emerg Med. , vol.5 , pp. 193-200
    • Mancini, S.1    Amorotti, E.2    Vecchio, S.3    Et Al.4
  • 9
    • 77956928883 scopus 로고    scopus 로고
    • Hepatotoxicity assay using human hepatocytes trapped in microholes of a microfluidic device
    • Yeon JH, Na D, Park JK. Hepatotoxicity assay using human hepatocytes trapped in microholes of a microfluidic device. Electrophoresis. 2010;31:3167-3174.
    • (2010) Electrophoresis. , vol.31 , pp. 3167-3174
    • Yeon, J.H.1    Na, D.2    Park, J.K.3
  • 10
    • 38549176118 scopus 로고    scopus 로고
    • Tumor necrosis factor antagonist mechanisms of action: A comprehensive review
    • Tracey D, Klareskog L, Sasso EH, et al. Tumor necrosis factor antagonist mechanisms of action: a comprehensive review. Pharmacol Ther. 2008;117:244-279.
    • (2008) Pharmacol Ther. , vol.117 , pp. 244-279
    • Tracey, D.1    Klareskog, L.2    Sasso, E.H.3    Et Al.4
  • 11
    • 0034014744 scopus 로고    scopus 로고
    • IgG immune complex binding to and activation of liver cells. An in vitro study with IgG immune complexes, Kupffer cells, sinusoidal endothelial cells and hepatocytes
    • Johansson AG, Sundqvist T, Skogh T. IgG immune complex binding to and activation of liver cells. An in vitro study with IgG immune complexes, Kupffer cells, sinusoidal endothelial cells and hepatocytes. Int Arch Allergy Immunol. 2000;121:329-336. (Pubitemid 30229646)
    • (2000) International Archives of Allergy and Immunology , vol.121 , Issue.4 , pp. 329-336
    • Johansson, A.G.1    Sundqvist, T.2    Skogh, T.3
  • 12
    • 79952446700 scopus 로고    scopus 로고
    • Hepatotoxicity related to antirheumatic drugs
    • Aithal GP. Hepatotoxicity related to antirheumatic drugs. Nat Rev Rheumatol. 2011;7:139-150.
    • (2011) Nat Rev Rheumatol. , vol.7 , pp. 139-150
    • Aithal, G.P.1
  • 14
    • 16344383360 scopus 로고    scopus 로고
    • Infliximab therapy in rheumatoid arthritis and ankylosing spondylitis-induced specific antinuclear and antiphospholipid autoantibodies without autoimmune clinical manifestations: A two-year prospective study
    • Ferraro-Peyret C, Coury F, Tebib JG, et al. Infliximab therapy in rheumatoid arthritis and ankylosing spondylitis-induced specific antinuclear and antiphospholipid autoantibodies without autoimmune clinical manifestations: a two-year prospective study. Arthritis Res Ther. 2004;6:R535-R543.
    • (2004) Arthritis Res Ther. , vol.6
    • Ferraro-Peyret, C.1    Coury, F.2    Tebib, J.G.3    Et Al.4
  • 16
    • 0026801421 scopus 로고
    • Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy
    • Akerman P, Cote P, Yang SO, et al. Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. Am J Physiol. 1992;263:G579-G585.
    • (1992) Am J Physiol. , vol.263
    • Akerman, P.1    Cote, P.2    Yang, S.O.3    Et Al.4
  • 17
    • 0031030599 scopus 로고    scopus 로고
    • Induction of early-immediate genes by tumor necrosis factor α contribute to liver repair following chemical-induced hepatotoxicity
    • Bruccoleri A, Gallucci R, Germolec DR, et al. Induction of early-immediate genes by tumor necrosis factor alpha contribute to liver repair following chemical-induced hepatotoxicity. Hepatology. 1997;25:133-141. (Pubitemid 27014999)
    • (1997) Hepatology , vol.25 , Issue.1 , pp. 133-141
    • Bruccoleri, A.1    Gallucci, R.2    Germolec, D.R.3    Blackshear, P.4    Simeonova, P.5    Thurman, R.G.6    Luster, M.I.7
  • 18
    • 78049506154 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor a treatment promotes apoptosis and prevents liver regeneration in a transgenic mouse model of chronic hepatitis C
    • Brenndörfer ED, Weiland M, Frelin L, et al. Anti-tumor necrosis factor a treatment promotes apoptosis and prevents liver regeneration in a transgenic mouse model of chronic hepatitis C. Hepatology. 2010;52:1553-1563.
    • (2010) Hepatology , vol.52 , pp. 1553-1563
    • Brenndörfer, E.D.1    Weiland, M.2    Frelin, L.3    Et Al.4
  • 19
    • 40049104027 scopus 로고    scopus 로고
    • Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes
    • Petit E, Langouet S, Akhdar H, et al. Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes. Toxicol In Vitro. 2008;22:632-642.
    • (2008) Toxicol in Vitro. , vol.22 , pp. 632-642
    • Petit, E.1    Langouet, S.2    Akhdar, H.3    Et Al.4
  • 20
    • 67349127924 scopus 로고    scopus 로고
    • Differential methotrexate hepatotoxicity on rat hepatocytes in 2-D monolayer culture and 3-D gel entrapment culture
    • Yin J, Meng Q, Zhang G, et al. Differential methotrexate hepatotoxicity on rat hepatocytes in 2-D monolayer culture and 3-D gel entrapment culture. Chem Biol Interact. 2009;180:368-375.
    • (2009) Chem Biol Interact. , vol.180 , pp. 368-375
    • Yin, J.1    Meng, Q.2    Zhang, G.3    Et Al.4
  • 22
    • 43549123035 scopus 로고    scopus 로고
    • Isoniazid and its toxic metabolite hydrazine induce in vitro pyrazinamide toxicity
    • Tostmann A, Boeree MJ, Peters WHM, et al. Isoniazid and its toxic metabolite hydrazine induce in vitro pyrazinamide toxicity. Int J Antimicrob Agents. 2008;31:577-580.
    • (2008) Int J Antimicrob Agents. , vol.31 , pp. 577-580
    • Tostmann, A.1    Boeree, M.J.2    Peters, W.H.M.3    Et Al.4
  • 23
    • 0020534019 scopus 로고
    • Variable bioavailability of oral mercaptopurine. Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered?
    • Zimm S, Collins JM, Riccardi R, et al. Variable bioavailability of oral mercaptopurine: is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered? N Engl J Med. 1983;308:1005-1009. (Pubitemid 13118706)
    • (1983) New England Journal of Medicine , vol.308 , Issue.17 , pp. 1005-1009
    • Zimm, S.1    Collins, J.M.2    Riccardi, R.3
  • 24
    • 0018635095 scopus 로고
    • Comparative bioavailability and pharmacokinetic studies of azathioprine and 6-mercaptopurine in the rhesus monkey
    • Ding TL, Benet LZ. Comparative bioavailability and pharmaco-kinetic study of azathioprine and 6-mercaptopurine in the rhesus monkey. Drug Metab Dispos. 1979;7:373-377. (Pubitemid 10176111)
    • (1979) Drug Metabolism and Disposition , vol.7 , Issue.6 , pp. 373-377
    • Ding, T.L.1    Benet, L.Z.2
  • 26
    • 0023491159 scopus 로고
    • The therapeutic use of azathioprine in renal transplantation
    • Chan GL, Canafax DM, Johnson CA. The therapeutic use of azathioprine in renal transplantation. Pharmacotherapy. 1987;7: 165-177. (Pubitemid 18001594)
    • (1987) Pharmacotherapy , vol.7 , Issue.5 , pp. 165-177
    • Chan, G.L.C.1    Canafax, D.M.2    Johnson, C.A.3
  • 27
    • 0042065286 scopus 로고    scopus 로고
    • Influence of culture time on the expression of drug-metabolizing enzymes in primary human hepatocytes and hepatoma cell line HepG2
    • DOI 10.1002/jbt.10085
    • Wilkening S, Bader A. Influence of culture time on the expression of drug-metabolizing enzymes in primary human hepato-cytes and hepatoma cell line HepG2. J Biochem Mol Toxicol. 2003;17:207-213. (Pubitemid 36974720)
    • (2003) Journal of Biochemical and Molecular Toxicology , vol.17 , Issue.4 , pp. 207-213
    • Wilkening, S.1    Bader, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.